disease

Huntington's disease

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Huntington's disease: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1702Connections

0Hypotheses

0Analyses

37Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	STING1, HACE1, GFM1, HSF1, huntingtin, NEAT1, RCAN1, BDNF
Therapeutic Agents	DH1, antisense oligonucleotides, ginsenosides, RB5, Berbamine hydrochloride, resveratrol
KG Connections	327 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Huntington_s_disease["Huntington's disease"] -->|"affects"| cerebellum["cerebellum"]
    style cerebellum fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Huntington_s_disease["Huntington's disease"] -->|"affects"| neurons["neurons"]
    style neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Huntington_s_disease["Huntington's disease"] -->|"affects"| astrocytes["astrocytes"]
    style astrocytes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Huntington_s_disease["Huntington's disease"] -->|"affects"| striatum["striatum"]
    style striatum fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Huntington_s_disease["Huntington's disease"] -->|"involves"| oxidative_stress_response["oxidative stress response"]
    style oxidative_stress_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Huntington_s_disease["Huntington's disease"] -->|"affects"| neural_stem_cells["neural stem cells"]
    style neural_stem_cells fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Huntington_s_disease["Huntington's disease"] -->|"disrupts"| mitochondria["mitochondria"]
    style mitochondria fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ALS["ALS"] -->|"associated"| Huntington_s_disease["Huntington's disease"]
    style ALS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    HTT["HTT"] -->|"causes"| Huntington_s_disease["Huntington's disease"]
    style HTT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    Reactive_astrogliosis["Reactive astrogliosis"] -->|"contributes to"| Huntington_s_disease["Huntington's disease"]
    style Reactive_astrogliosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    RB5["RB5"] -->|"treats"| Huntington_s_disease["Huntington's disease"]
    style RB5 fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Berbamine_hydrochloride["Berbamine hydrochloride"] -->|"treats"| Huntington_s_disease["Huntington's disease"]
    style Berbamine_hydrochloride fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    style Huntington_s_disease fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (820)

Target	Relation	Type	Str
cerebellum	affects	brain_region	0.90
neurons	affects	cell_type	0.90
astrocytes	affects	cell_type	0.90
striatum	affects	brain_region	0.90
oxidative stress response	involves	pathway	0.90
neural stem cells	affects	cell_type	0.90
ferroptosis	involves	pathway	0.80
unfolded protein response	involves	pathway	0.80
autophagy pathway	involves	pathway	0.80
mitochondrial function	involves	pathway	0.80
spinal cord	affects	brain_region	0.70
microglia	affects	cell_type	0.70
pyroptosis	involves	pathway	0.70
hippocampus	affects	brain_region	0.70
temporal lobe	affects	brain_region	0.70
cGAS-STING	involves	pathway	0.70
calcium signaling	involves	pathway	0.70
ubiquitin-proteasome	involves	pathway	0.70
pericytes	affects	cell_type	0.60
basal ganglia	affects	brain_region	0.60
necroptosis	involves	pathway	0.60
lipid metabolism	involves	pathway	0.60
substantia nigra	affects	brain_region	0.60
cortex	affects	brain_region	0.60
epigenetic regulation	involves	pathway	0.60
apoptosis pathway	involves	pathway	0.60
Hippo signaling	involves	pathway	0.60
blood-brain barrier	affects	brain_region	0.60
CRISPR-Cas	involves	pathway	0.60
JAK-STAT signaling	involves	pathway	0.60
PI3K-AKT-mTOR signaling	involves	pathway	0.60
MAPK signaling	involves	pathway	0.60
Wnt signaling	involves	pathway	0.60
NAD+ metabolism	involves	pathway	0.55
circadian regulation	involves	pathway	0.55
neurotrophin signaling	involves	pathway	0.55
blood-brain barrier	involves	pathway	0.55

Incoming (882)

Source	Relation	Type	Str
ALS	associated_with	gene	0.90
HTT	causes	gene	0.90
Reactive astrogliosis	contributes_to	process	0.90
RB5	treats	drug	0.87
Berbamine hydrochloride	treats	compound	0.85
GFAP	biomarker_for	protein	0.85
White matter loss	associated_with	phenotype	0.85
BDNF	associated_with	gene	0.80
SQSTM1	therapeutic_target	protein	0.80
ALS	activates	gene	0.80
ALS	implicated_in	gene	0.80
HTT	associated_with	gene	0.80
HTT	treats	gene	0.80
NEAT1	upregulated_in	gene	0.80
BDNF	downregulated_in	gene	0.80
IGF2	implicated_in	gene	0.80
MIR-34A-5P	implicated_in	molecule	0.80
ERRγ	regulates	gene	0.80
TCF4	dysregulated_in	gene	0.80
DNAJB6	prevents	protein	0.80
PARTHANATOS	implicated_in	process	0.80
ATXN1	causes	gene	0.80
ASK1	implicated_in	gene	0.80
HUNTINGTIN	implicated_in	gene	0.80
NPY	implicated_in	gene	0.80
MTOR	implicated_in	gene	0.80
PARP1	implicated_in	gene	0.80
Autophagy-lysosomal pathway	associated_with	pathway	0.70
insulin resistance	associated_with	process	0.70
autophagy-lysosomal pathway	associated_with	pathway	0.70
ferroptosis	associated_with	process	0.70
STING1	associated_with	protein	0.70
HACE1	associated_with	protein	0.70
GFM1	associated_with	gene	0.70
circadian rhythm	associated_with	process	0.70
autophagy	associated_with	process	0.70
PPARGC1A	protects_against	gene	0.70
HSF1	associated_with	protein	0.70
DH1	treats	drug	0.70
NRF2	protects_against	protein	0.70
huntingtin	causes	protein	0.70
antisense oligonucleotides	treats	drug	0.70
protein misfolding	causes	process	0.70
STAT3	regulates	protein	0.70
reactive astrocytes	associated_with	cell_type	0.70
ginsenosides	treats	drug	0.70
NEAT1	associated_with	gene	0.70
JAK2-STAT3 pathway	associated_with	pathway	0.70
RCAN1	associated_with	protein	0.70
striatum	associated_with	brain_region	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Huntington's disease

Understanding Entity Pages

Wiki Pages (20)

Novel Therapy Index

Parkinson's Disease

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

Neurons — Cell Type Hierarchy

neuroinflammation

NRF2 Oxidative Stress Pathway

Microglial Cells — Cell Type Hierarchy

coq10-neurodegeneration

Mitochondrial Quality Control

Astrocyte Reactivity Mechanism

GSK-3β in Neurodegeneration

Growth Factor Therapies

Circadian Rhythm in Neurodegeneration

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Autophagy Mechanisms

Oligodendrocytes

oxidative-stress-comparison