pathway

Oxidative Phosphorylation

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Oxidative Phosphorylation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1338Connections

0Hypotheses

1Analyses

43Outgoing

50Incoming

Summary

Oxidative Phosphorylation is a biological pathway involved in neurodegeneration research. Key relationships include: activates, interacts with, associated with. Associated with ALS, Aging, Als. Connected to 773 entities in the SciDEX knowledge graph.

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🔀 Pathway Info

Name	Oxidative Phosphorylation
Key Genes/Proteins	PI3K, AKT, CANCER, OXIDATIVE STRESS
Related Diseases	Cancer, Tumor, Als, Inflammation

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Oxidative_Phosphorylation["Oxidative Phosphorylation"] -->|"interacts"| Autophagy["Autophagy"]
    Oxidative_Phosphorylation["Oxidative Phosphorylation"] -->|"interacts"| Akt["Akt"]
    Oxidative_Phosphorylation["Oxidative Phosphorylation"] -->|"interacts"| Pi3K["Pi3K"]
    Oxidative_Phosphorylation["Oxidative Phosphorylation"] -->|"interacts"| Wnt["Wnt"]
    Oxidative_Phosphorylation["Oxidative Phosphorylation"] -->|"interacts"| Mapk["Mapk"]
    Oxidative_Phosphorylation["Oxidative Phosphorylation"] -->|"interacts"| Mtor["Mtor"]
    OPTN["OPTN"] -->|"interacts"| Oxidative_Phosphorylation["Oxidative Phosphorylation"]
    CASP3["CASP3"] -->|"interacts"| Oxidative_Phosphorylation["Oxidative Phosphorylation"]
    AKT1["AKT1"] -->|"interacts"| Oxidative_Phosphorylation["Oxidative Phosphorylation"]
    CALCOCO2["CALCOCO2"] -->|"interacts"| Oxidative_Phosphorylation["Oxidative Phosphorylation"]
    style Oxidative_Phosphorylation fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (190)

Target	Relation	Type	Str
Chronic Tendon Injury	therapeutic_target	disease	0.95
Lung Cancer Brain Metastasis	involved_in	disease	0.90
Tendon Homeostasis	associated_with	process	0.90
Necroptosis	suppresses	process	0.85
Ovarian Cancer	downregulates	disease	0.75
Autophagy	interacts_with	pathway	0.55
Akt	interacts_with	pathway	0.55
Pi3K	interacts_with	pathway	0.55
Wnt	interacts_with	pathway	0.55
Mapk	interacts_with	pathway	0.55
Mtor	interacts_with	pathway	0.55
Glycolysis	interacts_with	pathway	0.55
Nf-Κb	interacts_with	pathway	0.55
Stem Cell	interacts_with	cell_type	0.50
Dendritic Cell	interacts_with	cell_type	0.50
Epithelial	interacts_with	cell_type	0.50
Monocyte	associated_with	cell_type	0.50
Macrophage	associated_with	cell_type	0.50
Fibroblast	associated_with	cell_type	0.50
Macrophage	activates	cell_type	0.50
Macrophage	therapeutic_target	cell_type	0.50
Epithelial	activates	cell_type	0.50
Microglia	activates	cell_type	0.50
Astrocyte	phosphorylates	cell_type	0.50
Neuron	activates	cell_type	0.50
Microglia	phosphorylates	cell_type	0.50
Dopaminergic	activates	cell_type	0.50
Neuron	regulates	cell_type	0.50
Stem Cell	transports	cell_type	0.50
Neuron	transports	cell_type	0.50
Epithelial	encodes	cell_type	0.50
T Cell	encodes	cell_type	0.50
T Cell	therapeutic_target	cell_type	0.50
Neuron	therapeutic_target	cell_type	0.50
Oligodendrocyte	activates	cell_type	0.50
T Cell	causes	cell_type	0.50
T Cell	activates	cell_type	0.50
Endothelial	activates	cell_type	0.50
Fibroblast	inhibits	cell_type	0.50
T Cell	inhibits	cell_type	0.50
Stem Cell	associated_with	cell_type	0.50
T Cell	associated_with	cell_type	0.50
Neuron	associated_with	cell_type	0.50

Incoming (1148)

Source	Relation	Type	Str
PI3K	activates	gene	1.00
AKT	activates	gene	1.00
Cancer	activates	disease	1.00
Tumor	activates	disease	1.00
Als	therapeutic_target	disease	1.00
Als	activates	disease	1.00
Cancer	regulates	disease	1.00
Tumor	therapeutic_target	disease	1.00
Tumor	inhibits	disease	1.00
Inflammation	activates	disease	1.00
Als	regulates	disease	1.00
Inflammation	regulates	disease	1.00
CANCER	activates	gene	1.00
CANCER	therapeutic_target	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
CANCER	regulates	gene	1.00
APOPTOSIS	regulates	gene	1.00
ATP	activates	gene	1.00
ATP	associated_with	gene	1.00
MITOCHONDRIA	associated_with	gene	1.00
MITOCHONDRIAL DYSFUNCTION	activates	gene	1.00
Cancer	therapeutic_target	disease	1.00
ROS	activates	gene	1.00
MTOR	activates	gene	1.00
GENES	activates	gene	1.00
CANCER	inhibits	gene	1.00
MITOPHAGY	regulates	gene	1.00
Obesity	activates	disease	1.00
INFLAMMATION	regulates	gene	1.00
MITOCHONDRIAL DYSFUNCTION	treats	gene	1.00
Tumor	regulates	disease	0.95
Inflammasome	downregulates	process	0.95
PPARGC1A	mediates	gene	0.95
Gamitrinib	inhibits	drug	0.95
Astrocytic Mitochondria	involved_in	cell_type	0.95
mtDNA	involved_in	biomarker	0.95
Mtdna	associated_with	biomarker	0.95
Early Metastatic Epithelial Cell Clusters	involved_in	cell_type	0.90
COX15	involved_in	gene	0.90
NDUFA12	involved_in	gene	0.90
Mitochondrial Genome	associated_with	biomarker	0.90
MYC	activates	gene	0.90
Cancer	associated_with	disease	0.90
Cardiac	therapeutic_target	disease	0.90
Aging	activates	disease	0.90
P53	activates	gene	0.90
AUTOPHAGY	activates	gene	0.90
CANCER	associated_with	gene	0.90
MITOPHAGY	activates	gene	0.90
HIF	activates	gene	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Oxidative Phosphorylation

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Progressive Supranuclear Palsy (PSP)

Parkinson's Disease

CBS/PSP Supplements Guide

Parthanatos in Neurodegeneration

coq10-neurodegeneration

TREM2 Mechanism Hub

Mitochondrial Quality Control

Astrocyte Reactivity Mechanism

Mitochondrial Dysfunction in Parkinson's Disease

Circadian Rhythm in Neurodegeneration

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

oxidative-stress-comparison

APOC4 — Apolipoprotein C-IV

Coenzyme Q10 for Neurodegeneration

Mitochondrial Dysfunction in Neurodegeneration

Alpha-Synuclein Prion-Like Spreading Mechanisms in Parkinson's Disease

ZDHHC13 — Zinc Finger DHHC-Type Containing 13

Excitotoxicity in Neurodegeneration