gene

STK11

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STK11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

300Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

STK11 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, associated with. Associated with Als, Alzheimer, Ataxia. Connected to 158 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	STK11
Full Name	Serine/Threonine Kinase 11
Aliases	Page for STK11, Page for STK11 Protein
Chromosome	19p13.3
Protein Type	Protein
Function	is a serine/threonine kinase that functions as a master regulator of cellular energy metabolism and stress responses.
Primary Expression	mammalian tissues with particularly high levels in the brain, liver, and skeletal muscle
Molecular Weight	48.6 kDa
Amino Acids	433 aa
Exons	9
Pathways	AMPK, AMPK pathway, AMPK Pathway
UniProt ID	Search UniProt
GeneCards	STK11
Human Protein Atlas	STK11
Associated Diseases	ALS, Alzheimer, Cancer, Parkinson, multiple sclerosis
Known Drugs/Compounds	Crocetin, rapamycin
Interactions	MAPT, PTEN, RB1, ULK1, TAU, MTOR
KG Connections	300 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: STK11 — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    STK11["STK11"]
    STK11 -->|"activates"| Alzheimer["Alzheimer"]
    STK11 -->|"contributes to"| Cancer["Cancer"]
    STK11 -->|"contributes to"| Ms["Ms"]
    STK11 -->|"expressed in"| Als["Als"]
    STK11 -->|"inhibits"| Tumor["Tumor"]
    STK11 -->|"regulates"| Ataxia["Ataxia"]
    STK11 -->|"activates"| Carcinoma["Carcinoma"]
    ACTB["ACTB"] -->|"regulates"| STK11
    CDC42["CDC42"] -->|"regulates"| STK11
    CASP3["CASP3"] -->|"regulates"| STK11
    MAPT["MAPT"] -->|"activates"| STK11
    IDH1["IDH1"] -->|"contributes to"| STK11
    VHL["VHL"] -->|"contributes to"| STK11
    MTOR["MTOR"] -->|"contributes to"| STK11
    PTEN["PTEN"] -->|"contributes to"| STK11
    AMPK["AMPK"] -->|"activates"| STK11
    AKT["AKT"] -->|"contributes to"| STK11

Outgoing (171)

Target	Relation	Type	Str
MTOR Pathway Activity	inhibits	process	0.85
MTOR	inhibits	protein	0.85
PI3K/AKT/mTOR	regulates	pathway	0.85
Copy Number Loss	associated_with	mechanism	0.80
Alzheimer	activates	disease	0.65
Cancer	contributes_to	disease	0.65
Ms	contributes_to	disease	0.65
Als	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	inhibits	disease	0.65
Cancer	regulates	disease	0.65
Ataxia	regulates	disease	0.65
Cancer	activates	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	implicated_in	disease	0.65
Tumor	activates	disease	0.65
Als	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Carcinoma	expressed_in	disease	0.65
Cancer	associated_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	inhibits	disease	0.65
Multiple Sclerosis	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
ALS	inhibits	disease	0.65
PI3K_AKT_MTOR_pathway	regulates	pathway	0.64
VIM	associated_with	gene	0.60
BECN1	regulates	gene	0.60
HDAC6	associated_with	gene	0.60
GAPDH	regulates	gene	0.60
MAP1LC3B	associated_with	gene	0.60
MAP3K5	associated_with	gene	0.60
UVRAG	associated_with	gene	0.60
H2AX	regulates	gene	0.60
OCLN	associated_with	gene	0.60
RAC1	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
ATG14	regulates	gene	0.60
GJA1	regulates	gene	0.60
LAMP1	associated_with	gene	0.60
CDC42	regulates	gene	0.60
SQSTM1	associated_with	gene	0.60
CASP3	regulates	gene	0.60
P62	associated_with	gene	0.60
ACTB	regulates	gene	0.60
TUBB3	associated_with	gene	0.60
MAPT	activates	gene	0.60
PTEN	contributes_to	gene	0.60
PI3K	contributes_to	gene	0.60

Incoming (129)

Source	Relation	Type	Str
Crocetin	activates	compound	0.85
AMPK	activates	gene	0.70
ACTB	regulates	gene	0.60
CDC42	regulates	gene	0.60
CASP3	regulates	gene	0.60
SQSTM1	associated_with	gene	0.60
TUBB3	associated_with	gene	0.60
MAPT	activates	gene	0.60
IDH1	contributes_to	gene	0.60
VHL	contributes_to	gene	0.60
MTOR	contributes_to	gene	0.60
PTEN	contributes_to	gene	0.60
AKT	contributes_to	gene	0.60
PI3K	contributes_to	gene	0.60
KMT2D	expressed_in	gene	0.60
ATM	regulates	gene	0.60
TP53	regulates	gene	0.60
NBN	regulates	gene	0.60
BRIP1	regulates	gene	0.60
PRKDC	activates	gene	0.60
TUBULIN	associated_with	gene	0.60
P62	associated_with	gene	0.60
MAP3K5	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
OCLN	associated_with	gene	0.60
GJA1	regulates	gene	0.60
GAPDH	regulates	gene	0.60
UVRAG	associated_with	gene	0.60
RAC1	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
VIM	associated_with	gene	0.60
H2AX	regulates	gene	0.60
PIK3C3	associated_with	gene	0.60
TAU	activates	gene	0.60
IDH1	implicated_in	gene	0.60
VHL	implicated_in	gene	0.60
PI3K	implicated_in	gene	0.60
AKT	implicated_in	gene	0.60
TFEB	activates	gene	0.60
MAP3K7	activates	gene	0.60
PP2A	activates	gene	0.60
KEAP1	activates	gene	0.60
SQSTM1	activates	gene	0.60
TAK1	activates	gene	0.60
NRF2	activates	gene	0.60
NFE2L2	activates	gene	0.60
TFE3	activates	gene	0.60
P62	activates	gene	0.60
KEAP1	therapeutic_target	gene	0.60
CDKN2A	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

STK11

Understanding Entity Pages

Summary

Wiki Pages (21)

STK11 - Serine/Threonine Kinase 11

Centrosome

pard3

PRKAA2 (AMPKα2) — AMP-Activated Protein Kinase Catalytic Subunit Alpha 2

AMPK Activators for Neurodegeneration

MARK Tau Phosphorylation Pathway - Microtubule Affinity Regulating Kinase

PRKAB1 — Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1

MST4 Gene

AMPK Signaling in Parkinson's Disease

cdkn2a

AMPK Protein

AMPK Activator Therapies

MARK4 Protein (Microtubule Affinity Regulating Kinase 4)

BRSK1 Gene

KMT2C — Lysine Methyltransferase 2C

STK11 Protein - LKB1 - Serine/Threonine Kinase 11

PRKAA1

lkb1-protein

AMPK-Mitochondrial Quality Control Axis