concept

OXIDATIVE_STRESS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OXIDATIVE_STRESS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

73Connections

0Hypotheses

0Analyses

23Outgoing

31Incoming

Summary

OXIDATIVE_STRESS is a concept in neurodegeneration research. Key relationships include: causes, inhibits, activates. Associated with CVD, NEURODEGENERATION, PARKINSON_DISEASE. Connected to 46 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	OXIDATIVE_STRESS
Summary	Comprehensive mechanism page on oxidative stress in neurodegenerative diseases
Key Genes/Proteins	ASK1, Cytokines, TNF, NRF2, PI3K, AKT
Related Diseases	NEURODEGENERATION, STRESS_GRANULES, DNA_DAMAGE, FERROPTOSIS
Related Pathways	CA2_HOMEOSTASIS
Linked Hypotheses	1 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    OXIDATIVE_STRESS["OXIDATIVE_STRESS"]
    OXIDATIVE_STRESS -->|"activates"| NEURODEGENERATION["NEURODEGENERATION"]
    OXIDATIVE_STRESS -->|"causes"| hemolysis["hemolysis"]
    OXIDATIVE_STRESS -->|"causes"| OxPCs["OxPCs"]
    OXIDATIVE_STRESS -->|"inhibits"| CA2_HOMEOSTASIS["CA2_HOMEOSTASIS"]
    OXIDATIVE_STRESS -->|"causes"| STRESS_GRANULES["STRESS_GRANULES"]
    OXIDATIVE_STRESS -->|"causes"| DNA_DAMAGE["DNA_DAMAGE"]
    OXIDATIVE_STRESS -->|"causes"| FERROPTOSIS["FERROPTOSIS"]
    OXIDATIVE_STRESS -->|"regulates"| CA2["CA2"]
    OXIDATIVE_STRESS -->|"regulates"| calcium["calcium"]
    OXIDATIVE_STRESS -->|"causes"| intestinal_barrier["intestinal_barrier"]
    NRF2["NRF2"] -->|"regulates"| OXIDATIVE_STRESS
    HSPA1A["HSPA1A"] -->|"inhibits"| OXIDATIVE_STRESS
    hydrogen_peroxide["hydrogen_peroxide"] -->|"causes"| OXIDATIVE_STRESS
    ROS["ROS"] -->|"causes"| OXIDATIVE_STRESS
    SIRT1["SIRT1"] -->|"inhibits"| OXIDATIVE_STRESS
    SIRT3["SIRT3"] -->|"inhibits"| OXIDATIVE_STRESS
    METHYLENE_BLUE["METHYLENE_BLUE"] -->|"inhibits"| OXIDATIVE_STRESS
    curcumin["curcumin"] -->|"inhibits"| OXIDATIVE_STRESS
    GPS["GPS"] -->|"inhibits"| OXIDATIVE_STRESS

Outgoing (33)

Target	Relation	Type	Str
APOPTOSIS	associated_with	process	0.90
ASK1	activates	protein	0.90
NEURODEGENERATION	activates	disease	0.87
NEURON	causes	cell_type	0.80
CA2_HOMEOSTASIS	inhibits	pathway	0.72
STRESS_GRANULES	causes	phenotype	0.72
DNA_DAMAGE	causes	phenotype	0.72
FERROPTOSIS	causes	phenotype	0.72
CA2	regulates	protein	0.72
PARKINSON_DISEASE	contributes_to	disease	0.64
AUTOPHAGY	activates	pathway	0.64
DUBS	regulates	protein	0.64
NRF2	activates	gene	0.64
NEURODEGENERATION	causes	disease	0.64
TDP43	regulates	protein	0.64
PROTEIN_AGGREGATES	activates	phenotype	0.64
CVD	activates	disease	0.64
CELLULAR_SENESCENCE	activates	phenotype	0.64
GLUTATHIONYLATION	activates	phenotype	0.64
MITOXYPERIOSIS	causes	phenotype	0.64
CARDIAC_AGING	contributes_to	phenotype	0.64
OXPCS	produces	protein	0.56
AUTOPHAGY	inhibits	pathway	0.56

Incoming (40)

Source	Relation	Type	Str
Cytokines	causes	protein	0.90
TNF	associated_with	protein	0.85
NRF2	regulates	protein	0.79
Edaravone	treats	drug	0.78
PI3K	involved_in	gene	0.75
AKT	involved_in	gene	0.75
HSPA1A	inhibits	gene	0.72
SIRT1	inhibits	gene	0.72
SIRT3	inhibits	gene	0.72
METHYLENE_BLUE	inhibits	drug	0.64
NRF2	inhibits	protein	0.64
GPS	inhibits	drug	0.64
AUTOPHAGY	inhibits	pathway	0.64
MITOCHONDRIAL_DYSFUNCTION	causes	phenotype	0.64
UBQLN2	inhibits	gene	0.64
HSV1	causes	pathogen	0.64
HIV	causes	pathogen	0.64
INFLUENZA_VIRUS	causes	pathogen	0.64
CHLAMYDIA_PNEUMONIAE	causes	pathogen	0.64
INFLAMMATION	activates	phenotype	0.64
SIRT2	inhibits	gene	0.64
SIRT6	inhibits	gene	0.64
METFORMIN	regulates	drug	0.64
BAX	causes	gene	0.64
BAK1	causes	gene	0.64
BID	causes	gene	0.64
BPMC	activates	drug	0.64
T835M	causes	protein	0.64
SIRTUINS	regulates	protein	0.64
MITOCHONDRIA	contributes_to	cell_type	0.56
SOD1	regulates	gene	0.56

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

OXIDATIVE_STRESS

Understanding Entity Pages

Summary

Wiki Pages (21)