Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LRP1-Dependent Tau Uptake Disruption: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's Disease | therapeutic_target | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| LRP1 | regulates | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| LRP1-Dependent Tau Uptake Disruption | 0.437 | Alzheimer's Disease | Tau propagation mechanisms and therapeut |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.487
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Modulating LRP1 Pathways in Alzheimer's Disease: Mechanistic Insights and Emergi [PMID:41772271] | Mushtaq T, Hameed H, Khan MA, Tariq U, H | Molecular neurobiology | 2026 | 0 |
| Insulin-like growth factor-1 enhances β-amyloid protein clearance in HMC3 microg [PMID:41621577] | Guo H, Peng X, Zhang X, Ruganzu JB, Wu X | Experimental cell research | 2026 | 0 |
| Osteoclast-secreted galectin-3 promotes articular cartilage degeneration in OVX [PMID:40609733] | Chen L, Hong H, Yang Z, Zhong Y, Sun S e | Osteoarthritis Cartilage | 2026 | 0 |
| Small-molecule PCSK9 inhibition enhances BBB amyloid-β clearance and suppresses [PMID:41927877] | Miao J, Wang J, Zhou W, Guo J | Sci Rep | 2026 | 0 |
| Targeting the HDAC4-NHE6-endosomal pH axis restores amyloid-β clearance and cogn [PMID:41933339] | Huang N, Hong R, Cui X, Cao L, Shi L et | J Nanobiotechnology | 2026 | 0 |
| Chicoric acid enhanced brain cholesterol efflux and reduced Aβ pathology via LXR [PMID:41934727] | Li D, Zhang Y, Wang R, Jin L, Cui X et a | Neurotherapeutics | 2026 | 0 |
| Brain and Liver Dual-Targeting Oridonin Nanoparticles to Enhance Aβ Clearance fo [PMID:41944296] | Gong W, Hui W, Qiao S, Ji Q, Liu M et al | Adv Sci (Weinh) | 2026 | 0 |
| Efficient amyloid-β degradation in Alzheimer's disease using SPYTACs. [PMID:41785850] | Teng F, Liu J, Cui T, Tan X, Liu K, Hou | Cell | 2026 | 0 |
| Lysosomal trafficking markers covering PSAP, PGRN, SORT1 and LRP1 in body liquid [PMID:41579784] | Poniatowski ŁA, Siwińska A, Acewicz A, K | Forensic science international | 2026 | 0 |
| Mitochondrial calcium uniporter knockdown in hippocampal neurons effectively att [PMID:41687804] | Wu L, Hou F, Wang Z, Wu M, Wang X, Cao J | Experimental neurology | 2026 | 0 |
| Integrative bioinformatics frameworks for abdominal aortic aneurysm using GWAS m [PMID:40595262] | Sagulkoo P, Chuntakaruk H, Suratanee A, | Scientific reports | 2025 | 0 |
| Inhibition of tau neuronal internalization using anti-tau single domain antibodi [PMID:40175345] | ["Danis C", "Dupr\u00e9 E", "Bouillet T" | Nature communications | 2025 | 0 |
| Schwann cell Lrp1 deletion drives trigeminal neuron sensitization and orofacial [PMID:41430102] | Gong Z, Zhang M, Liu N, Asam K, Martellu | The journal of headache and pa | 2025 | 0 |
| Ganglioside sialylation modulates tau internalization and pathology spread. [PMID:41398374] | Li S, Chen Y, Song T, Liu D, Wu R, Yang | Molecular psychiatry | 2025 | 0 |
| Microglia internalize tau monomers and fibrils using distinct receptors but simi [PMID:39713861] | Falkon KF, Danford L, Gutierrez Kuri E, | Alzheimer's & dementia : the j | 2025 | 0 |
| Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain isc [PMID:38906140] | Zhou J, Zhang L, Peng J, Zhang X, Zhang | Cell metabolism | 2024 | 0 |
| Mitochondrial NADK2-dependent NADPH controls Tau oligomer uptake in human neuron [PMID:39554169] | Pardo E, Kim T, Wallrabe H, Zengeler KE, | bioRxiv : the preprint server | 2024 | 0 |
| The role of neutrophils in tPA thrombolysis after stroke: a malicious troublemak [PMID:39606238] | Li Q, Ye J, Li Z, Xiao Q, Tan S, Hu B, J | Frontiers in immunology | 2024 | 0 |
| Ancient gene linkages support ctenophores as sister to other animals. [PMID:37198475] | ["Schultz D", "Haddock S", "Bredeson J", | Nature | 2023 | 0 |
| Pan-cancer T cell atlas links a cellular stress response state to immunotherapy [PMID:37248301] | ["Chu Y", "Dai E", "Li Y", "Han G", "Pei | Nature medicine | 2023 | 0 |