gene

NDUFB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NDUFB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4Connections

0Hypotheses

0Analyses

2Outgoing

2Incoming

0Experiments

Summary

NDUFB1 encodes an accessory subunit of mitochondrial Complex I, essential for electron transport chain function and implicated in neurodegeneration

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🧬 Gene Info

Gene Symbol	NDUFB1
Full Name	NADH:ubiquinone Oxidoreductase Subunit B1 (Complex I-B8)
Aliases	NADH:ubiquinone Oxidoreductase Subunit B1
Chromosome	2q33.3
Function	encodes a crucial accessory subunit of mitochondrial Complex I (NADH:ubiquinone oxidoreductase), the largest complex of the mitochondrial electron transport chain[@fearnley1992].
Primary Expression	Ubiquitous (highest in brain, heart, skeletal muscle)
Molecular Weight	11 kDa
Amino Acids	104 aa
Pathways	oxidative phosphorylation
UniProt ID	O75489
NCBI Gene ID	4706
Ensembl ID	ENSG00000170733
GeneCards	NDUFB1
Human Protein Atlas	NDUFB1
Protein Length	104 amino acids
Interactions	ATP5MC1, COX17
KG Connections	4 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NDUFB1 — AlphaFold O75489 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NDUFB1 — NADH:ubiquinone Oxidoreductase Subunit B1

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Genes

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Pathway Diagram

flowchart TD
    N0["NDUFB1"]
    N1["oxidative phosphorylation"]
    N0 -->|"regulates"| N1
    N2["neurodegeneration"]
    N0 -->|"implicated in"| N2

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 pathway

Outgoing (2)

Target	Relation	Type	Str
oxidative phosphorylation	regulates	pathway	0.70
mitochondrial function	participates_in	pathway	0.60

Incoming (2)

Source	Relation	Type	Str
ATP5MC1	activates	gene	0.60
COX17	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found