disease

Lung Cancer Brain Metastasis

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Lung Cancer Brain Metastasis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

0Analyses

0Outgoing

17Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	TP53, EGFR, TTN, MUC16
Therapeutic Agents	Gamitrinib, Anti-PD-1 Immunotherapy
KG Connections	17 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (1)

Knowledge base pages for this entity

Oxidative Phosphorylation (OXPHOS)

pathway · 635 words

→

Pathway Diagram

graph TD
    Mitochondrial_Specific_Metabol["Mitochondrial-Specific Metabolism"] -->|"associated"| Lung_Cancer_Brain_Metastasis["Lung Cancer Brain Metastasis"]
    style Mitochondrial_Specific_Metabol fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Early_Metastatic_Epithelial_Ce["Early Metastatic Epithelial Cell Clusters"] -->|"associated"| Lung_Cancer_Brain_Metastasis["Lung Cancer Brain Metastasis"]
    style Early_Metastatic_Epithelial_Ce fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Tumor_Immune_Microenvironment["Tumor Immune Microenvironment"] -->|"regulates"| Lung_Cancer_Brain_Metastasis["Lung Cancer Brain Metastasis"]
    style Tumor_Immune_Microenvironment fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    TP53["TP53"] -->|"biomarker for"| Lung_Cancer_Brain_Metastasis["Lung Cancer Brain Metastasis"]
    style TP53 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    EGFR["EGFR"] -->|"biomarker for"| Lung_Cancer_Brain_Metastasis["Lung Cancer Brain Metastasis"]
    style EGFR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Lung_Cancer_Brain_Metastasis fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (17)

Source	Relation	Type	Str
Mitochondrial-Specific Metabolism	associated_with	pathway	0.95
Early Metastatic Epithelial Cell Clusters	associated_with	cell_type	0.95
Mitochondrial-Specific Metabolism	upregulates	pathway	0.95
Tumor Immune Microenvironment	downregulates	process	0.95
TP53	biomarker_for	gene	0.90
EGFR	biomarker_for	gene	0.90
Oxidative Phosphorylation	involved_in	pathway	0.90
TP53	associated_with	gene	0.90
EGFR	associated_with	gene	0.90
Gamitrinib	treats	drug	0.85
Anti-PD-1 Immunotherapy	treats	drug	0.85
Mitochondrial Metabolism Genes	biomarker_for	biomarker	0.85
Immune Genes	biomarker_for	biomarker	0.85
TTN	associated_with	gene	0.85
MUC16	associated_with	gene	0.85
Intra-Tumor Heterogeneity	associated_with	phenotype	0.85
Focal Amplification 5P15.33	associated_with	biomarker	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found