Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about METHYLATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| HPA Axis | regulates | pathway | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PROTEIN ARGININE METHYLTRANSFERASES | catalyzes | enzyme | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| p38α Inhibitor and PRMT1 Activator Combination to Restore Ph | 0.615 | neurodegeneration | What is the therapeutic window between i |
| TET2-Mediated Demethylation Rejuvenation Therapy | 0.469 | neurodegeneration | Epigenetic clocks and biological aging i |
| Arginine Methylation Enhancement Therapy | 0.463 | neurodegeneration | TDP-43 phase separation therapeutics for |
| Temporal TET2-Mediated Hydroxymethylation Cycling | 0.408 | neurodegeneration | Epigenetic reprogramming in aging neuron |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-12 | 2 hypotheses Top: 0.615
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.670
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Predicting the molecular mechanism of ginger targeting PRMT1/BTG2 axis to inhibi [PMID:40446574] | Chen G, Gou B, Du Y, Zhou Z, Bai Y, Yang | Phytomedicine | 2025 | 1 |
| PRMT1 promotes pancreatic cancer development and resistance to chemotherapy. [PMID:38460517] | Ku B, Eisenbarth D, Baek S, Jeong TK, Ka | Cell Rep Med | 2024 | 1 |
| PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemor [PMID:38383964] | Yamamoto T, Hayashida T, Masugi Y, Oshik | Cancer Res | 2024 | 1 |
| Promising role of protein arginine methyltransferases in overcoming anti-cancer [PMID:37980859] | Zhu Y, Xia T, Chen DQ, Xiong X, Shi L, Z | Drug Resist Updat | 2024 | 1 |
| Protein arginine methylation: from enigmatic functions to therapeutic targeting. [PMID:33742187] | Wu Q, Schapira M, Arrowsmith CH, Barsyte | Nat Rev Drug Discov | 2021 | 1 |
| SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans. [PMID:33398264] | Turner JS, Kim W, Kalaidina E, Goss CW, | Res Sq | 2020 | 1 |
| Reply to Rosen: Temperature-growth relationship is robust. [PMID:31375623] | Diffenbaugh NS, Burke M | Proc Natl Acad Sci U S A | 2019 | 1 |
| Cryo-electron microscopy structures of human oligosaccharyltransferase complexes [PMID:31831667] | Ramírez AS, Kowal J, Locher KP | Science | 2019 | 1 |
| The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663] | Krasemann S, Madore C, Cialic R, Baufeld | Immunity | 2017 | 1 |
| The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with [PMID:28068668] | Britschgi A, Duss S, Kim S, Couto JP, Br | Nature | 2017 | 1 |
| CD161 defines a transcriptional and functional phenotype across distinct human T [PMID:25437561] | Fergusson JR, Smith KE, Fleming VM, Rajo | Cell Rep | 2014 | 1 |
| Genome-wide methylation profiles reveal quantitative views of human aging rates. [PMID:23177740] | Hannum G, Guinney J, Zhao L, Zhang L, Hu | Mol Cell | 2013 | 1 |
| Repression of PRMT activities sensitize human homologous recombination-proficien [PMID:41632514] | ["Zhang Y", "Xu M", "Yuan J", "Hu Z", "J | eLife | 2026 | 0 |
| Ginsenoside RG3 and cantharidin synergistically suppress the progression of hepa [PMID:41501793] | ["Wang Y", "Yuan H", "Yu Y", "Gou X", "W | Journal of translational medic | 2026 | 0 |
| Protein arginine methyltransferases in cancer: mechanisms, functions, and therap [PMID:41928257] | Jeong Y, Cho Y, Kim YK | J Biomed Sci | 2026 | 0 |
| Targeting PRMTs Creates Vulnerability of DNA Double-Stand Break Repair Pathways, [PMID:41801765] | Thiebaut C, Martinez S, Pruvost L, Eve L | Cancer science | 2026 | 0 |
| Potentiating BSEP-mediated bile acid efflux reverses first-line tyrosine kinase [PMID:41903671] | Wu Z, Wang Y, Yu B, Yu R, Chen M, Chen Z | Cancer letters | 2026 | 0 |
| LC-MS profiling of [PMID:41756837] | ["Basirattalab A", "Wallis D", "Hartel N | bioRxiv : the preprint server | 2026 | 0 |
| Discovery of the First-in-Class Protein Arginine Methyltransferase 1 PROTAC Degr [PMID:41830641] | Guo S, Li J, Lin J, Chen Y, Liu C, Liu H | Journal of medicinal chemistry | 2026 | 0 |
| PRMT1 facilitates the tumorigenesis of chronic lymphocytic leukemia by regulatin [PMID:41912914] | Tian Z, Gao P, Zhang Y, Ma J, Hu X, Wang | Leukemia | 2026 | 0 |