Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TTN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | TTN |
| Key Genes/Proteins | CAMK2D, CANCER, EGFR, TP53, AND |
| Related Diseases | Myofibrillar Myopathy, Lung Cancer Brain Metastasis, Ms, Als, Cancer |
Knowledge base pages for this entity
graph TD
TTN["TTN"]
TTN -->|"causes"| Myofibrillar_Myopathy["Myofibrillar Myopathy"]
TTN -->|"target for"| Ms["Ms"]
TTN -->|"target for"| Tumor["Tumor"]
TTN -->|"target for"| Oxidative_Phosphorylation["Oxidative Phosphorylation"]
TTN -->|"target for"| Apoptosis["Apoptosis"]
CAMK2D["CAMK2D"] -->|"regulates"| TTN
APOPTOSIS["APOPTOSIS"] -->|"target for"| TTN
RNA["RNA"] -->|"target for"| TTN
PD_1["PD-1"] -->|"activates"| TTN| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Myofibrillar Myopathy | causes | disease | 0.95 |
| Lung Cancer Brain Metastasis | associated_with | disease | 0.85 |
| Ms | therapeutic_target | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Tumor | therapeutic_target | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| CANCER | associated_with | gene | 0.60 |
| EGFR | associated_with | gene | 0.60 |
| TP53 | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| LRP1B | associated_with | gene | 0.60 |
| RYR2 | associated_with | gene | 0.60 |
| Oxidative Phosphorylation | therapeutic_target | pathway | 0.60 |
| Apoptosis | therapeutic_target | pathway | 0.60 |
| BRCA1 | associated_with | gene | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| Proteasome | associated_with | pathway | 0.60 |
| Oxidative Phosphorylation | activates | pathway | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| SQSTM1 | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| RNA | therapeutic_target | gene | 0.60 |
| APOPTOSIS | therapeutic_target | gene | 0.60 |
| Egfr | associated_with | protein | 0.60 |
| P53 | associated_with | protein | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| Ca1 | expressed_in | brain_region | 0.55 |
| benchmark_ot_ad_answer_key:TTN | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| CAMK2D | regulates | gene | 0.90 |
| GENES | associated_with | gene | 0.60 |
| APOPTOSIS | therapeutic_target | gene | 0.60 |
| DNAJB6 | associated_with | gene | 0.60 |
| SQSTM1 | associated_with | gene | 0.60 |
| FLNC | associated_with | gene | 0.60 |
| NBR1 | associated_with | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| MYOT | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| P62 | associated_with | gene | 0.60 |
| DES | associated_with | gene | 0.60 |
| RYR2 | associated_with | gene | 0.60 |
| TP53 | associated_with | gene | 0.60 |
| RNA | therapeutic_target | gene | 0.60 |
| LRP1B | associated_with | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| PD-1 | activates | gene | 0.60 |
| EGFR | associated_with | gene | 0.60 |
| RNA | activates | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| BRCA1 | associated_with | gene | 0.60 |
| MUC16 | associated_with | gene | 0.60 |
| benchmark_ot_ad_answer_key:TTN | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||