gene

WNT3A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WNT3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

103Connections

0Hypotheses

1Analyses

50Outgoing

49Incoming

0Experiments

2Debates

Summary

WNT3A is a gene implicated in neurodegeneration research. Key relationships include: inhibits, activates, expressed in. Associated with ALS, Als, Alzheimer. Connected to 26 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	WNT3A
Chromosome	17q21.31
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	36 kDa
Amino Acids	352 aa
Exons	4
Pathways	Wnt, WNT
NCBI Gene ID	89780
Ensembl ID	ENSG00000134245
GeneCards	WNT3A
Human Protein Atlas	WNT3A
Associated Diseases	neurodegeneration
Interactions	Actin, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, BETA-CATENIN
KG Connections	103 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

WNT3A Gene

gene · 806 words

→

WNT3A Protein

protein · 598 words

→

Pathway Diagram

graph TD
    WNT3A["WNT3A"]
    Cancer{"Cancer"}
    WNT3A -->|"activates"| Cancer
    Inflammation{"Inflammation"}
    WNT3A -->|"expressed in"| Inflammation
    ALS{"ALS"}
    WNT3A -->|"inhibits"| ALS
    Alzheimer{"Alzheimer"}
    WNT3A -->|"inhibits"| Alzheimer
    WNT3A -->|"inhibits"| Cancer
    P38["P38"]
    WNT3A -->|"activates"| P38
    Wnt(["Wnt"])
    WNT3A -->|"activates"| Wnt
    Mapk(["Mapk"])
    WNT3A -->|"activates"| Mapk
    INFLAMMATION["INFLAMMATION"]
    WNT3A -->|"expressed in"| INFLAMMATION
    Epigenetic(["Epigenetic"])
    WNT3A -->|"inhibits"| Epigenetic
    WNT3A -->|"inhibits"| Wnt
    CANCER["CANCER"]
    WNT3A -->|"inhibits"| CANCER
    KLF14["KLF14"]
    KLF14 -->|"inhibits"| WNT3A
    CANCER -->|"activates"| WNT3A
    LRP6["LRP6"]
    LRP6 -->|"inhibits"| WNT3A
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"inhibits"| WNT3A
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"inhibits"| WNT3A
    CANCER -->|"inhibits"| WNT3A
    AND["AND"]
    AND -->|"inhibits"| WNT3A
    HDAC["HDAC"]
    HDAC -->|"inhibits"| WNT3A
    style WNT3A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (54)

Target	Relation	Type	Str
CTNNB1_signaling	activates	pathway	0.70
WNT PATHWAY	activates	pathway	0.70
Wnt	inhibits	pathway	0.70
Nephropathy	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Als	activates	disease	0.65
Fibrosis	inhibits	disease	0.65
Als	inhibits	disease	0.65
Cancer	activates	disease	0.65
AMYLOID	inhibits	protein	0.65
NEUROGENESIS	activates	phenotype	0.65
Als	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Inflammation	expressed_in	disease	0.65
INFLAMMATION	expressed_in	gene	0.60
WNT	inhibits	gene	0.60
Epigenetic	therapeutic_target	pathway	0.60
CACNA1G	activates	gene	0.60
Wnt	activates	pathway	0.60
Mapk	activates	pathway	0.60
Ras	activates	protein	0.60
P38	activates	gene	0.60
AND	inhibits	gene	0.60
LRP6	inhibits	gene	0.60
LRP6	therapeutic_target	gene	0.60
RANK	activates	gene	0.60
Osteoclast	activates	cell_type	0.60
thalamus	expressed_in	brain_region	0.60
CANCER	inhibits	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
stem cells	expressed_in	cell_type	0.60
AND	activates	gene	0.60
Actin	activates	protein	0.60
Epigenetic	inhibits	pathway	0.60
WNT	activates	gene	0.60
Wnt	regulates	pathway	0.60
Macrophage	activates	cell_type	0.60
WNT5A	expressed_in	gene	0.60
ATP6AP2	regulates	gene	0.60
DKK-1	activates	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
Neuron	activates	cell_type	0.60
Wnt signaling	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
Thalamus	expressed_in	brain_region	0.55
Hippocampus	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55

Incoming (49)

Source	Relation	Type	Str
h-eef1be45	targets	hypothesis	0.90
KLF14	inhibits	gene	0.80
STROKE	regulates	disease	0.65
NEURONS	inhibits	cell_type	0.65
STROKE	activates	disease	0.65
NEURONS	treats	cell_type	0.65
DEPRESSION	regulates	disease	0.65
WNT SIGNALING	activates	pathway	0.65
DEPRESSION	activates	disease	0.65
GFAP	regulates	gene	0.65
GENES	activates	gene	0.60
TGFB1	activates	gene	0.60
TAC1	activates	gene	0.60
TRPM8	activates	gene	0.60
CTNNB1	activates	gene	0.60
EGFR	activates	gene	0.60
MYC	activates	gene	0.60
CAV3	activates	gene	0.60
LEF1	activates	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
CANCER	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
PDGF	activates	gene	0.60
RHOA	inhibits	gene	0.60
ROCK1	inhibits	gene	0.60
RANKL	activates	gene	0.60
LRP6	inhibits	gene	0.60
CACNA1G	activates	gene	0.60
CANCER	inhibits	gene	0.60
HDAC	inhibits	gene	0.60
WNT	inhibits	gene	0.60
WNT	regulates	gene	0.60
DKK1	activates	gene	0.60
CANCER	activates	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
WNT PATHWAY	associated_with	pathway	0.50
LEF1	co_expressed_with	gene	0.50
NEURON	co_discussed	gene	0.50
CANCER	co_discussed	gene	0.50
ALZHEIMER	co_discussed	gene	0.50
LRP6	co_discussed	gene	0.50
WNT SIGNALING	associated_with	pathway	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
THALAMUS	associated_with	brain_region	0.45
STRIATUM	associated_with	brain_region	0.45
NEUROGENESIS	associated_with	phenotype	0.45
CACNA1G	co_mentioned	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

neurodegeneration | 2026-04-16 | 14 hypotheses Top: 0.806

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Should PEA-PPARA endocannabinoid signaling be prioritized as a therapeutic strat

closed · Rounds: 4 · Score: 0.76 · 2026-04-23

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

closed · Rounds: 7 · Score: 0.87 · 2026-04-16

Related Research

Hypotheses and analyses mentioning WNT3A in their description or question text

No additional research found