gene

PTEN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PTEN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2530Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

PTEN is a gene implicated in neurodegeneration research. Key relationships include: activates, interacts with, associated with. Associated with AD, ALI, ALS. Connected to 1455 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PTEN
Chromosome	10
Function	is a critical tumor suppressor protein that negatively regulates the PI3K/AKT signaling pathway, playing essential roles in neuronal survival, synaptic plasticity, and cellular homeostasis[@pten2021].
Molecular Weight	47 kDa
Amino Acids	403 aa
Pathways	Akt, Angiogenesis, Apoptosis, Autophagy, Chaperone
GeneCards	PTEN
Human Protein Atlas	PTEN
Phosphorylation	Ser380/Thr382/Thr383 phosphorylation inhibits PTEN activity and promotes stability
Oxidation	Reactive oxygen species can transiently inhibit PTEN
Ubiquitination	WWP2-mediated ubiquitination targets PTEN for degradation
Acetylation	p300/CBP-mediated acetylation reduces PTEN function
SUMOylation	Modulates PTEN localization and function
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	circRNA, dimethyl fumarate, metformin, quercetin, rapamycin, RAPAMYCIN
Interactions	ABCD3, ABP, ACETYL-COA, Actin, ACVR1, ADSL
KG Connections	2529 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PTEN["PTEN"] -.->|"inhibits"| PI3K["PI3K"]
    PTEN["PTEN"] -->|"interacts"| Dementia["Dementia"]
    PTEN["PTEN"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    PTEN["PTEN"] -->|"interacts"| Als["Als"]
    PTEN["PTEN"] -->|"interacts"| Alzheimer["Alzheimer"]
    PTEN["PTEN"] -->|"interacts"| Parkinson["Parkinson"]
    CAT["CAT"] -->|"interacts"| PTEN["PTEN"]
    OPTN["OPTN"] -->|"interacts"| PTEN["PTEN"]
    DNM1L["DNM1L"] -->|"interacts"| PTEN["PTEN"]
    CANX["CANX"] -->|"interacts"| PTEN["PTEN"]
    style PTEN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1555)

Target	Relation	Type	Str
PTEN	encodes	protein	0.00
CANCER	activates	gene	1.00
CANCER	therapeutic_target	gene	1.00
Pi3K/Akt	activates	pathway	1.00
MITOCHONDRIA	activates	gene	1.00
Breast Cancer	therapeutic_target	disease	1.00
Mtor	activates	pathway	1.00
Inflammation	activates	disease	1.00
MTOR	activates	gene	1.00
AKT	inhibits	protein	1.00
PARKIN	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
Cancer	associated_with	disease	1.00
PINK1	activates	gene	1.00
PI3K	regulates	gene	1.00
MITOPHAGY	activates	gene	1.00
PI3K	activates	gene	1.00
Autophagy	activates	pathway	1.00
Als	activates	disease	1.00
AKT	therapeutic_target	gene	1.00
Als	inhibits	disease	1.00
AKT	activates	gene	1.00
CANCER	associated_with	gene	1.00
PI3K	inhibits	protein	1.00
Apoptosis	activates	pathway	1.00
GENES	associated_with	gene	1.00
AKT	regulates	gene	1.00
MTOR	regulates	gene	1.00
Tumor	associated_with	disease	1.00
PI3K	therapeutic_target	gene	1.00
Pi3K/Akt	inhibits	pathway	1.00
Neurodegeneration	activates	disease	1.00
Tumor	activates	disease	1.00
Cancer	activates	disease	1.00
Carcinoma	activates	disease	1.00
Parkinson	activates	disease	1.00
Tumor	inhibits	disease	1.00
Cancer	inhibits	disease	1.00
Als	therapeutic_target	disease	1.00
Inflammation	inhibits	disease	1.00
Cancer	therapeutic_target	disease	1.00
Mitophagy	activates	pathway	1.00
Tumor	therapeutic_target	disease	1.00
Als	associated_with	disease	1.00
CANCER	inhibits	gene	1.00
GENES	activates	gene	1.00
Mtor	inhibits	pathway	1.00
APOPTOSIS	activates	gene	1.00
INFLAMMATION	inhibits	gene	1.00
Pi3K/Akt	therapeutic_target	pathway	1.00

Incoming (975)

Source	Relation	Type	Str
PTEN	encodes	gene	0.00
PINK1	activates	gene	1.00
MITOPHAGY	activates	gene	0.98
PARKIN	activates	gene	0.98
AUTOPHAGY	associated_with	gene	0.98
FBXO32	binds_to	protein	0.95
FBXO32	cleaves	protein	0.90
Theranekron	upregulates	drug	0.85
TET1	upregulates	gene	0.85
ALZHEIMER'S DISEASE	associated_with	disease	0.82
AKT	activates	gene	0.82
Structural Variations	associated_with	mechanism	0.80
GABPB1	upregulates	gene	0.80
oncogenic microRNAs	inhibits	protein	0.80
CHD7	coexpressed_with	gene	0.80
oxidation	inhibits	phenotype	0.80
ubiquitination	inhibits	phenotype	0.80
phosphorylation	inhibits	phenotype	0.80
MIRNAS	activates	gene	0.80
MTOR	associated_with	gene	0.74
PI3K	associated_with	gene	0.74
NF-KB	associated_with	protein	0.74
MTOR	activates	gene	0.74
PI3K	activates	gene	0.74
GSK3β	activates	protein	0.70
CANCER	expressed_in	gene	0.70
AGO2	activates	gene	0.70
CANCER	associated_with	gene	0.70
Fyn	acts_upstream_of	protein	0.70
CANCER	regulates	gene	0.70
CANCER	inhibits	gene	0.70
STAT3	activates	gene	0.70
Fyn kinase	regulates	protein	0.70
INFLAMMATION	activates	gene	0.70
circRNA	modulates	drug	0.70
MAP1LC3B	regulates	gene	0.70
OPTN	regulates	gene	0.70
PRKN	regulates	gene	0.70
NLR	regulates	gene	0.70
MIRNAS	therapeutic_target	gene	0.70
DNM1L	biomarker_for	gene	0.70
LC3B	regulates	gene	0.70
Ubiquitination	regulates	mechanism	0.70
NEURODEGENERATION	activates	gene	0.70
CANCER	therapeutic_target	gene	0.70
CALCOCO2	regulates	gene	0.70
EGFR	interacts_with	entity	0.70
fumarate	regulates	process	0.70
LC3	activates	gene	0.66
PARKINSON'S DISEASE	associated_with	disease	0.66

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

neurodegeneration | 2026-04-14 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract shows HDAC9 overexpression reduces Aβ deposition and improves synap

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

Related Research

Hypotheses and analyses mentioning PTEN in their description or question text

No additional research found

PTEN

Understanding Entity Pages

Summary

Wiki Pages (9)

PTEN Protein

DJ-1-PTEN-P53 Network

PTEN Protein

PTEN Protein (Phosphatase and Tensin Homolog)

PINK1 — PTEN Induced Kinase 1

PTEN Signaling in Neurodegeneration

PTEN Gene

PINK1 (PTEN-Induced Kinase 1)

PINK1 — PTEN Induced Kinase 1 (PARK6)