Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about mitochondrial function: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | mitochondrial function |
| Key Genes/Proteins | TFEB, SIRT1, ROS, RNA, PINK1, TDP-43 |
| Related Diseases | Parkinson's disease, neurodegeneration |
| Related Pathways | carnitine metabolism |
Knowledge base pages for this entity
graph TD
mitochondrial_function["mitochondrial function"] -->|"protects against"| Cerebral_Ischemia_Reperfusion_["Cerebral Ischemia-Reperfusion Injury"]
style Cerebral_Ischemia_Reperfusion_ fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
mitochondrial_function["mitochondrial function"] -->|"mediates"| ferroptosis["ferroptosis"]
style ferroptosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
mitochondrial_function["mitochondrial function"] -->|"mediates"| axonal_transport["axonal transport"]
style axonal_transport fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
mitochondrial_function["mitochondrial function"] -->|"mediates"| protein_misfolding["protein misfolding"]
style protein_misfolding fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
mitochondrial_function["mitochondrial function"] -->|"mediates"| pyroptosis["pyroptosis"]
style pyroptosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
mitochondrial_function["mitochondrial function"] -->|"mediates"| calcium_signaling["calcium signaling"]
style calcium_signaling fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
TFEB["TFEB"] -->|"activates"| mitochondrial_function["mitochondrial function"]
style TFEB fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
SIRT1["SIRT1"] -->|"regulates"| mitochondrial_function["mitochondrial function"]
style SIRT1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
HADHA_lactylation["HADHA lactylation"] -.->|"inhibits"| mitochondrial_function["mitochondrial function"]
style HADHA_lactylation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
metformin["metformin"] -->|"regulates"| mitochondrial_function["mitochondrial function"]
style metformin fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
carnitine_metabolism["carnitine metabolism"] -->|"regulates"| mitochondrial_function["mitochondrial function"]
style carnitine_metabolism fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
style mitochondrial_function fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| Cerebral Ischemia-Reperfusion Injury | protects_against | disease | 0.85 |
| ferroptosis | mediates | process | 0.60 |
| axonal transport | mediates | process | 0.60 |
| protein misfolding | mediates | process | 0.60 |
| pyroptosis | mediates | process | 0.60 |
| calcium signaling | mediates | process | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TFEB | activates | gene | 0.95 |
| SIRT1 | regulates | gene | 0.90 |
| HADHA lactylation | inhibits | process | 0.90 |
| metformin | regulates | drug | 0.90 |
| carnitine metabolism | regulates | pathway | 0.90 |
| ROS | participates_in | gene | 0.90 |
| Parkinson's disease | involves | disease | 0.90 |
| RNA | participates_in | gene | 0.90 |
| PINK1 | participates_in | gene | 0.90 |
| neurodegeneration | involves | disease | 0.90 |
| TDP-43 | impairs | protein | 0.90 |
| MIRO1 | modulates | protein | 0.90 |
| AMPK | activates | protein | 0.90 |
| SIRT1 | activates | protein | 0.90 |
| PPARD | regulates | gene | 0.90 |
| Palmitic acid | associated_with | compound | 0.90 |
| radiofrequency radiation | inhibits | compound | 0.88 |
| Luteolin | restores | drug | 0.85 |
| calcium signaling | regulates | pathway | 0.85 |
| DAM microglia | active_in | cell_type | 0.85 |
| astrocytes | active_in | cell_type | 0.85 |
| neurons | active_in | cell_type | 0.85 |
| NRF1 | participates_in | gene | 0.85 |
| nicotinamide | modulates | drug | 0.85 |
| NRF2 | participates_in | gene | 0.85 |
| oleuropein | associated_with | compound | 0.85 |
| 116B | associated_with | compound | 0.85 |
| time-restricted feeding | associated_with | process | 0.85 |
| TFAM | regulates | gene | 0.85 |
| m6A methylation | associated_with | process | 0.85 |
| bilirubin | inhibits | phenotype | 0.80 |
| spermidine | associated_with | drug | 0.80 |
| resveratrol | associated_with | drug | 0.80 |
| PI3K/AKT | regulates | pathway | 0.80 |
| AMPK | participates_in | gene | 0.80 |
| ALS | participates_in | gene | 0.80 |
| DRP1 | participates_in | gene | 0.80 |
| DNA | participates_in | gene | 0.80 |
| PI3K | participates_in | gene | 0.80 |
| ATP | participates_in | gene | 0.80 |
| neuroinflammation | involves | disease | 0.80 |
| Huntington's disease | involves | disease | 0.80 |
| α-synuclein | impairs | protein | 0.80 |
| TOM40 | involved_in | protein | 0.80 |
| AKT1 | regulates | gene | 0.80 |
| stroke | involves | disease | 0.80 |
| ULK1 | participates_in | gene | 0.80 |
| TFEB | participates_in | gene | 0.75 |
| BDNF | participates_in | gene | 0.75 |
| SIRT1 | participates_in | gene | 0.75 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-13 | 0 hypotheses
neurodegeneration | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||