Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about METABOLIC_REPROGRAMMING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| anti-inflammatory microglial phenotypes | causes | phenotype | 0.70 |
| chronic neuroinflammation | associated_with | phenotype | 0.70 |
| CELLULAR_SENESCENCE | determines | phenotype | 0.64 |
| oxidative_stress | regulates | phenotype | 0.56 |
| MYOCARDIAL_FIBROSIS | contributes_to | phenotype | 0.56 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HIF1A | activates | gene | 0.90 |
| HIF-1alpha | regulates | protein | 0.70 |
| TME | activates | phenotype | 0.64 |
| HIF1A | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-25 | 12 hypotheses Top: 0.895
neurodegeneration | 2026-04-02 | 6 hypotheses
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.480
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Clinical outcome analysis based on IDH mutation status | clinical | gliomas | 0.850 | 0.00 | human patients | proposed | N/A |
| Proposed experiment from debate on Astrocytes adopt A1 (neurotoxic) an | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | completed | $100,000 |
| Proposed experiment from debate on Microglia activate astrocytes via I | falsification | Neuroinflammation | 0.400 | 0.50 | cell_line | completed | $80,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Saturation mutagenesis of twenty disease-associated regulatory elements at singl [PMID:31395865] | ["Kircher M", "Xiong C", "Martin B", "Sc | Nature Communications | 2019 | 267 |
| Bergenin attenuates traumatic brain injury via inhibition of microglial PFKFB3-d [PMID:41520557] | Sun B, Zhang A, Feng S, Jamali AW, Jia Z | Int Immunopharmacol | 2026 | 1 |
| HK1 and HK2 Beyond Glycolysis: Mitochondrial Interactions and Dual Roles in Meta [PMID:41387352] | Pesce NA, Seminara G, Giarrusso G, Tomas | Adv Biol (Weinh) | 2026 | 1 |
| Glucose Metabolic Reprogramming in Microglia: Implications for Neurodegenerative [PMID:39987285] | Fang M, Zhou Y, He K, Lu Y, Tao F, Huang | Mol Neurobiol | 2025 | 1 |
| Deficiency of Microglial Hv1 Protects Against Lipopolysaccharide-Induced Neuroin [PMID:40911376] | Sun L, Wang X, Guan S, Zhang P, Chen D, | FASEB J | 2025 | 1 |
| The PI3K/Akt Pathway and Glucose Metabolism: A Dangerous Liaison in Cancer. [PMID:38904014] | Fontana F, Giannitti G, Marchesi S, Limo | Int J Biol Sci | 2024 | 1 |
| AST-120 alleviates renal ischemia-reperfusion injury by inhibiting HK2-mediated [PMID:39217289] | Zhou J, Zhang J, Xu F, Gao H, Wang L, Zh | Mol Med | 2024 | 1 |
| Hexokinase 2-mediated gene expression via histone lactylation is required for he [PMID:37463576] | Rho H, Terry AR, Chronis C, Hay N | Cell Metab | 2023 | 1 |
| IDH2 stabilizes HIF-1α-induced metabolic reprogramming and promotes chemoresista [PMID:36637036] | Shigeta K, Hasegawa M, Hishiki T, Naito | EMBO J | 2023 | 1 |
| NAD(+) metabolism, stemness, the immune response, and cancer. [PMID:33384409] | Navas LE, Carnero A | Signal Transduct Target Ther | 2021 | 1 |
| Cancer-associated mutation and beyond: The emerging biology of isocitrate dehydr [PMID:31131326] | Tommasini-Ghelfi S, Murnan K, Kouri FM, | Sci Adv | 2019 | 1 |
| Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcino [PMID:28622513] | Cancer Genome Atlas Research Network. El | Cell | 2017 | 1 |
| Diagnostic, prognostic and predictive relevance of molecular markers in gliomas. [PMID:25944653] | Brandner S, von Deimling A | Neuropathol Appl Neurobiol | 2015 | 1 |
| IDH1 and IDH2 mutations in gliomas. [PMID:19228619] | Yan H, Parsons DW, Jin G, McLendon R, Ra | N Engl J Med | 2009 | 1 |
| Modulating LRP1 Pathways in Alzheimer's Disease: Mechanistic Insights and Emergi [PMID:41772271] | Mushtaq T, Hameed H, Khan MA, Tariq U, H | Molecular neurobiology | 2026 | 0 |
| Crosstalk Between [PMID:41899603] | ["Ren Y", "Tang D", "Ding X", "He M"] | Cancers | 2026 | 0 |
| Resibufogenin protects against atherosclerosis in ApoE(-/-) mice through blockin [PMID:40258472] | Xiaoyang C, Yijun C, Chenguang Z, Wanyin | J Adv Res | 2026 | 0 |
| High- and Low-Fat Dairy Consumption and Long-Term Risk of Dementia: Evidence Fro [PMID:41406402] | Du Y, Borné Y, Samuelsson J, Glans I, Hu | Neurology | 2026 | 0 |
| Macrophage-Specific E3 Ubiquitin Ligase TRIM31 Reduces Atherosclerotic Plaque Fo [PMID:41410044] | Zhang J, Yu L, Yang W, Cao L, Wang X et | Circulation | 2026 | 0 |
| The role of astrocytes in Alzheimer's disease: Pathophysiology, biomarkers, and [PMID:41527736] | Abedin MJ, Kastanenka KV | J Alzheimers Dis | 2026 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.65 · 2026-04-25
closed · Rounds: 4 · Score: 0.95 · 2026-04-15
closed · Rounds: 4 · Score: 0.95 · 2026-04-06
Hypotheses and analyses mentioning METABOLIC_REPROGRAMMING in their description or question text
Score: 0.643 · neurodegeneration · 2026-04-13
## Mechanistic Overview Cell-Type Specific Metabolic Reprogramming starts from the claim that modulating PPARA within th
Score: 0.643 · neurodegeneration · 2026-04-07
## Mechanistic Overview SASP-Driven Microglial Metabolic Reprogramming in Synaptic Phagocytosis starts from the claim th
Score: 0.636 · neurodegeneration · 2026-04-04
## Mechanistic Overview Astrocyte Metabolic Reprogramming via APOE4 Correction starts from the claim that modulating APO
Score: 0.631 · neurodegeneration · 2026-04-12
## Mechanistic Overview Disease-Associated Microglia Metabolic Reprogramming starts from the claim that modulating TREM2
Score: 0.602 · neurodegeneration · 2026-04-17
## Mechanistic Overview NRF2-Mediated Metabolic Reprogramming: HBOT as Direct NAMPT/SIRT1 Activator for Reverse Senescen
Score: 0.599 · neurodegeneration · 2026-04-02
## Mechanistic Overview Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Circuits starts from the claim that mo
Score: 0.580 · neuroscience · 2026-04-22
**Molecular Mechanism and Rationale** The APOE4-driven metabolic reprogramming of astrocytes represents a complex casca
Score: 0.550 · neurodegeneration · 2026-04-02
## Mechanistic Overview Digital Twin-Guided Metabolic Reprogramming starts from the claim that modulating PPARGC1A/PRKAA
Score: 0.494 · neuroscience · 2026-04-21
## Mechanistic Overview TREM2-Mediated Microglial Metabolic Reprogramming Accelerates Tau Pathological Spread starts fro
Score: 0.486 · neurodegeneration · 2026-04-04
## Molecular Mechanism and Rationale Oligodendrocyte progenitor cells (OPCs) undergo a critical metabolic transformatio
Score: 0.480 · neurodegeneration · 2026-04-27
Combinatorial targeting of TREM2, APOE, and CLU network with metabolic reprogramming toward anti-inflammatory microglial
Score: 0.455 · chronobiology · 2026-04-27
Timed delivery of NAD+ precursors and AMPK activators to reset microglial circadian metabolism from glycolytic pro-infla
Score: 0.455 · neuroinflammation · 2026-04-27
SPI1 transcriptionally coordinates both inflammatory gene expression and metabolic enzymes in activated microglia, shift
Score: 0.450 · neurodegeneration · 2026-04-21
## Mechanistic Overview Metabolic Reprogramming Toward GAPDH Inhibition starts from the claim that modulating GAPDH, HK2
Score: 0.390 · als · 2026-04-26
TBK1 loss-of-function mutations in ALS disrupt microglial metabolic homeostasis by impairing mTOR-dependent metabolic ch