Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MARCHF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Membrane-Associated RING-CH Finger 1 - E3 ubiquitin ligase involved in immune regulation and membrane trafficking
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| Gene Symbol | MARCHF1 |
| Aliases | Membrane-Associated RING-CH Finger 1 |
| Protein Type | Ligase |
| Function | is a membrane-associated E3 ubiquitin ligase belonging to the MARCH family of RING-CH (Really Interesting New Gene-CH) domain-containing proteins. |
| Primary Expression | immune cells but has emerging roles in neuroinflammation and neurodegeneration |
| Pathways | Notch |
| GeneCards | MARCHF1 |
| Human Protein Atlas | MARCHF1 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
MARCHF1["MARCHF1"]
neurodegeneration["neurodegeneration"]
MARCHF1 -->|"implicated_in"| neurodegeneration
style MARCHF1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MARCHF1 in their description or question text
No additional research found