disease 2,192 words KG: ent-dise-9d3a7321 2026-03-29
kind:diseasesection:diseasestopic:msatopic:parkinsonstopic:synucleinopathies
Contents

Multiple System Atrophy

Disease Info
Prevalence2-5 per 100,000
Annual incidence0.6 per 100,000
Mean age at onset53-64 years
Gender distributionSlight male predominance (1.3-1.5:1)
Geographic variationMSA-C more common in Japan; MSA-P more common in Western countries
Disease durationMedian 6-10 years from onset
DatabasesOMIMOrphanetClinicalTrialsPubMed

Knowledge Graph

Related Hypotheses (15)

Smartphone-Detected Motor Variability Correction
Score: 0.56
Ferroptosis Inhibition for α-Synuclein Neuroprotection
Score: 0.55
HDAC6 Activation as SCFA-Mediated Neuroprotective Mechanism
Score: 0.54
Phase-Separated Organelle Targeting
Score: 0.52
Vocal Cord Neuroplasticity Stimulation
Score: 0.50

Related Analyses (10)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

Related Experiments (7)

Iron Dyshomeostasis in MSA Pathogenesis Experiment
validation · proposed · Score: 0.40
Alpha-Synuclein Spreading Mechanism — Prion-Like Propagation
exploratory · proposed · Score: 0.40
Validation: Membrane-Nucleation in iPSC Neurons
validation · proposed · Score: 0.40
TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.40
Longitudinal TLR2 reporter gene study in α-synuclein mice
validation · proposed · Score: 0.90