Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MICROGLIAL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| SENESCENCE | undergoes | process | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| glucose metabolic reprogramming | occurs_in | process | 0.80 |
| PFKFB3 | drives | gene | 0.80 |
| PFKFB3 | expressed_in | gene | 0.80 |
| HV1 | expressed_in | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Anti-miR-155 LNA Oligonucleotide Shifts Microglia to Homeostatic State | in_vivo | neurodegeneration | 0.774 | 0.65 | C57BL/6J LPS model (chronic i. | proposed | $58,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 1 |
| Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861] | ["Han X", "Sun S", "Sun Y", "Song Q", "Z | Autophagy | 2020 | 1 |
| Targeting Microglial Phagocytosis for Alzheimer's Disease Management: Natural, P [PMID:40641018] | Raghuvanshi S, Mazumder A, Das S | CNS & neurological disorders d | 2026 | 0 |
| Changes in Circulating Levels of miR-30b During Minipuberty and Puberty in Girls [PMID:40899010] | Albrechtsen HM, Saritas G, Winge SB, Mai | J Clin Endocrinol Metab | 2026 | 0 |
| Epigenetics in chronic rhinosinusitis. [PMID:41442742] | Kumar N, Brar T, Lal D | Curr Opin Otolaryngol Head Nec | 2026 | 0 |
| Opioid-induced transcriptional reprogramming of cerebrospinal fluid immune cells [PMID:41674808] | Acharya A, Ambikan AT, Neogi U, Lamberty | Res Sq | 2026 | 0 |
| Siah2 is a lipid-mediated metabolic sensor in adipose tissue macrophage. [PMID:41690475] | Dang TN, Ghosh B, Panta PR, Taylor JM, K | J Lipid Res | 2026 | 0 |
| Extracellular vesicles in type 2 diabetes exhibit elevated miR-155 cargo and Ann [PMID:41786286] | Jackson G, Islam H, de Souza Teixeira AA | Life Sci | 2026 | 0 |
| Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207] | Mishra R, Gupta JK | Curr Alzheimer Res | 2026 | 0 |
| Di-2-ethylhexylphthalate-induced miR155-5P promotes placental ferroptosis. [PMID:41937013] | Gu X, Sun F, Li Y, Yang S, Li Y | Int J Biol Macromol | 2026 | 0 |
| Extracellular Vesicles in Obesity: From Pathophysiological Mediators to Therapeu [PMID:41977323] | Pavlović N, Todorović P, Maglica M, Kopi | Int J Mol Sci | 2026 | 0 |
| Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207] | Mishra R, Gupta JK | Current Alzheimer research | 2026 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| The APOE-Microglia Axis in Alzheimer's Disease: Functional Divergence and Therap [PMID:40722268] | Unknown | Brain sciences | 2025 | 0 |
| Emerging Molecular Targets in Neurodegenerative Disorders: New Avenues for Thera [PMID:40922457] | ["Eroglu E", "Harmanci N"] | Basic & clinical pharmacology | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Soluble CSF1R promotes microglial activation and amyloid clearance in alzheimer' [PMID:41152873] | Zhang L, Chen K, Zeng R | J Neuroinflammation | 2025 | 0 |
| Apolipoprotein E dysfunction in Alzheimer's disease: a study on miRNA regulation [PMID:39744521] | ["Wijesinghe Printha", "Li Hao Ran", "Ai | Frontiers in aging neuroscienc | 2024 | 0 |
| Trem2-deficiency aggravates and accelerates age-related myelin degeneration. [PMID:39300502] | ["McCray Tyler J", "Bedford Logan M", "B | Acta neuropathologica communic | 2024 | 0 |
| Inhibition of autophagy in microglia and macrophages exacerbates innate immune r [PMID:36652438] | Hegdekar N, Sarkar C, Bustos S, Ritzel R | Autophagy | 2023 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MICROGLIAL in their description or question text
Score: 0.837 · neurodegeneration · 2026-04-17
## Mechanistic Overview Microglial Senescence Prevention via TREM2/SASP Axis starts from the claim that modulating not y
Score: 0.836 · neurodegeneration · 2026-04-22
## Mechanistic Overview TREM2 Deficiency Drives Microglial Senescence via Lipid Metabolism Dysregulation starts from the
Score: 0.827 · neuroscience · 2026-04-07
## Mechanistic Overview Microglial-Mediated Tau Clearance Dysfunction via TREM2 Signaling starts from the claim that mod
Score: 0.824 · neurodegeneration · 2026-04-05
## Mechanistic Overview Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 Proteinopathy Neuroinflammation in
Score: 0.808 · neurodegeneration · 2026-04-16
## Mechanistic Overview CSF1R-TREM2 Co-Agonism for Sustained Microglial Expansion starts from the claim that modulating
Score: 0.805 · neurodegeneration · 2026-04-02
## Mechanistic Overview Targeted Butyrate Supplementation for Microglial Phenotype Modulation starts from the claim that
Score: 0.804 · multi · 2026-04-28
Shared mechanism across AD, ALS, PD: TREM2-APOE signaling shifts microglia into a disease-associated state that can clea
Score: 0.798 · neurodegeneration · 2026-04-13
## Mechanistic Overview Microglial TREM2-SYK Pathway Enhancement starts from the claim that modulating TREM2 within the
Score: 0.780 · neurodegeneration · 2026-04-16
## Mechanistic Overview TREM2-mediated microglial tau clearance enhancement starts from the claim that modulating TREM2
Score: 0.771 · neuroscience · 2026-04-22
**Molecular Mechanism and Rationale** The triggering receptor expressed on myeloid cells 2 (TREM2) represents a critica
Score: 0.768 · drug-delivery · 2026-04-22
**Molecular Mechanism and Rationale** The AAV-PHP.eB-mediated delivery of IGFBPL1 to microglia exploits a sophisticated
Score: 0.761 · neuroscience · 2026-04-28
GluN2B signaling in cortical excitatory neurons releases fractalkine (CX3CL1) via activity-dependent TACE/ADAM17 sheddin
Score: 0.758 · neurodegeneration · 2026-04-16
## Mechanistic Overview INPP5D (SHIP1) Inhibition to Shift Microglial Polarization starts from the claim that modulating
Score: 0.748 · neurodegeneration · 2026-04-12
**Molecular Mechanism and Rationale** The TREM2-CSF1R metabolic cross-talk hypothesis centers on the intricate molecula
Score: 0.744 · neurodegeneration · 2026-04-12
**Molecular Mechanism and Rationale** The TREM2-SIRT1 metabolic senescence circuit represents a critical regulatory net