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entity

TME

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TME: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections
30Hypotheses
0Analyses
2Outgoing
0Incoming
1Experiments
0Debates

No AI portrait yet

Wiki Pages (20)

Knowledge base pages for this entity

TMEM175 Protein

protein · 2968 words
→

TMEM163 — Transmembrane Protein 163

gene · 2847 words
→

TMEM230 Gene

gene · 2376 words
→

TMEM55B — Transmembrane Protein 55B

gene · 2210 words
→

TMEM175 Lysosomal Overflow Valve in Parkinson's Disease

mechanism · 1994 words
→

Outgoing (2)

TargetRelationTypeStr
METABOLIC_REPROGRAMMINGactivatesphenotype0.64
PHOSPHOLIPID_METABOLISMregulatespathway0.56

Incoming (0)

SourceRelationTypeStr
No incoming edges

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Closed-loop transcranial focused ultrasound to restore hippo 0.865 alzheimers Circuit-level neural dynamics in neurode
H2: Impaired Autophagy Receptor Recruitment Traps G3BP1 Gran 0.737 neurodegeneration How do pathological stress granules tran
G2019S Acts as Lysosomal Volume-Sensing Amplifier via Enhanc 0.730 neurodegeneration Do pathogenic LRRK2 mutations amplify vo
TDP-43 condensation thermodynamics as a therapeutic target a 0.724 neuroscience How can subcellular compartmentalization
C9orf72 ASO Treatment Reverses TDP-43 Pathology in ALS/FTD 0.720 neurodegeneration Test Hypothesis Fixtures
Glucosylceramide Accumulation from GCase Deficiency Disrupts 0.700 neurodegeneration -
SNCA Aggregation Hijacks the Endosomal Sorting Complex Requi 0.690 neurodegeneration -
TREM2-APOE Axis Manipulation via APOE Lipidation for DAM Rec 0.685 neurodegeneration Microglial subtypes in neurodegeneration
Retromer-dependent retrograde endosomal signaling compartmen 0.645 neuroscience How can subcellular compartmentalization
Colonic Th17/IL-17A Axis → Peripheral Immune Recruitment to 0.640 neurodegeneration What are the mechanisms by which gut mic
HDAC3-Dependent A1 Astrocyte Commitment Window 0.611 neurodegeneration What is the optimal therapeutic window d
Multi-Biomarker Composite Index Surpassing Amyloid PET for T 0.579 neurodegeneration Multi-modal Biomarker Panel Design for E
Dynamic Microglial Phenotype Switching Biomarker Panel for N 0.577 neurodegeneration What amyloid threshold level is required
A genetically encoded reporter for axonal mitochondrial prot 0.565 neuroscience How can subcellular compartmentalization
TFEB Activation Clears Tau-Loaded Endolysosomal Compartments 0.560 neurodegeneration Investigate prion-like spreading of tau
Sticker-Spacer Phase Behavior Determines Recruitment Hierarc 0.556 molecular-biology What physicochemical properties determin
Optogenetic restoration of hippocampal gamma oscillations vi 0.555 alzheimers Circuit-level neural dynamics in neurode
Combined p-tau217 + p-tau231 Panel Increases Specificity for 0.546 neurodegeneration -
Charge-Pattern Asymmetry Creates Electrostatic Recruitment G 0.523 molecular-biology What physicochemical properties determin
CSF p-tau217 Threshold of <0.15 pg/mL Predicts Durable Clini 0.512 neurodegeneration -
Rational design of small molecules targeting TDP-43 liquid-t 0.510 neurodegeneration Test
Sonic hedgehog pathway compartmentalization as quantitative 0.485 neuroscience How can subcellular compartmentalization
CNS-Peripheral Cytokine Compartmentalization 0.455 clinical-neurology Why do systemic anti-inflammatory drugs
CHIP-mediated K63-linked ubiquitination promotes autophagoso 0.380 protein-biochemistry Do chaperones selectively recognize path
Closed-loop transcranial focused ultrasound with adaptive AP 0.380 - Survival Analysis of AD Patient Cohorts:
CRP-Mediated CCR2+ Monocyte Recruitment Drives Microglial IL 0.380 immunomics Systemic immune profiling in neurodegene
TREM2-Mediated Microglial Regulation of Oligodendrocyte Prec 0.380 connectomics Human connectome alterations in Alzheime
hs-CRP-Driven CCR2+ Monocyte Recruitment Disrupts CNS Immune 0.357 immunomics Systemic immune profiling in neurodegene
Glial Scar Architecture Manipulation for Functional Compartm 0.000 - Astrocyte Reactivity Subtypes in Neurode
APP Processing Compartmentalization Therapeutics 0.000 - Lipid raft composition changes in synapt

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
Microglial SIRPα expression in human Alzheimer's disease tissue exploratory Alzheimer's disease 0.800 0.00 human brain tissue proposed N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TME in their description or question text

TREM2-APOE Axis Manipulation via APOE Lipidation for DAM Recruitment

Score: 0.685 · neurodegeneration · 2026-04-25

Strongest mechanistic support among all hypotheses. TREM2-TYROBP signaling for DAM transition well-established. AL002 Ph

Retromer-dependent retrograde endosomal signaling compartmentalization as biomar

Score: 0.645 · neuroscience · 2026-04-26

VPS26/VPS29/VPS35 retromer complex maintains axonal endosomal signaling microdomains controlling TrkB/p75NTR trafficking

Colonic Th17/IL-17A Axis → Peripheral Immune Recruitment to SN and Neuronal Apop

Score: 0.640 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The gut-brain axis represents a critical bidirectional communication pathway link

HDAC3-Dependent A1 Astrocyte Commitment Window

Score: 0.611 · neurodegeneration · 2026-04-21

## Mechanistic Overview HDAC3-Dependent A1 Astrocyte Commitment Window starts from the claim that modulating HDAC3 withi

Multi-Biomarker Composite Index Surpassing Amyloid PET for Treatment Response Pr

Score: 0.579 · neurodegeneration · 2026-04-16

## Mechanistic Overview Multi-Biomarker Composite Index Surpassing Amyloid PET for Treatment Response Prediction starts

Dynamic Microglial Phenotype Switching Biomarker Panel for Neuroinflammatory Tre

Score: 0.577 · neurodegeneration · 2026-04-20

**Molecular Mechanism and Rationale** The molecular foundation of this biomarker panel centers on the intricate interpl

A genetically encoded reporter for axonal mitochondrial protein import fidelity

Score: 0.565 · neuroscience · 2026-04-26

MTS-dGFP fusion construct requires intact TOM40/TOM20 translocase for mitochondrial import, serving as direct read-out o

TFEB Activation Clears Tau-Loaded Endolysosomal Compartments, Preventing Release

Score: 0.560 · neurodegeneration · 2026-04-22

## Mechanistic Overview TFEB Activation Clears Tau-Loaded Endolysosomal Compartments, Preventing Release for Transcellul

Sticker-Spacer Phase Behavior Determines Recruitment Hierarchy

Score: 0.556 · molecular-biology · 2026-04-21

## Mechanistic Overview Sticker-Spacer Phase Behavior Determines Recruitment Hierarchy starts from the claim that modula

Optogenetic restoration of hippocampal gamma oscillations via channelrhodopsin-2

Score: 0.555 · alzheimers · 2026-04-21

## Mechanistic Overview Optogenetic restoration of hippocampal gamma oscillations via channelrhodopsin-2 expression in P

Charge-Pattern Asymmetry Creates Electrostatic Recruitment Gates

Score: 0.523 · molecular-biology · 2026-04-21

## Mechanistic Overview Charge-Pattern Asymmetry Creates Electrostatic Recruitment Gates starts from the claim that modu
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