Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Multiple: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | associated_with | disease | 0.50 |
| TREM2 | co_associated_with | gene | 0.40 |
| TNF/IL6 | co_associated_with | gene | 0.40 |
| Multiple | co_associated_with | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ent-gene-5b8aa21c | has_risk_variant | gene | 0.00 |
| ent-gene-0c093647 | has_risk_variant | gene | 0.00 |
| ent-gene-961a77ee | has_risk_variant | gene | 0.00 |
| APOE | co_associated_with | gene | 0.40 |
| IGFBPL1 | co_associated_with | gene | 0.40 |
| C1QA | co_associated_with | gene | 0.40 |
| Multiple | co_associated_with | gene | 0.40 |
| h-6f21f62a | targets | hypothesis | 0.30 |
| h-8f9633d9 | targets | hypothesis | 0.20 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
cellular senescence | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.735
neurodegeneration | 2026-04-04 | 20 hypotheses Top: 0.651
neurodegeneration | 2026-04-01 | 12 hypotheses Top: 0.777
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Single-cell RNA sequencing of EMT states in SCC | exploratory | Skin squamous cell carcinoma | 0.900 | 0.00 | Primary mouse model | proposed | N/A |
| Gene expression analysis of autophagy targets following trehalose trea | exploratory | motoneuron degeneration | 0.850 | 0.00 | neuronal cell lines | proposed | N/A |
| Trehalose-induced autophagy gene expression analysis | exploratory | motoneuron degeneration | 0.850 | 0.00 | NSC34 neuroblastoma x spinal c | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Biochemistry, Histamine. [PMID:32491722] | Patel, Rahimi | 2026 | 0 | |
| Ferroptosis and Cuproptosis in Cancer and Neurodegeneration: A Comprehensive Rev [PMID:41897286] | ["Tolbatov Iogann", "Marrone Alessandro" | Biomolecules | 2026 | 0 |
| Cell death in multiple sclerosis. [PMID:40926029] | Guan S, Zhu H, Zhang M, Shi FD, Yan B | Cell death and differentiation | 2026 | 0 |
| Astrocytic mGluR5-dependent calcium hyperactivity promotes amyloid-β pathology a [PMID:40377015] | Yang T, Zhang D, Huang H, Liu F, Wu J et | Brain | 2026 | 0 |
| Floss-based vaccination targets the gingival sulcus for mucosal and systemic imm [PMID:40696115] | Ingrole RSJ, Shakya AK, Joshi G, Lee CH, | Nat Biomed Eng | 2026 | 0 |
| Alzheimer and cardiovascular genetic scores and cognition: the FINGER randomized [PMID:40747850] | Saadmaan G, Dalmasso MC, Maria M, Lehtis | Brain | 2026 | 0 |
| In vivo chimeric antigen receptor (CAR)-T cell therapy. [PMID:41028170] | Bot A, Scharenberg A, Friedman K, Guey L | Nat Rev Drug Discov | 2026 | 0 |
| pTα enhances mRNA translation and potentiates CAR T cells for solid tumor eradic [PMID:41338193] | Shi Y, Lopez MA, Kotchetkov IS, Jain N, | Cell | 2026 | 0 |
| OMG! A proteomic determinant of neurodegenerative resiliency. [PMID:41491993] | Duggan MR, Oh HS, Frank P, Gomez GT, Zwe | Mol Neurodegener | 2026 | 0 |
| CDK10 suppresses nucleic acid sensors-mediated antitumor immunity. [PMID:41507536] | Xu G, Guo F, He C, Wang X, Xiang B et al | Nat Cancer | 2026 | 0 |
| Gut Dysbiosis and Microbiota-Derived Metabolites in Neurodegenerative Diseases: [PMID:41683467] | Czaj PV, Szewczyk-Golec K, Nuszkiewicz J | Molecules | 2026 | 0 |
| Bile acid-microbiota interactions in multiple sclerosis: From experimental model [PMID:41806463] | Atasever Ü | J Neuroimmunol | 2026 | 0 |
| The IL-23/IL-17 axis in Behçet's syndrome pathogenesis: from immunological persp [PMID:41884836] | Naffaa ME, Hassan F, Omar M, Abacar K, M | Front Immunol | 2026 | 0 |
| Glial Plasticity and Dysfunction: Mechanistic Insights and Therapeutic Opportuni [PMID:41906403] | Correale J | J Neurochem | 2026 | 0 |
| Neurodegeneration and Homelessness: A Bidirectional Relationship Shaping Health [PMID:41918504] | Stouffer ACF, Kumar SL | Yale J Biol Med | 2026 | 0 |
| Brain atrophy in multiple sclerosis: Mechanisms, measurement, and clinical trans [PMID:41934070] | Koubiyr I, Schoonheim MM | Rev Neurol (Paris) | 2026 | 0 |
| Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity. [PMID:41372408] | Tian X, Liu J, Li Y, Wang Y, Luo Y, He H | Nature | 2026 | 0 |
| A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis. [PMID:41349546] | Lorenz SM, Wahida A, Bostock MJ, Seibt T | Cell | 2026 | 0 |
| Long-Term Tofersen in SOD1 Amyotrophic Lateral Sclerosis. [PMID:41661214] | ["Miller Timothy M", "Cudkowicz Merit E" | JAMA neurology | 2026 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.63 · 2026-04-22
closed · Rounds: 4 · Score: 0.50 · 2026-04-20
closed · Rounds: 4 · Score: 0.86 · 2026-04-12
closed · Rounds: 5 · Score: 0.95 · 2026-04-12
closed · Rounds: 4 · Score: 0.90 · 2026-04-06
Hypotheses and analyses mentioning Multiple in their description or question text
Score: 0.466 · unknown disease · 2026-04-16
## Mechanistic Overview Cross-Tissue Communication Disruption starts from the claim that modulating MULTIPLE within the
Score: 0.000 · unknown disease · 2026-04-28
Creating controlled gradients of astrocyte subtypes across damaged brain regions could optimize both neuroprotection and
Score: 0.000 · unknown disease · 2026-04-28
Targeting cell type-specific aging signatures to restore coordinated cellular aging across brain cell types Debate prov
Score: 0.000 · unknown disease · 2026-04-28
AD pathology disrupts communication between different cell types. Single-cell analysis reveals both specific and common
Score: 0.000 · unknown disease · 2026-04-28
Targeting master metabolic regulators to reprogram astrocytes from inflammatory A1 to neuroprotective A2 states Debate