Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NEUROD2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NEUROD2 encodes a calcium-responsive bHLH transcription factor critical for neuronal differentiation, synapse formation, synaptic plasticity, and memory consolidation. Linked to neurodevelopmental disorders, Alzheimer's, Parkinson's, and Huntington's disease.
| Gene Symbol | NEUROD2 |
| Aliases | NDRF, NPAS2-related |
| Chromosome | 17q12 |
| Protein Type | Transcription Factor |
| Function | Binding to DNA recruits co-activators including p300/CBP, leading to histone acetylation and transcription initiation[@patzke2020]. |
| Primary Expression | Brain (cerebellum, hippocampus, cortex); peripheral neurons |
| Molecular Weight | ~39 kDa |
| Amino Acids | 354 aa |
| UniProt ID | Q15784 |
| NCBI Gene ID | 4760 |
| GeneCards | NEUROD2 |
| Human Protein Atlas | NEUROD2 |
| Protein Length | 354 amino acids |
| Protein Class | bHLH transcription factor |
| TCF12 | Heterodimerization |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, Huntington's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NEUROD2["<b>NEUROD2</b>"]
neurodegeneration["neurodegeneration"]
NEUROD2 -->|"implicated in"| neurodegeneration
Alzheimer_S{"Alzheimer'S"}
NEUROD2 -->|"implicated in"| Alzheimer_S
Huntington_S_Disease{"Huntington'S Disease"}
NEUROD2 -->|"implicated in"| Huntington_S_Disease
Parkinson_S{"Parkinson'S"}
NEUROD2 -->|"implicated in"| Parkinson_S
Synaptic_Plasticity(["Synaptic Plasticity"])
NEUROD2 -->|"regulates"| Synaptic_Plasticity
Transcription(["Transcription"])
NEUROD2 -->|"regulates"| Transcription
CALCIUM["CALCIUM"]
NEUROD2 ---|"interacts"| CALCIUM
style NEUROD2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
style Alzheimer_S fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
style Parkinson_S fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
style Huntington_S_Disease fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
style Synaptic_Plasticity fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f
style Transcription fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity