protein

PFKFB3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PFKFB3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

224Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

Page for PFKFB3 Protein

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🔬 Protein Info

Gene Symbol	PFKFB3
Function	PFKFB3 Protein is a protein involved in various cellular processes.
Subcellular Localization	signal (NLS) and can translocate to the nucleus, where it may regulate glycolyti
Molecular Weight	58 kDa
Pathways	Aerobic Glycolysis
GeneCards	PFKFB3
Human Protein Atlas	PFKFB3
Associated Diseases	ALS, Cancer, Inflammation, Multiple Sclerosis, Neurodegeneration
Known Drugs/Compounds	Bergenin
Interactions	GLUT1, MAPK, ERK, HIF, CANCER, AKT
KG Connections	224 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (10)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PFKFB3["<b>PFKFB3</b>"]
    Microglial_Glycolytic_Reprogramming(["Microglial Glycolytic Reprogramming"])
    PFKFB3 -->|"activates"| Microglial_Glycolytic_Reprogramming
    Neuroinflammation(["Neuroinflammation"])
    PFKFB3 -->|"mediates"| Neuroinflammation
    Microglia["Microglia"]
    PFKFB3 -->|"expressed in"| Microglia
    Aerobic_Glycolysis(["Aerobic Glycolysis"])
    PFKFB3 -->|"involved in"| Aerobic_Glycolysis
    Bergenin["Bergenin"]
    Bergenin -->|"binds"| PFKFB3
    Bergenin -->|"inhibits"| PFKFB3
    style PFKFB3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (152)

Target	Relation	Type	Str
Traumatic Brain Injury	drives	disease	0.95
Aerobic Glycolysis	involved_in	process	0.80
MICROGLIAL	drives	cell_type	0.80
glycolytic-inflammatory crosstalk	drives	process	0.80
MICROGLIAL	expressed_in	cell_type	0.80
GLYCOLYSIS	drives	process	0.80
PKM2	activates	gene	0.70
Metabolic Syndrome	activates	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	activates	disease	0.65
Ms	regulates	disease	0.65
Traumatic Brain Injury	inhibits	disease	0.65
Als	inhibits	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Aging	regulates	disease	0.65
ALS	inhibits	disease	0.65
Neurodegeneration	causes	disease	0.65
Multiple Sclerosis	causes	disease	0.65
Inflammation	causes	disease	0.65
Aging	methylates	disease	0.65
Cancer	methylates	disease	0.65
Neurodegeneration	degrades	disease	0.65
Multiple Sclerosis	degrades	disease	0.65
Cancer	associated_with	disease	0.65
MICROGLIAL ACTIVATION	inhibits	phenotype	0.65
MICROGLIA	targets	cell_type	0.65
NEURON	causes	cell_type	0.65
GLUT1	activates	gene	0.60
MAPK	activates	gene	0.60
ERK	activates	gene	0.60
HIF	activates	gene	0.60
CANCER	activates	gene	0.60
AKT	activates	gene	0.60
KRAS	activates	gene	0.60
MTOR	activates	gene	0.60
Tgf-Β	activates	pathway	0.60
Mapk	activates	pathway	0.60
Glycolysis	activates	pathway	0.60
Akt	activates	pathway	0.60
Mtor	activates	pathway	0.60
Pi3K	activates	pathway	0.60
IFN	activates	gene	0.60
TNF	inhibits	gene	0.60
BRAIN INJURY	inhibits	gene	0.60
SPR	interacts_with	gene	0.60
IL-6	inhibits	gene	0.60
IFN-Γ	activates	gene	0.60
AND	activates	gene	0.60
LDHA	inhibits	gene	0.60

Incoming (72)

Source	Relation	Type	Str
PRMT1	associated_with	protein	0.95
PRMT1	phosphorylates	entity	0.90
Bergenin	interacts_with	compound	0.90
Pi3K/Akt Pathway	phosphorylates	pathway	0.90
PI3K/AKT	phosphorylates	pathway	0.90
h-2a1a95c1	targets_gene	hypothesis	0.90
h-var-ac50d1e3d1	targets_gene	hypothesis	0.90
HIF1A	upregulates	gene	0.88
AKT1	phosphorylates	protein	0.85
MICROGLIA	upregulates	cell_type	0.80
PAL	upregulates	compound	0.80
CHEMORESISTANCE	modifies	phenotype	0.65
NEURON	targets	cell_type	0.65
LDHA	expressed_in	gene	0.60
PI3K	activates	gene	0.60
AND	expressed_in	gene	0.60
MYC	activates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
GENES	inhibits	gene	0.60
PRMT1	therapeutic_target	gene	0.60
PHGDH	therapeutic_target	gene	0.60
SPR	interacts_with	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
PKM2	methylates	gene	0.60
FASN	methylates	gene	0.60
PRMT1	methylates	gene	0.60
PKM2	inhibits	gene	0.60
HV1	inhibits	gene	0.60
HIF1	inhibits	gene	0.60
MICROGLIA	regulates	gene	0.60
RNA	regulates	gene	0.60
PSMB8	therapeutic_target	gene	0.60
FASN	activates	gene	0.60
PKM2	therapeutic_target	gene	0.60
IL-1	inhibits	gene	0.60
HK2	inhibits	gene	0.60
LDHA	inhibits	gene	0.60
MS4A4A	associated_with	gene	0.60
CCR8	associated_with	gene	0.60
LAG3	associated_with	gene	0.60
COMPLEMENT	associated_with	gene	0.60
TGFB1	associated_with	gene	0.60
FOXP3	associated_with	gene	0.60
KRAS	associated_with	gene	0.60
HEDGEHOG	associated_with	gene	0.60
NOTCH	associated_with	gene	0.60
CD163	associated_with	gene	0.60
STAT5B	associated_with	gene	0.60
HK2	activates	gene	0.60
LDHA	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Which cell types show the most significant expression changes for neurodegenerat

neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.529

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PFKFB3

Understanding Entity Pages

Summary

Wiki Pages (10)

TBX2 — T-Box Transcription Factor 2

Microglial Phagocytosis in Neurodegeneration

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TIGAR - TP53-Induced Glycolysis and Apoptosis Regulator

Microglial Metabolic Reprogramming

STAT5B Gene

TIGAR Protein — TP53-Induced Glycolysis and Apoptosis Regulator

SIRT6 Protein

PFKFB3 Protein