gene

LHX2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about LHX2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

LHX2 transcription factor critical for forebrain development, hippocampal formation, olfactory system, and adult neurogenesis. Associated with neurodegeneration, neurodevelopmental disorders, and cognitive decline.

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🧬 Gene Info

Gene Symbol	LHX2
Full Name	LIM Homeobox 2
Chromosome	9q31.3
Protein Type	Gene
Function	is a LIM-type homeobox transcription factor that plays critical roles in the development and maintenance of the nervous system.
Subcellular Localization	The LIM domains contain zinc-finger motifs that coordinate zinc ions, creating a stable protein fold
Molecular Weight	45 kDa
Amino Acids	406 aa
GeneCards	LHX2
Human Protein Atlas	LHX2
Linker region	Connects the LIM domains to the homeodomain, contains regulatory sequences
Ldb1/Ldb2	Co-factors that form complexes with LIM proteins
Clim/NLI	Nuclear co-factors that enhance transcriptional activity
RORβ	Nuclear receptor involved in cortical development
Bmp signaling molecules	Regulates LHX2 expression in developing cortex
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

LHX2 — LIM Homeobox 2

gene · 2595 words

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Pathway Diagram

graph TD
    LHX2["LHX2"]
    neurodegeneration["neurodegeneration"]
    LHX2 -->|"implicated_in"| neurodegeneration
    style LHX2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning LHX2 in their description or question text

No additional research found