entity

MICROGLIAL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MICROGLIAL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

30Hypotheses

30Analyses

1Outgoing

4Incoming

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Outgoing (1)

Target	Relation	Type	Str
SENESCENCE	undergoes	process	0.80

Incoming (5)

Source	Relation	Type	Str
glucose metabolic reprogramming	occurs_in	process	0.80
PFKFB3	drives	gene	0.80
PFKFB3	expressed_in	gene	0.80
HV1	expressed_in	gene	0.80

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2-Dependent Microglial Senescence Transition	0.692	neurodegeneration	Gene expression changes in aging mouse b
SASP-Driven Microglial Metabolic Reprogramming in Synaptic P	0.638	neurodegeneration	Senolytic therapy for age-related neurod
Microglial TREM2-SYK Pathway Enhancement	0.626	neurodegeneration	Cell type vulnerability in Alzheimers Di
TREM2-ASM Crosstalk in Microglial Lysosomal Senescence	0.612	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Microglial Clearance Enhancement as Common Mechanism f	0.604	neurodegeneration	Why do p300/CBP inhibitors reduce both A

Microglial AIM2 Inflammasome as the Primary Driver of TDP-43	0.601	neurodegeneration	What are the mechanisms by which gut mic
SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senesc	0.600	neurodegeneration	Gene expression changes in aging mouse b
C3aR Blockade Disrupts the Microglial-Astrocyte Feedforward	0.596	neuroinflammation	What molecular mechanisms determine whet
TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming	0.589	neurodegeneration	Gene expression changes in aging mouse b
TREM2-SIRT1 Metabolic Senescence Circuit in Microglial Aging	0.587	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Mediated Cholesterol Dysregulation in Microglial Senes	0.574	neurodegeneration	Gene expression changes in aging mouse b
CYP46A1 Gene Therapy for Age-Related TREM2-Mediated Microgli	0.569	neurodegeneration	Lipid raft composition changes in synapt
Targeted Butyrate Supplementation for Microglial Phenotype M	0.559	neurodegeneration	What are the mechanisms by which gut mic
ABCA7-TREM2 Co-Targeting for Microglial Lipid Handling	0.538	neurodegeneration	Why does the V1613M variant reduce amylo
Microglial-Mediated Tau Clearance Dysfunction via TREM2 Sign	0.533	neuroscience	Circuit-level neural dynamics in neurode
TREM2-Mediated Microglial Dysfunction Disrupts Perivascular	0.527	neuroscience	Circuit-level neural dynamics in neurode
Microglial TREM2-Complement Axis Modulation	0.527	neurodegeneration	Cell type vulnerability in Alzheimer's D
Epigenetic Reprogramming of Microglial Memory	0.508	Alzheimer's disease	Neuroinflammation and microglial priming
Microglial TREM2 downregulation impairs damage-associated re	0.507	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
APOE4-Specific Microglial Metabolic Rescue	0.498	-	Neuroinflammation and microglial priming
Microglial-Mediated Tau Clearance Dysfunction via TREM2 Rece	0.489	neuroscience	Circuit-level neural dynamics in neurode
TREM2-mediated microglial tau clearance enhancement	0.487	Alzheimer's Disease	Tau propagation mechanisms and therapeut
Microglial Purinergic Reprogramming	0.483	neurodegeneration	4R-tau strain-specific spreading pattern
Microglial Efferocytosis Enhancement via GPR32 Superagonists	0.483	neurodegeneration	Neuroinflammation resolution mechanisms
Microglial Exosome-Mediated Tau Propagation	0.468	neuroscience	Circuit-level neural dynamics in neurode
Circadian-Metabolic Microglial Reprogramming	0.462	-	Neuroinflammation and microglial priming
DAMP-Scavenging Microglial Reset	0.462	-	Neuroinflammation and microglial priming
Astrocyte-Mediated Microglial Memory Erasure	0.462	-	Neuroinflammation and microglial priming
Temporal Microglial State Switching	0.462	-	Neuroinflammation and microglial priming
TREM2-Mediated Microglial Checkpoint Therapy	0.462	neurodegeneration	Cell type vulnerability in Alzheimer's D

Mentioning Analyses (30)

Scientific analyses that reference this entity

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

neuroinflammation | 2026-04-15 | 1 hypotheses Top: 0.650

What is the temporal sequence of TREM2 signaling transition from protective to i

neuroimmunology | 2026-04-15 | 2 hypotheses Top: 0.674

What molecular mechanisms enable Gal3 to enhance tau fibrillation upon binding t

neurodegeneration | 2026-04-15 | 0 hypotheses

What are the molecular signatures that distinguish protective vs. harmful microg

neurodegeneration | 2026-04-12 | 0 hypotheses

Do P2RX7 antagonists selectively block pathogenic exosomes while preserving bene

neurodegeneration | 2026-04-11 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214]	Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia	J Inflamm Res	2022	1
TREM2, microglia, and Alzheimer's disease. [PMID:33516818]	Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang	Mech Ageing Dev	2021	1
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797]	Zhou Y, Song WM, Andhey PS, Swain A, Lev	Nat Med	2020	1
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. [PMID:28802038]	Ulland TK, Song WM, Huang SC, Ulrich JD,	Cell	2017	1
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663]	Krasemann S, Madore C, Cialic R, Baufeld	Immunity	2017	1
Precision Neurodegeneration: Integrating Molecular Mechanisms, Biomarkers, and T [PMID:41833042]	["Lyu G", "Li D"]	CNS & neurological disorders d	2026	0
Emerging pathological mechanisms of Alzheimer's disease pathogenesis: from neuro [PMID:41858793]	["Wang R", "Feng Y", "Zhou Z", "Jiang J"	Frontiers in aging neuroscienc	2026	0
Human CSF proteogenomics links genetic variation to neurodegenerative disease pr [PMID:41757182]	["Puerta R", "Garc\u00eda-Gonz\u00e1lez	medRxiv : the preprint server	2026	0
PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907]	Tsai AP, Martin AK, Mi A, Yeh AE, Ramire	Molecular neurodegeneration	2026	0
TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604]	Yang HC, Deng YS, Zhang J, Zhang T, Song	J Alzheimers Dis	2026	0
A scalable human-zebrafish xenotransplantation model reveals gastrosome-mediated [PMID:41957412]	Villani A, Wittmann J, Wyss T, Mallona I	Commun Biol	2026	0
Dual Role of Microglial TREM2 in Neuronal Degeneration and Regeneration After Ax [PMID:41963086]	Pottorf TS, Lane EL, Haley-Johnson Z, Uk	J Neurosci	2026	0
TREM2-mediated microglial phagocytosis of inhibitory synapses contributes to pro [PMID:41965330]	Wang X, Zhou H, Zhai Y, Zhang Y, Cheng Y	Cell Death Discov	2026	0
Investigating the Potential of Gene Editing Technologies in Enhancing Stem Cell [PMID:41926312]	["Mehrabadi S"]	Current aging science	2026	0
TREM2 in neurodegeneration and diseases. [PMID:41792456]	["Abdulkhaliq A", "Alasiri G", "Kim B",	Molecular psychiatry	2026	0
Berbamine hydrochloride as a brain penetrant galectin 3 inhibitor in a model of [PMID:41772384]	["Siew J", "Lee C", "Chen H", "Lin H", "	Brain : a journal of neurology	2026	0
The microglial TREM2 receptor programs hippocampal development in a mouse model [PMID:41887542]	Ahmed S, Bowers C, Munoz-Martin J, Jamwa	Brain, behavior, and immunity	2026	0
Molecular mechanism of Alzheimer's disease using integrated multi-omics. [PMID:41907842]	Alhusaini M, Mussa BM, Ilce BY, Alhaj H,	Frontiers in aging neuroscienc	2026	0
Oligodendrocyte precursor cells-microglia crosstalk via BMP4 drives microglial n [PMID:41881962]	Baek S, Jang J, Yeo S, Jung HJ, Choe Y	Signal transduction and target	2026	0
Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ4 [PMID:41770935]	["Konstantoulea K", "Ramakers M", "Borri	Proceedings of the National Ac	2026	0

MICROGLIAL

Understanding Entity Pages

Wiki Pages (21)

AD Microglial Phagocytosis and Synaptic Pruning Companies

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alpha-Synuclein Pathology

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

PD Combination Therapy Matrix

Alzheimer's Disease Mechanism Index

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

nimodipine-als

Neuroresilience Mechanisms and Evidence

Outgoing (1)

Incoming (5)

Targeting Hypotheses (30)

Mentioning Analyses (30)

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

What is the temporal sequence of TREM2 signaling transition from protective to i

What molecular mechanisms enable Gal3 to enhance tau fibrillation upon binding t

What are the molecular signatures that distinguish protective vs. harmful microg

Do P2RX7 antagonists selectively block pathogenic exosomes while preserving bene

What brain concentrations of SCFAs are achieved via oral probiotics and are they

Can circadian interventions selectively target microglia without affecting other

Which specific metabolic pathways in APOE4+ microglia are most therapeutically t

Why does prolonged anesthesia cause both cognitive dysfunction and anxiety throu

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

Do different priming stimuli require distinct therapeutic approaches or share co

Can circadian interventions reverse microglial priming independent of sleep disr

How can CNS-selective HDAC/DNMT inhibitors be developed to avoid systemic toxici

What specific astrocyte-derived factors can 'erase' pathological microglial memo

How does sevoflurane-induced NF-κB activation specifically trigger complement ca

What determines the selectivity of complement-mediated synaptic elimination in p

What causes IBA1 low/negative microglia in liver disease and how does this affec

What is the optimal therapeutic window during preclinical AD for epigenetic repr

Do microglia actually switch between glycolytic and oxidative phosphorylation as

Does SPP1-mediated synaptic engulfment represent beneficial clearance or patholo

How do perivascular cells specifically recognize and respond to amyloid-β to upr

What molecular mechanisms drive microglial senescence and the transition to dyst

What biomarkers can reliably detect microglial priming states in living patients

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

How can senescent microglia be molecularly distinguished from beneficial activat

Can IGFBPL1 therapeutics effectively cross the blood-brain barrier to reach CNS

How do regional, age, and sex-dependent differences in microglial populations af

Neuroinflammation and microglial priming in early AD

Neuroinflammation and microglial priming in early Alzheimer's Disease

Neuroinflammation and microglial priming in early Alzheimer's Disease

Related Papers (20)