Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NF-KAPPAB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | NF |
| Full Name | KAPPAB |
| Function | Nf Κb P105 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| GeneCards | NF |
| Human Protein Atlas | NF |
| Interactions | MAPK, C-MYC, SIGMA1R, POLY-PR |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NF_KAPPAB["NF-KAPPAB"]
MAPK["MAPK"]
NF_KAPPAB -->|"activates"| MAPK
C_MYC["C-MYC"]
NF_KAPPAB -->|"activates"| C_MYC
microglia["microglia"]
microglia -->|"activates"| NF_KAPPAB
style NF_KAPPAB fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7| Target | Relation | Type | Str |
|---|---|---|---|
| chemokine expression | contributes_to | phenotype | 0.80 |
| MAPK | activates | gene | 0.50 |
| C-MYC | activates | gene | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| gallic acid | inhibits | drug | 0.90 |
| LPS | activates | drug | 0.90 |
| p62 aggregates | activates | phenotype | 0.80 |
| TNF | activates | entity | 0.80 |
| ADRA2B | activates | gene | 0.80 |
| SIGMA1R | interacts_with | gene | 0.80 |
| POLY-PR | activates | protein | 0.80 |
| microglia | activates | cell_type | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||