gene

LIN7C

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LIN7C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

LIN7C encodes a synaptic scaffolding protein essential for neuronal polarity, synapse formation, and protein trafficking. Dysregulation contributes to neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	LIN7C
Function	The LIN7C gene encodes LIN-7 Homolog C, a member of the LIN7 family of proteins (also known as VELI or MAGUK proteins).
Primary Expression	both neuronal and non-neuronal tissues
Subcellular Localization	synaptic compartments, where they function as crucial organizers of postsynaptic density (PSD) architecture[@bhattachary
Amino Acids	211 aa
Ensembl ID	ENSG00000114854
GeneCards	LIN7C
Human Protein Atlas	LIN7C
C-terminal region	This region contains targeting signals that direct LIN7C to specific subcellular compartments, particularly dendritic spines and postsynaptic densities.
AMPA receptor subunits	LIN7C binds to the C-terminal tails of GluA1, GluA2, and GluA3 subunits, facilitating proper synaptic localization and trafficking of AMPA receptors
NMDA receptor subunits	Interactions with NR2A and NR2B subunits position LIN7C in postsynaptic densities
Metabotropic glutamate receptors	Links to Group I mGluRs (mGluR1, mGluR5)
PSD-95	Forms complexes that anchor receptors to the postsynaptic density
SAP97	Participates in dendritic targeting of proteins
CASK	LIN7 interacts with this presynaptic partner for trans-synaptic signaling
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    LIN7C["LIN7C"]
    neurodegeneration["neurodegeneration"]
    LIN7C -->|"implicated_in"| neurodegeneration
    style LIN7C fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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