gene

EP300

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EP300: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

578Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

EP300 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, regulates. Associated with Aging, Als, Alzheimer. Connected to 390 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	EP300
Chromosome	22q13.2
Protein Type	Transferase
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Ubiquitous, highest in brain
Molecular Weight	~300 kDa
Amino Acids	414 aa
Pathways	NF-κB
GeneCards	EP300
Human Protein Atlas	EP300
Protein Size	2,414 amino acids
Approach	Mechanism
HDAC Inhibitors	Increase histone acetylation
CBP/p300-specific inhibitors	Modulate transcription
Small molecule activators	Enhance p300 activity
Associated Diseases	Als, Alzheimer, Autoimmune, CANCER, Carcinoma
Known Drugs/Compounds	Acetyl-CoA, rapamycin
Interactions	FGFR3, TCF3, IGF2BP2, CSF1R, SMAD3, BRD4
KG Connections	578 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    EP300["EP300"] -->|"Regulates"| histone_H2B_acetylation["histone H2B acetylation"]
    EP300["EP300"] -->|"Associated With"| Tumor["Tumor"]
    EP300["EP300"] -->|"Associated With"| Parkinson["Parkinson"]
    EP300["EP300"] -->|"Therapeutic Target"| Glioblastoma["Glioblastoma"]
    EP300["EP300"] -->|"Therapeutic Target"| Cancer["Cancer"]
    EP300["EP300"] -->|"Therapeutic Target"| Ms["Ms"]
    EP300["EP300"] -->|"Therapeutic Target"| Fibrosis["Fibrosis"]
    EP300["EP300"] -->|"Therapeutic Target"| Hepatitis["Hepatitis"]
    OPTN["OPTN"] -->|"Associated With"| EP300["EP300"]
    ULK1["ULK1"] -->|"Associated With"| EP300["EP300"]
    CALCOCO2["CALCOCO2"] -->|"Associated With"| EP300["EP300"]
    HSPA8["HSPA8"] -->|"Associated With"| EP300["EP300"]
    STX17["STX17"] -->|"Associated With"| EP300["EP300"]
    style EP300 fill:#8d4900,color:#e0e0e0
    style histone_H2B_acetylation fill:#1b5e20,color:#e0e0e0
    style Tumor fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Glioblastoma fill:#b71c1c,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Fibrosis fill:#b71c1c,color:#e0e0e0
    style Hepatitis fill:#b71c1c,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style ULK1 fill:#8d4900,color:#e0e0e0
    style CALCOCO2 fill:#8d4900,color:#e0e0e0
    style HSPA8 fill:#8d4900,color:#e0e0e0
    style STX17 fill:#8d4900,color:#e0e0e0

Outgoing (371)

Target	Relation	Type	Str
Histone Acetylation	regulates	process	0.90
RPTOR	phosphorylates	protein	0.85
ESR1	interacts_with	protein	0.80
Cancer	therapeutic_target	disease	0.75
Cancer	expressed_in	disease	0.75
Tumor	expressed_in	disease	0.75
histone H2B acetylation	regulates	process	0.70
SIRT1	interacts_with	gene	0.70
epigenetic regulation	participates_in	pathway	0.70
MAPK signaling	participates_in	pathway	0.70
PI3K	co_discussed	gene	0.65
STAT3	co_discussed	gene	0.65
neurodegeneration	co_discussed	concept	0.65
Tumor	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Dementia	interacts_with	disease	0.65
Hepatitis	associated_with	disease	0.65
Glioblastoma	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Obesity	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Fibrosis	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Leukemia	associated_with	disease	0.65
Autoimmune	associated_with	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Tumor	activates	disease	0.65
Cancer	regulates	disease	0.65
Ms	activates	disease	0.65
Tumor	inhibits	disease	0.65
Aging	activates	disease	0.65
Leukemia	activates	disease	0.65
Migraine	associated_with	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	activates	disease	0.65
Leukemia	therapeutic_target	disease	0.65

Incoming (207)

Source	Relation	Type	Str
CBX3	interacts_with	protein	0.93
Acetyl-CoA	activates	compound	0.90
CBX3	binds	gene	0.90
P53	expressed_in	gene	0.70
CANCER	expressed_in	gene	0.70
AKT	co_discussed	gene	0.65
OPTN	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
STX17	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
KAT8	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
RB1	associated_with	gene	0.60
KAT2B	associated_with	gene	0.60
KAT5	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
CREBBP	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
HSP70	associated_with	gene	0.60
NDP52	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
RB1	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
FGF20	therapeutic_target	gene	0.60
BRG1	regulates	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
BECN1	co_discussed	gene	0.60
CREBBP	co_discussed	gene	0.60
ALDH1A1	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60
LEF1	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
CLDN1	therapeutic_target	gene	0.60
JAG1	therapeutic_target	gene	0.60
CTNNB1	regulates	gene	0.60
AXIN1	regulates	gene	0.60
TP53	therapeutic_target	gene	0.60
SRC	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

EP300

Understanding Entity Pages

Summary

Wiki Pages (21)

EP300 Gene

CBS/PSP Treatment Rankings

Kabuki Syndrome

Mitophagy Pathway in Neurodegeneration

Epigenetic Dysregulation in Neurodegeneration

rapamycin-tauopathy

tudca-udca-neurodegeneration

Longevity and Rejuvenation Therapies Landscape

autophagy-lysosome-dysfunction

Senolytic Therapies for CBS and [PSP](/diseases/progressive-supranuclear-palsy)

Section 189: Advanced Autophagy-Endolysosomal Pathway Therapy in CBS/PSP

Progressive Supranuclear Palsy (PSP) Treatment Guide

Progressive Supranuclear Palsy (PSP) Treatment

Section 244: Advanced Autophagy Induction and TFEB Activation in CBS/PSP

PDLIM7 Epigenetic Activation in Parkinson's Disease

Autophagy Enhancement for Tauopathy

ESRRG Gene

Section 102: Proteostasis Network Dysregulation in CBS/PSP

Proteostasis Therapy CBS PSP