biological_process

SENESCENCE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SENESCENCE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2624Connections

11Hypotheses

9Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🧬 Biological Process Info

Name	SENESCENCE
Category	cellular senescence, aging, Alzheimer's, Parkinson's
Summary	Cross-disease comparison of cellular senescence mechanisms in Alzheimer's, Parkinson's, ALS, FTD, and Huntington's disease
Key Genes/Proteins	AQP4
Related Diseases	Ph-Like ALL
Linked Hypotheses	11 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SENESCENCE["SENESCENCE"] -->|"contributes to"| TUMOR["TUMOR"]
    SENESCENCE["SENESCENCE"] -->|"causes"| STING["STING"]
    SENESCENCE["SENESCENCE"] -->|"expressed in"| T_CELL["T CELL"]
    SENESCENCE["SENESCENCE"] -->|"expressed in"| T_CELLS["T CELLS"]
    SENESCENCE["SENESCENCE"] -->|"associated"| T_CELL_1["T CELL"]
    SENESCENCE["SENESCENCE"] -->|"associated"| T_CELLS_2["T CELLS"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated"| SENESCENCE["SENESCENCE"]
    NEURODEGENERATION["NEURODEGENERATION"] -->|"associated"| SENESCENCE["SENESCENCE"]
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"associated"| SENESCENCE["SENESCENCE"]
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"associated"| SENESCENCE["SENESCENCE"]
    style SENESCENCE fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (607)

Target	Relation	Type	Str
NEUROINFLAMMATION	associated_with	entity	0.90
Ph-Like ALL	associated_with	disease	0.85
ALZHEIMER'S DISEASE	contributes_to	entity	0.75
PARKINSON'S DISEASE	contributes_to	entity	0.75
AGE-RELATED NEUROPATHY	contributes_to	entity	0.75
GLIOMA	modulates	entity	0.75
AGING	interacts_with	process	0.72
NEURODEGENERATION	implicated_in	process	0.72
AGING	implicated_in	process	0.72
AGING	regulates	process	0.72
AQP4	stabilizes	gene	0.70
LIPID PEROXIDATION	regulates	phenotype	0.70
DNA DAMAGE RESPONSE	causes	pathway	0.70
PHAGOCYTOSIS	inhibits	phenotype	0.70
EGFR	activates	gene	0.70
STING	mediated_by	gene	0.65
COGNITIVE DECLINE	causes	phenotype	0.65
FIBROSIS	targets	disease	0.65
ANGIOGENESIS	inhibits	phenotype	0.65
RIBOSOME	activates	organelle	0.65
MMP2	inhibits	gene	0.65
TAU	produces	protein	0.65
COGNITIVE DECLINE	interacts_with	phenotype	0.65
NEURODEGENERATION	increases_risk	disease	0.65
CYTOKINES	produces	phenotype	0.65
INFLAMMATION	causes	phenotype	0.65
MITOCHONDRIAL DYSFUNCTION	protects_against	phenotype	0.65
ABCA1	regulates	gene	0.65
STROKE	targets	disease	0.65
HIPPOCAMPUS	inhibits	brain_region	0.65
INFLAMMATION	exacerbates	phenotype	0.65
INFLAMMATION	degrades	phenotype	0.65
NEUROGENESIS	causes	phenotype	0.65
NEUROGENESIS	treats	phenotype	0.65
RIBOSOME	destabilizes	organelle	0.60
LIPID PEROXIDATION	activates	phenotype	0.60
LIPID PEROXIDATION	synergizes_with	phenotype	0.60
AGING	causes	process	0.58
MITOCHONDRIAL DYSFUNCTION	activates	process	0.58
WOUND HEALING	implicated_in	phenotype	0.55
MICROGLIA	expressed_in	cell_type	0.55
COGNITIVE DECLINE	implicated_in	phenotype	0.55
ABCA1	expressed_in	gene	0.55
AGING	participates_in	phenotype	0.55
STING	co_discussed	entity	0.50
T CELL	co_discussed	entity	0.50
T CELLS	co_discussed	entity	0.50
STING SIGNALING	regulates	process	0.50
STEM CELLS	activates	cell_type	0.50
STEM CELLS	associated_with	cell_type	0.50

Incoming (2017)

Source	Relation	Type	Str
mitochondrial dysfunction	induces	process	0.90
STRESS GRANULES	interacts_with	entity	0.80
SASP	associated_with	entity	0.80
MICROGLIAL	undergoes	cell_type	0.80
MICROGLIA	treats	cell_type	0.70
CGAS	protects_against	gene	0.70
GPX4	protects_against	gene	0.70
GPX4	activates	gene	0.70
GPX4	stabilizes	gene	0.70
OLIGODENDROCYTE	treats	cell_type	0.70
SIRT6	exacerbates	gene	0.70
SIRT6	protects_against	gene	0.70
TERT	protects_against	gene	0.70
TREM2	inhibits	gene	0.70
ENDOTHELIAL CELLS	regulates	cell_type	0.65
CELL CYCLE	interacts_with	process	0.65
NEUROINFLAMMATION	mediated_by	process	0.65
AUTOPHAGY	exacerbates	phenotype	0.65
AUTOPHAGY	treats	phenotype	0.65
MAPK PATHWAY	causes	pathway	0.65
MAPK PATHWAY	activates	pathway	0.65
SMAD3	regulates	gene	0.65
STING PATHWAY	treats	pathway	0.65
SMAD SIGNALING	regulates	pathway	0.65
TSC2	converts	gene	0.65
TUMOR CELLS	activates	cell_type	0.65
QUERCETIN	treats	drug	0.65
QUERCETIN	activates	drug	0.65
HYDROXYCHLOROQUINE	protects_against	drug	0.65
ATG5	activates	gene	0.65
RAPAMYCIN	inhibits	drug	0.65
PROTEIN AGGREGATION	interacts_with	phenotype	0.65
QUERCETIN	inhibits	drug	0.65
STING	interacts_with	gene	0.65
MLKL	causes	gene	0.65
TAU	activates	protein	0.65
CURCUMIN	regulates	drug	0.65
SPERMIDINE	treats	drug	0.65
IL1B	interacts_with	gene	0.65
MITOCHONDRIAL DYSFUNCTION	treats	phenotype	0.65
NLRP3	treats	gene	0.65
MICROGLIAL ACTIVATION	inhibits	phenotype	0.65
TFEB	protects_against	gene	0.65
NEURODEGENERATION	biomarker_for	disease	0.65
CURCUMIN	protects_against	drug	0.65
LITHIUM	inhibits	drug	0.65
GLIOBLASTOMA	activates	disease	0.65
OLIGODENDROCYTES	causes	cell_type	0.65
ABCA1	treats	gene	0.65
IL1B	targets	gene	0.65

Targeting Hypotheses (11)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2-Dependent Microglial Senescence Transition	0.692	neurodegeneration	Gene expression changes in aging mouse b
TREM2-ASM Crosstalk in Microglial Lysosomal Senescence	0.612	neurodegeneration	Gene expression changes in aging mouse b
Senescence-Activated NAD+ Depletion Rescue	0.604	neurodegeneration	Senolytic therapy for age-related neurod
SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senesc	0.600	neurodegeneration	Gene expression changes in aging mouse b
TREM2-SIRT1 Metabolic Senescence Circuit in Microglial Aging	0.587	neurodegeneration	Gene expression changes in aging mouse b

TREM2-Mediated Cholesterol Dysregulation in Microglial Senes	0.574	neurodegeneration	Gene expression changes in aging mouse b
CYP46A1 Gene Therapy for Age-Related TREM2-Mediated Microgli	0.569	neurodegeneration	Lipid raft composition changes in synapt
Senescence-Induced Lipid Peroxidation Spreading	0.533	neurodegeneration	Senolytic therapy for age-related neurod
Senescence-Associated Myelin Lipid Remodeling	0.511	neurodegeneration	Senolytic therapy for age-related neurod
cGAS-STING Senescence Circuit Disruption	0.486	neurodegeneration	Gene expression changes in aging mouse b
Senescence-Tau Decoupling Therapy	0.410	neurodegeneration	Gene expression changes in aging mouse b

Mentioning Analyses (9)

Scientific analyses that reference this entity

What is the temporal sequence of TREM2 signaling transition from protective to i

neuroimmunology | 2026-04-15 | 2 hypotheses Top: 0.674

How does engineered C. butyricum cross the blood-brain barrier to directly bind

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.675

How does pericyte senescence mechanistically promote glioma cell growth and inva

neurodegeneration | 2026-04-14 | 0 hypotheses

What distinguishes truly senescent brain cells from merely dysfunctional reactiv

cellular senescence | 2026-04-11 | 0 hypotheses

Can metabolic interventions truly reverse established cellular senescence or onl

cell biology | 2026-04-08 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Klebsiella pneumoniae Induces Ferroptosis and Lactation Dysfunction in Bovine Ma [PMID:40937759]	Mao P, Wang Z, Duan J, Dong P, Yuan C, L	J Agric Food Chem	2025	1
Targeting ferroptosis: novel therapeutic approaches and intervention strategies [PMID:41425591]	Luo Y, Long M, Wu X, Zeng L	Front Immunol	2025	1
Trimetazidine attenuates Ischemia/Reperfusion-Induced myocardial ferroptosis by [PMID:39134283]	Tan M, Yin Y, Chen W, Zhang J, Jin Y, Zh	Biochem Pharmacol	2024	1
Copy number deletion of PLA2G4A affects the susceptibility and clinical phenotyp [PMID:38816399]	Gao Z, Guo X, Sun Z, Wu S, Wang Q, Huang	Schizophrenia (Heidelb)	2024	1
Channeling Nicotinamide Phosphoribosyltransferase (NAMPT) to Address Life and De [PMID:38580317]	Velma GR, Krider IS, Alves ETM, Courey J	J Med Chem	2024	1
Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214]	Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia	J Inflamm Res	2022	1
TREM2, microglia, and Alzheimer's disease. [PMID:33516818]	Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang	Mech Ageing Dev	2021	1
NAD(+) metabolism, stemness, the immune response, and cancer. [PMID:33384409]	Navas LE, Carnero A	Signal Transduct Target Ther	2021	1
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797]	Zhou Y, Song WM, Andhey PS, Swain A, Lev	Nat Med	2020	1
NAD metabolism fuels human and mouse intestinal inflammation. [PMID:28877980]	Gerner RR, Klepsch V, Macheiner S, Arnha	Gut	2018	1
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. [PMID:28802038]	Ulland TK, Song WM, Huang SC, Ulrich JD,	Cell	2017	1
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663]	Krasemann S, Madore C, Cialic R, Baufeld	Immunity	2017	1
NAD+ and sirtuins in aging and disease. [PMID:24786309]	Imai S, Guarente L	Trends Cell Biol	2014	1
Lipoprotein-associated and secreted phospholipases A₂ in cardiovascular disease: [PMID:21098459]	Mallat Z, Lambeau G, Tedgui A	Circulation	2010	1
Phospholipase A2 regulation of bovine endometrial (BEND) cell prostaglandin prod [PMID:18811942]	Godkin JD, Roberts MP, Elgayyar M, Guan	Reprod Biol Endocrinol	2008	1
Precision Neurodegeneration: Integrating Molecular Mechanisms, Biomarkers, and T [PMID:41833042]	["Lyu G", "Li D"]	CNS & neurological disorders d	2026	0
Emerging pathological mechanisms of Alzheimer's disease pathogenesis: from neuro [PMID:41858793]	["Wang R", "Feng Y", "Zhou Z", "Jiang J"	Frontiers in aging neuroscienc	2026	0
Human CSF proteogenomics links genetic variation to neurodegenerative disease pr [PMID:41757182]	["Puerta R", "Garc\u00eda-Gonz\u00e1lez	medRxiv : the preprint server	2026	0
PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907]	Tsai AP, Martin AK, Mi A, Yeh AE, Ramire	Molecular neurodegeneration	2026	0
TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604]	Yang HC, Deng YS, Zhang J, Zhang T, Song	J Alzheimers Dis	2026	0

SENESCENCE

Understanding Entity Pages

Wiki Pages (21)

Cellular Senescence Disease Comparison

cbs-psp-daily-action-plan

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Parkinson's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Pathway Diagram

Outgoing (607)

Incoming (2017)

Targeting Hypotheses (11)

Mentioning Analyses (9)

What is the temporal sequence of TREM2 signaling transition from protective to i

How does engineered C. butyricum cross the blood-brain barrier to directly bind

How does pericyte senescence mechanistically promote glioma cell growth and inva

What distinguishes truly senescent brain cells from merely dysfunctional reactiv

Can metabolic interventions truly reverse established cellular senescence or onl

What is the optimal therapeutic window timing for autophagy enhancement versus s

Do APOE4-driven senescent astrocytes cause neurodegeneration or represent a prot

How can senescent microglia be molecularly distinguished from beneficial activat

Senescent cell clearance as neurodegeneration therapy

Related Papers (20)

SENESCENCE

Understanding Entity Pages

Wiki Pages (21)

Cellular Senescence Disease Comparison

cbs-psp-daily-action-plan

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Parkinson's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Device Therapies Comparison for CBS/PSP

Alzheimer's Disease Mechanism Index

Corticobasal Degeneration (CBD)

Therapeutics

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

Microglial Cells — Cell Type Hierarchy

coq10-neurodegeneration

TREM2 Mechanism Hub

Mitochondrial Quality Control

Astrocyte Reactivity Mechanism

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Autophagy Mechanisms

Oligodendrocytes

APOC4 — Apolipoprotein C-IV

Pathway Diagram

Outgoing (607)

Incoming (2017)

Targeting Hypotheses (11)

Mentioning Analyses (9)

What is the temporal sequence of TREM2 signaling transition from protective to i

How does engineered C. butyricum cross the blood-brain barrier to directly bind

How does pericyte senescence mechanistically promote glioma cell growth and inva

What distinguishes truly senescent brain cells from merely dysfunctional reactiv

Can metabolic interventions truly reverse established cellular senescence or onl

What is the optimal therapeutic window timing for autophagy enhancement versus s

Do APOE4-driven senescent astrocytes cause neurodegeneration or represent a prot

How can senescent microglia be molecularly distinguished from beneficial activat

Senescent cell clearance as neurodegeneration therapy

Related Papers (20)