protein

LIFRPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LIFRPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Experiments

0Debates

Summary

Lif Receptor Protein Leukemia Inhibitory Factor Receptor plays an important role in the study of neurodegenerative diseases.

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🔬 Protein Info

Gene Symbol	LIFRPROTEIN
Chromosome	5p13.1
Protein Type	Receptor
Function	is a critical cytokine receptor that mediates the effects of leukemia inhibitory factor (LIF) and related cytokines of the interleukin-6 (IL-6) family.
Molecular Weight	~190 kDa (full-length)
Amino Acids	800 aa
Exons	20
UniProt ID	P30203
GeneCards	LIFRPROTEIN
Human Protein Atlas	LIFRPROTEIN
Full-length LIFR (LIFRα)	Membrane-bound receptor with full signaling capacity
Soluble LIFR (sLIFR)	Truncated isoform generated by alternative splicing or proteolytic cleavage; acts as a natural antagonist by sequestering LIF
Associated Diseases	neurodegeneration
Interactions	BDNF, BRD4, CANCER, EP300, JAK1, LIF
KG Connections	32 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: LIFRPROTEIN — AlphaFold P30203 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

LIF Receptor Protein - Leukemia Inhibitory Factor Receptor

protein · 2026 words

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Pathway Diagram

graph TD
    LIFRPROTEIN["LIFRPROTEIN"]
    neurodegeneration["neurodegeneration"]
    LIFRPROTEIN -->|"implicated_in"| neurodegeneration
    style LIFRPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LIFRPROTEIN in their description or question text

No additional research found