Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LHX2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
LHX2 transcription factor critical for forebrain development, hippocampal formation, olfactory system, and adult neurogenesis. Associated with neurodegeneration, neurodevelopmental disorders, and cognitive decline.
| Gene Symbol | LHX2 |
| Full Name | LHX2 — LIM Homeobox 2 |
| Chromosome | 9q31.3 |
| Protein Type | Gene |
| Function | is a LIM-type homeobox transcription factor that plays critical roles in the development and maintenance of the nervous system. |
| Subcellular Localization | The LIM domains contain zinc-finger motifs that coordinate zinc ions, creating a stable protein fold |
| Molecular Weight | 45 kDa |
| Amino Acids | 406 aa |
| NCBI Gene ID | Search NCBI |
| GeneCards | LHX2 |
| Human Protein Atlas | LHX2 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
LHX2["LHX2"]
neurodegeneration["neurodegeneration"]
LHX2 -->|"implicated_in"| neurodegeneration
style LHX2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||