gene

SOCS3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SOCS3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

216Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Page for SOCS3 - Suppressor of Cytokine Signaling 3

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🧬 Gene Info

Gene Symbol	SOCS3
Full Name	Suppressor of Cytokine Signaling 3
Aliases	Page for SOCS3
Chromosome	17q25.3
Function	encodes a key negative feedback regulator of the JAK-STAT signaling pathway, one of the primary intracellular signaling cascades mediating cytokine and growth factor responses.
Amino Acids	225 aa
Pathways	JAK-STAT signaling, jak-stat, NF-κB
Ensembl ID	ENSG00000184557
GeneCards	SOCS3
Human Protein Atlas	SOCS3
IL-10	Limits anti-inflammatory IL-10 signaling duration
Leptin receptor	Contributes to leptin resistance
G-CSF/EPO receptors	Regulates hematopoietic cytokine signaling
Aβ-driven inflammation	Amyloid-beta oligomers activate JAK-STAT3 signaling in microglia and astrocytes. Inadequate SOCS3 feedback allows sustained IL-6, TNF-α, and complement production
Associated Diseases	neurodegeneration
Interactions	STAT3, CD4, JAK2, CCL20, CCR6, IL6
KG Connections	216 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SOCS3["<b>SOCS3</b>"]
    Inflammation{"Inflammation"}
    SOCS3 -->|"activates"| Inflammation
    Aging{"Aging"}
    SOCS3 -->|"activates"| Aging
    Ms{"Ms"}
    SOCS3 -->|"activates"| Ms
    Alzheimer{"Alzheimer"}
    SOCS3 -->|"therapeutic target"| Alzheimer
    Als{"Als"}
    SOCS3 -->|"therapeutic target"| Als
    SOCS3 -->|"therapeutic target"| Inflammation
    SOCS3 -->|"therapeutic target"| Ms
    SOCS3 -->|"regulates"| Aging
    SOCS3 -->|"regulates"| Ms
    TRPA1["TRPA1"]
    SOCS3 -->|"regulates"| TRPA1
    GENES["GENES"]
    SOCS3 -->|"regulates"| GENES
    CXCL2["CXCL2"]
    SOCS3 -->|"regulates"| CXCL2
    KLF14["KLF14"]
    KLF14 -->|"activates"| SOCS3
    PANX1["PANX1"]
    PANX1 -->|"regulates"| SOCS3
    S100B["S100B"]
    S100B -->|"regulates"| SOCS3
    RELB["RELB"]
    RELB -->|"regulates"| SOCS3
    P2RY1["P2RY1"]
    P2RY1 -->|"regulates"| SOCS3
    CASP3["CASP3"]
    CASP3 -->|"regulates"| SOCS3
    ICAM1["ICAM1"]
    ICAM1 -->|"associated with"| SOCS3
    CXCL1["CXCL1"]
    CXCL1 -->|"associated with"| SOCS3
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"therapeutic target"| SOCS3
    AGING["AGING"]
    AGING -->|"regulates"| SOCS3
    style SOCS3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (137)

Target	Relation	Type	Str
IL6	inhibits	protein	0.85
Inflammation	activates	disease	0.75
STAT3	regulates	gene	0.70
STAT3	activates	gene	0.70
TNF	activates	gene	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Aging	regulates	disease	0.65
Ms	regulates	disease	0.65
Colorectal Cancer	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Autoimmune	activates	disease	0.65
Rheumatoid Arthritis	activates	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Lung Cancer	activates	disease	0.65
Sepsis	therapeutic_target	disease	0.65
Alzheimer	regulates	disease	0.65
JAK-STAT signaling	participates_in	pathway	0.65
NF-kB signaling	participates_in	pathway	0.65
TRPA1	regulates	gene	0.60
CXCL2	regulates	gene	0.60
SNAP25	regulates	gene	0.60
P2RX7	regulates	gene	0.60
SYT2	regulates	gene	0.60
TNF	regulates	gene	0.60
SOD2	regulates	gene	0.60
NOS2	regulates	gene	0.60
P2RX3	regulates	gene	0.60
RELA	regulates	gene	0.60
SYP	regulates	gene	0.60
CHRNA7	regulates	gene	0.60
SYT1	regulates	gene	0.60
HMOX1	regulates	gene	0.60
TRPV1	regulates	gene	0.60
P2RY2	regulates	gene	0.60
FOXP3	regulates	gene	0.60
TPH2	regulates	gene	0.60
CCL3	regulates	gene	0.60
IL6	associated_with	gene	0.60
C5AR1	associated_with	gene	0.60
TNF	therapeutic_target	gene	0.60
HSPA1A	associated_with	gene	0.60
SERPINA3	therapeutic_target	gene	0.60
CD163	associated_with	gene	0.60
KCNB1	regulates	gene	0.60

Incoming (79)

Source	Relation	Type	Str
KLF14	activates	gene	0.80
IL30	upregulates	gene	0.80
IL6	upregulates	protein	0.70
IL-6	activates	gene	0.65
PANX1	regulates	gene	0.60
S100B	regulates	gene	0.60
RELB	regulates	gene	0.60
P2RY1	regulates	gene	0.60
CASP3	regulates	gene	0.60
ICAM1	associated_with	gene	0.60
CXCL1	associated_with	gene	0.60
MCL1	expressed_in	gene	0.60
C5AR1	associated_with	gene	0.60
SERPINA3	therapeutic_target	gene	0.60
IL6	associated_with	gene	0.60
TNF	therapeutic_target	gene	0.60
STAT3	activates	gene	0.60
TXNIP	activates	gene	0.60
AXIN1	activates	gene	0.60
RHEB	activates	gene	0.60
EGR1	activates	gene	0.60
HNF4A	activates	gene	0.60
MYC	activates	gene	0.60
YWHAZ	activates	gene	0.60
AXIN1	encodes	gene	0.60
HNF4A	encodes	gene	0.60
RHEB	encodes	gene	0.60
S100A8	expressed_in	gene	0.60
S100A9	expressed_in	gene	0.60
TFAM	activates	gene	0.60
OSMR	expressed_in	gene	0.60
DRP1	activates	gene	0.60
CASP4	expressed_in	gene	0.60
MYO1C	activates	gene	0.60
MYO1C	regulates	gene	0.60
IFNI	activates	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
AGING	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
PCK1	therapeutic_target	gene	0.60
GENES	associated_with	gene	0.60
HSPB1	associated_with	gene	0.60
AND	activates	gene	0.60
MYH9	activates	gene	0.60
HUB GENES	regulates	gene	0.60
AMYLOID	regulates	gene	0.60
MIRNAS	activates	gene	0.60
MICRORNAS	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SOCS3

Understanding Entity Pages

Summary

Wiki Pages (21)

SOCS3 - Suppressor of Cytokine Signaling 3

vitamin-d-therapy-neurodegeneration

JAK-STAT Signaling Pathway in Neurodegeneration

CNTFR Gene

Arcuate Nucleus POMC Neurons

IL3 (Interleukin 3)

IL-10 Protein

JAK-STAT and Cytokine Signaling in 4R-Tauopathies

IL25 (Interleukin 25)

IL31 (Interleukin 31)

IL9 (Interleukin 9)

STAT6 — Signal Transducer and Activator of Transcription 6

IL-12 Protein

STAT4 Gene

JAK-STAT Signaling in Parkinson's Disease

IL11 Gene

SOCS4 — Suppressor of Cytokine Signaling 4

CNTF Gene

JAK2 Gene - Janus Kinase 2