gene

FOXP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FOXP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

117Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

FOXP2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, expressed in, activates. Associated with Als, Alzheimer, Autism. Connected to 84 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	FOXP2
Full Name	Forkhead Box P2
Chromosome	7q31.1
Protein Type	Transcription Factor
Function	encodes a transcription factor critically involved in neuronal development, synaptic plasticity, and speech/language acquisition.
Primary Expression	basal ganglia, cortex, and cerebellum
Molecular Weight	80 kDa
Amino Acids	715 aa
Exons	17
Pathways	MAPK
UniProt ID	O15409
NCBI Gene ID	2301
Ensembl ID	ENSG00000128573
OMIM	605317
GeneCards	FOXP2
Human Protein Atlas	FOXP2
Associated Diseases	Addiction, Als, Alzheimer, Autoimmune, Cancer, Carcinoma
Interactions	DISC1
KG Connections	117 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FOXP2 — AlphaFold O15409 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

FOXP2 Gene

gene · 861 words

→

FOXP2 Protein

protein · 1253 words

→

Pathway Diagram

graph TD
    FOXP2["FOXP2"]
    FOXP2 -->|"upregulates"| MHC_I["MHC-I"]
    FOXP2 -->|"expressed in"| Diabetes["Diabetes"]
    FOXP2 -->|"expressed in"| Cancer["Cancer"]
    FOXP2 -->|"expressed in"| Carcinoma["Carcinoma"]
    FOXP2 -->|"activates"| Schizophrenia["Schizophrenia"]
    FOXP2 -->|"activates"| Autism["Autism"]
    FOXP2 -->|"activates"| Als["Als"]
    FOXP2 -->|"activates"| Depression["Depression"]
    FOXP2 -->|"activates"| Bipolar["Bipolar"]
    FOXP2 -->|"expressed in"| Epigenetic["Epigenetic"]
    CNTN6["CNTN6"] -->|"regulates"| FOXP2
    SHH["SHH"] -->|"expressed in"| FOXP2
    CANCER["CANCER"] -->|"expressed in"| FOXP2
    DIABETES_MELLITUS["DIABETES MELLITUS"] -->|"expressed in"| FOXP2
    DISC1["DISC1"] -->|"activates"| FOXP2

Outgoing (65)

Target	Relation	Type	Str
TREM2	associated_with	gene	0.80
MHC-I	upregulates	protein	0.70
Glioblastoma	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Obesity	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Fibrosis	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Leukemia	associated_with	disease	0.65
Autoimmune	associated_with	disease	0.65
Als	associated_with	disease	0.65
Hepatitis	associated_with	disease	0.65
Als	activates	disease	0.65
Depression	activates	disease	0.65
Bipolar	activates	disease	0.65
Opioid	associated_with	disease	0.65
Addiction	associated_with	disease	0.65
Schizophrenia	associated_with	disease	0.65
Schizophrenia	activates	disease	0.65
Autism	activates	disease	0.65
Diabetes	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
GENES	associated_with	gene	0.60
Epigenetic	expressed_in	pathway	0.60
Hedgehog	expressed_in	pathway	0.60
ADH1B	associated_with	gene	0.60
CACNA1E	regulates	gene	0.60
DCC	regulates	gene	0.60
TRAF3	regulates	gene	0.60
GRIA1	regulates	gene	0.60
GRM8	regulates	gene	0.60
NCAM1	regulates	gene	0.60
PDE4B	regulates	gene	0.60
FOXK2	associated_with	gene	0.60
FOXN3	associated_with	gene	0.60
AND	associated_with	gene	0.60
CANCER	expressed_in	gene	0.60
DIABETES MELLITUS	expressed_in	gene	0.60
ATF6	associated_with	gene	0.60
MAF	associated_with	gene	0.60
FOXA2	associated_with	gene	0.60
FOXP4	associated_with	gene	0.60
FOXG1	associated_with	gene	0.60
FOXO6	associated_with	gene	0.60
FOXM1	associated_with	gene	0.60

Incoming (52)

Source	Relation	Type	Str
CNTN6	regulates	gene	0.70
OPRM1	associated_with	gene	0.60
DISC1	activates	gene	0.60
CACNA1E	regulates	gene	0.60
DCC	regulates	gene	0.60
GENES	associated_with	gene	0.60
DRD4	associated_with	gene	0.60
CX3CR1	associated_with	gene	0.60
AHR	associated_with	gene	0.60
EP300	associated_with	gene	0.60
JUN	associated_with	gene	0.60
JAK2	associated_with	gene	0.60
CCL20	associated_with	gene	0.60
CD38	associated_with	gene	0.60
PPARG	associated_with	gene	0.60
NOTCH1	associated_with	gene	0.60
SMAD6	associated_with	gene	0.60
NCAM1	regulates	gene	0.60
GRIA1	regulates	gene	0.60
GRM8	regulates	gene	0.60
ESR1	regulates	gene	0.60
PDE4B	regulates	gene	0.60
CANCER	associated_with	gene	0.60
CYTOKINES	associated_with	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60
MICRORNAS	associated_with	gene	0.60
ALZHEIMER DISEASE	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
OVERVIEW	associated_with	gene	0.60
FOXA2	associated_with	gene	0.60
FOXO6	associated_with	gene	0.60
FOXO3	associated_with	gene	0.60
FOXP3	associated_with	gene	0.60
FOXG1	associated_with	gene	0.60
SHH	expressed_in	gene	0.60
FOXP1	associated_with	gene	0.60
FOXM1	associated_with	gene	0.60
FOXP4	associated_with	gene	0.60
FOXO4	associated_with	gene	0.60
FOXO1	associated_with	gene	0.60
RORA	associated_with	gene	0.60
BMP7	associated_with	gene	0.60
ADH1B	associated_with	gene	0.60
FOXK2	associated_with	gene	0.60
FOXD3	associated_with	gene	0.60
FOXN3	associated_with	gene	0.60
CANCER	expressed_in	gene	0.60
DIABETES MELLITUS	expressed_in	gene	0.60
DRD2	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity