gene

KMT2C

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KMT2C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

4Outgoing

6Incoming

Summary

KMT2C is a gene implicated in neurodegeneration research. Key relationships include: expressed in, regulates, implicated in. Associated with Als, Cancer, Tumor. Connected to 10 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	KMT2C
Full Name	Lysine Methyltransferase 2C
Protein Type	Transferase
Function	KMT2C (also known as MLL3) is a histone H3K4 monomethyltransferase that plays a critical role in transcriptional activation through chromatin remodeling.
Primary Expression	all regions - Cerebellum: Present in granule cells - Allen Brain Atlas: [KMT2C expression data](https://human
Amino Acids	900 aa
Ensembl ID	ENSG00000055607
GeneCards	KMT2C
Human Protein Atlas	KMT2C
H3K4 Methylation	Catalyzes H3K4me1, a mark associated with enhancer activation
Transcriptional Coactivation	Works with the COMPASS complex
Metabolic Regulation	Involved in adipogenesis and lipid metabolism
SET Domain	Catalytic methyltransferase domain
PHD Fingers	Zinc fingers for chromatin reader function
FYR Domain	Fungal yeast R-related domains
Associated Diseases	neurodegeneration
KG Connections	10 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    KMT2C["<b>KMT2C</b>"]
    Als{"Als"}
    KMT2C -->|"regulates"| Als
    Cancer{"Cancer"}
    KMT2C -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    KMT2C -->|"expressed in"| Tumor
    Epigenetic(["Epigenetic"])
    KMT2C -->|"expressed in"| Epigenetic
    neurodegeneration["neurodegeneration"]
    KMT2C -->|"implicated in"| neurodegeneration
    KMT2D["KMT2D"]
    KMT2D -->|"expressed in"| KMT2C
    STK11["STK11"]
    STK11 -->|"expressed in"| KMT2C
    CANCER["CANCER"]
    CANCER -->|"expressed in"| KMT2C
    PTEN["PTEN"]
    PTEN -->|"expressed in"| KMT2C
    RB1["RB1"]
    RB1 -->|"expressed in"| KMT2C
    style KMT2C fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (4)

Target	Relation	Type	Str
Als	regulates	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Epigenetic	expressed_in	pathway	0.60

Incoming (6)

Source	Relation	Type	Str
KMT2D	expressed_in	gene	0.60
STK11	expressed_in	gene	0.60
PTEN	expressed_in	gene	0.60
RB1	expressed_in	gene	0.60
FOXP2	associated_with	gene	0.60
CANCER	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found