Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Epigenetic: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Epigenetic is a biological pathway involved in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with ALS, Aging, Als. Connected to 1478 entities in the SciDEX knowledge graph.
| Name | Epigenetic |
| Summary | DNA methylation, histone modifications, and non-coding RNA biomarkers in AD, PD, ALS, HD: clinical performance, detection methods, AT(N) integration, and Asian population data |
| Key Genes/Proteins | MTOR, DNA, GENES |
| Related Diseases | Cancer, Tumor, Als, Inflammation |
| Linked Hypotheses | 19 hypotheses |
Knowledge base pages for this entity
graph TD
Epigenetic["Epigenetic"] -->|"interacts"| Autophagy["Autophagy"]
Epigenetic["Epigenetic"] -->|"interacts"| Glycolysis["Glycolysis"]
Epigenetic["Epigenetic"] -->|"interacts"| Ferroptosis["Ferroptosis"]
Epigenetic["Epigenetic"] -->|"interacts"| Apoptosis["Apoptosis"]
Epigenetic["Epigenetic"] -->|"interacts"| Mitophagy["Mitophagy"]
Epigenetic["Epigenetic"] -->|"interacts"| Jak_Stat["Jak-Stat"]
IDH1["IDH1"] -->|"regulates"| Epigenetic["Epigenetic"]
IDH2["IDH2"] -->|"regulates"| Epigenetic["Epigenetic"]
PRMT1["PRMT1"] -->|"therapeutic target"| Epigenetic["Epigenetic"]
PRMT5["PRMT5"] -->|"therapeutic target"| Epigenetic["Epigenetic"]
style Epigenetic fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Autophagy | interacts_with | pathway | 0.55 |
| Glycolysis | interacts_with | pathway | 0.55 |
| Ferroptosis | interacts_with | pathway | 0.55 |
| Apoptosis | interacts_with | pathway | 0.55 |
| Mitophagy | interacts_with | pathway | 0.55 |
| Jak-Stat | interacts_with | pathway | 0.55 |
| Hedgehog | interacts_with | pathway | 0.55 |
| Tgf-Β | interacts_with | pathway | 0.55 |
| Complement | interacts_with | pathway | 0.55 |
| Wnt | interacts_with | pathway | 0.55 |
| Ubiquitin-Proteasome | interacts_with | pathway | 0.55 |
| Immune Response | interacts_with | pathway | 0.55 |
| Mtor | interacts_with | pathway | 0.55 |
| Dna Methylation | interacts_with | pathway | 0.55 |
| Mapk | interacts_with | pathway | 0.55 |
| Insulin Signaling | interacts_with | pathway | 0.55 |
| Synaptic Plasticity | interacts_with | pathway | 0.55 |
| Notch | interacts_with | pathway | 0.55 |
| Stem Cell | therapeutic_target | cell_type | 0.50 |
| Epithelial | therapeutic_target | cell_type | 0.50 |
| T Cell | therapeutic_target | cell_type | 0.50 |
| Neuron | methylates | cell_type | 0.50 |
| T Cell | activates | cell_type | 0.50 |
| Microglia | therapeutic_target | cell_type | 0.50 |
| Neuron | activates | cell_type | 0.50 |
| Dopaminergic | activates | cell_type | 0.50 |
| Cardiomyocyte | activates | cell_type | 0.50 |
| Macrophage | regulates | cell_type | 0.50 |
| Neutrophil | regulates | cell_type | 0.50 |
| Endothelial | regulates | cell_type | 0.50 |
| Stem Cell | associated_with | cell_type | 0.50 |
| Cardiomyocyte | contributes_to | cell_type | 0.50 |
| Neuron | associated_with | cell_type | 0.50 |
| Fibroblast | activates | cell_type | 0.50 |
| Macrophage | activates | cell_type | 0.50 |
| Monocyte | activates | cell_type | 0.50 |
| Epithelial | inhibits | cell_type | 0.50 |
| Radial Glia | therapeutic_target | cell_type | 0.50 |
| Astrocyte | therapeutic_target | cell_type | 0.50 |
| Stem Cell | activates | cell_type | 0.50 |
| T Cell | associated_with | cell_type | 0.50 |
| Stem Cell | regulates | cell_type | 0.50 |
| Neuron | therapeutic_target | cell_type | 0.50 |
| Dopaminergic | therapeutic_target | cell_type | 0.50 |
| Stem Cell | methylates | cell_type | 0.50 |
| Neuron | regulates | cell_type | 0.50 |
| Macrophage | therapeutic_target | cell_type | 0.50 |
| Neuron | contributes_to | cell_type | 0.50 |
| Endothelial | contributes_to | cell_type | 0.50 |
| Stem Cell | contributes_to | cell_type | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MTOR | therapeutic_target | gene | 1.00 |
| Cancer | regulates | disease | 1.00 |
| Tumor | regulates | disease | 1.00 |
| DNA | therapeutic_target | gene | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| GENES | regulates | gene | 1.00 |
| DNA | regulates | gene | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Als | activates | disease | 1.00 |
| GENES | activates | gene | 1.00 |
| DNA | activates | gene | 1.00 |
| Cardiovascular | therapeutic_target | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| GENES | associated_with | gene | 1.00 |
| Als | associated_with | disease | 1.00 |
| DNA | associated_with | gene | 1.00 |
| DNA | inhibits | gene | 1.00 |
| Aging | associated_with | disease | 1.00 |
| Aging | regulates | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| PI3K | therapeutic_target | gene | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| Aging | activates | disease | 1.00 |
| Als | contributes_to | disease | 1.00 |
| OVERVIEW | therapeutic_target | gene | 1.00 |
| Fibrosis | therapeutic_target | disease | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Als | expressed_in | disease | 1.00 |
| MIRNAS | regulates | gene | 1.00 |
| Inflammation | associated_with | entity | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| OXIDATIVE STRESS | regulates | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| APOPTOSIS | regulates | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
epigenetics | 2026-04-15 | 0 hypotheses
neuro-oncology | 2026-04-13 | 0 hypotheses
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.444
gene therapy | 2026-04-11 | 0 hypotheses
behavioral neuroscience | 2026-04-11 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Clonal Hematopoiesis in Nonmalignant Disease: Functional Consequences of Mutated [PMID:40929507] | Koh Y, Tengesdal IW, Jaiswal S | Annu Rev Pathol | 2026 | 1 |
| Single-cell multiregion epigenomic rewiring in Alzheimer's disease progression a [PMID:40752494] | Liu Z, Zhang S, James BT, Galani K, Mang | Cell | 2025 | 1 |
| Utilization of fluid-based biomarkers as endpoints in disease-modifying clinical [PMID:38678292] | Oosthoek M, Vermunt L, de Wilde A, Bonge | Alzheimer's research & therapy | 2024 | 1 |
| TET2 guards against unchecked BATF3-induced CAR T cell expansion. [PMID:36755094] | Jain N, Zhao Z, Feucht J, Koche R, Iyer | Nature | 2023 | 1 |
| Clonal Hematopoiesis of Indeterminate Potential: Current Understanding and Futur [PMID:36928826] | Singh I, Singh A | Curr Oncol Rep | 2023 | 1 |
| Detailed stratified GWAS analysis for severe COVID-19 in four European populatio [PMID:35848942] | Degenhardt F, Ellinghaus D, Juzenas S, L | Human molecular genetics | 2022 | 1 |
| The function and regulation of TET2 in innate immunity and inflammation. [PMID:33085059] | Cong B, Zhang Q, Cao X | Protein Cell | 2021 | 1 |
| Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Hom [PMID:29548672] | Datta M, Staszewski O, Raschi E, Frosch | Immunity | 2018 | 1 |
| Depression as a risk factor for Alzheimer's disease: Genes, steroids, cytokines [PMID:26746105] | Herbert J, Lucassen PJ | Frontiers in neuroendocrinolog | 2016 | 1 |
| Global epigenomic reconfiguration during mammalian brain development. [PMID:23828890] | Lister R, Mukamel EA, Nery JR, Urich M, | Science | 2013 | 1 |
| Homoplantaginin ameliorates osteoarthritis by activating Sirt3/PINK1/Parkin sign [PMID:41720004] | Zhang H, Xiao J, Yi Y, Chen B, Lv W et a | Phytomedicine | 2026 | 0 |
| Kakkalide promotes spinal cord injury repair by regulating microglial M2 polariz [PMID:41720005] | You T, Dai B, Ding X, He Z, Peng J et al | Phytomedicine | 2026 | 0 |
| α7-nAChR activation mitigates pyridaben-induced hepatotoxicity in grass carp (Ct [PMID:41966317] | Wu C, Jiang J, Qiu H, Xie J, Li S | Fish Shellfish Immunol | 2026 | 0 |
| Targeting synaptic plasticity and acetylcholine dysregulation in the medial pref [PMID:41014339] | Shi J, Chen M, Zhang Y, Fan X, Wang L et | Psychopharmacology (Berl) | 2026 | 0 |
| NAD+ subcellular partitioning mediated by miR-183 and miR-96 regulates muscle st [PMID:41915008] | Ma M, Ma R, Li Z, Shen S, Kong W, Qiu T, | Journal of molecular cell biol | 2026 | 0 |
| Rhodiola sacra Protects Against Hippocampal Neuronal Apoptosis in Chronic Cerebr [PMID:41879438] | Zhou L, Jia J, Li J, Yao Z, Fu Z, Wang S | Current neuropharmacology | 2026 | 0 |
| Mechanistic Modulation of Autophagy by Bioactive Natural Products: Implications [PMID:41830033] | Jalouli M, Harrath AH, Al-Zharani M, Rah | Nutrients | 2026 | 0 |
| Mechanistic advances in exercise‑mediated regulation of autophagy dysfunction in [PMID:41645754] | Li W, Wang WH, Song Y, Li XJ, Li Y et al | Int J Mol Med | 2026 | 0 |
| Unravelling the therapeutic potential of chrysin against ischemic stroke and pos [PMID:41687709] | Achar PG, Krishna KL, C P K, Patil M, Pr | Neuroscience | 2026 | 0 |
| Loss of REST associated with Alzheimer's disease pathology is ameliorated by NAD [PMID:41709697] | Lagartos-Donate MJ, Escobar-Doncel B, Zh | Brain | 2026 | 0 |