gene

MAPK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAPK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5781Connections

1Hypotheses

4Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	MAPK
Associated Diseases	ALS, ALZHEIMER'S DISEASE, ASTROGLIOSIS, Aging, Alzheimer
Known Drugs/Compounds	RAPAMYCIN, N-ACETYLCYSTEINE, QUERCETIN, TRAMETINIB, LPS, gallic acid
Interactions	NLRP3, OPTN, P62, PARKIN, PINK1, RAS
KG Connections	3273 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    MAPK["<b>MAPK</b>"]
    Neurodegeneration{"Neurodegeneration"}
    MAPK -->|"involved_in"| Neurodegeneration
    mTOR(["mTOR"])
    MAPK -->|"regulates"| mTOR
    mitophagy["mitophagy"]
    MAPK -->|"regulates"| mitophagy
    type_2_diabetes_mellitus{"type 2 diabetes mellitus"}
    MAPK -->|"associated_with"| type_2_diabetes_mellitus
    Alzheimer_s_disease{"Alzheimer's disease"}
    MAPK -->|"associated_with"| Alzheimer_s_disease
    STAT3(["STAT3"])
    MAPK -->|"activates"| STAT3
    LPS["["LPS""]]
    LPS -->|"activates"| MAPK
    gallic_acid["["gallic acid""]]
    gallic_acid -.->|"inhibits"| MAPK
    paeoniflorin["["paeoniflorin""]]
    paeoniflorin -.->|"inhibits"| MAPK
    ginseng_root_extract["["ginseng root extract""]]
    ginseng_root_extract -.->|"inhibits"| MAPK
    style MAPK fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#e0e0e0

Outgoing (2023)

Target	Relation	Type	Str
gastric cancer	associated_with	disease	0.95
Mitochondrial Fission	activates	process	0.90
colitis-associated colorectal cancer	associated_with	disease	0.90
cellular proliferation	regulates	process	0.90
cell migration	regulates	process	0.90
metastasis	promotes	process	0.90
ATF2	upstream_of	protein	0.90
liver fibrosis	associated_with	disease	0.90
MAPK signaling	participates_in	pathway	0.90
PI3K-AKT-mTOR signaling	participates_in	pathway	0.90
neuroinflammation	inhibits	disease	0.90
unfolded protein response	participates_in	pathway	0.90
NF-kB signaling	participates_in	pathway	0.90
oxidative stress response	participates_in	pathway	0.90
ubiquitin-proteasome	participates_in	pathway	0.90
neurons	expressed_in	cell_type	0.90
DRP1	phosphorylates	protein	0.90
ADIPOR1	activates	protein	0.90
TDP-43	phosphorylates	protein	0.90
LCH	drives	disease	0.90
inflammatory cytokine secretion	promotes	process	0.88
oxidative stress	promotes	process	0.88
neuroinflammation	regulates	process	0.86
Neurodegeneration	involved_in	disease	0.85
PILOCYTIC ASTROCYTOMAS	involved_in	entity	0.85
microglia activation	activates	process	0.85
microglia activation	regulates	process	0.85
microglia	expressed_in	cell_type	0.85
cholangiocarcinoma	therapeutic_target	disease	0.85
cell survival	promotes	process	0.85
microglia	modulates	cell_type	0.85
inflammation	drives	process	0.85
astrocyte activation	activates	process	0.83
Alzheimer's disease	upstream_of	disease	0.82
mTOR	regulates	protein	0.80
RASopathy	associated_with	disease	0.80
multiple sclerosis	therapeutic_target	disease	0.80
mitochondrial dysfunction	regulates	process	0.80
JAK-STAT signaling	participates_in	pathway	0.80
neurodegeneration	activates	disease	0.80
PI3K	implicated_in	gene	0.80
neurons	activates	cell_type	0.80
stem cells	expressed_in	cell_type	0.80
astrocytes	expressed_in	cell_type	0.80
DUX4	regulates	gene	0.80
neuroinflammation	mediates	process	0.80
ELF3	regulates	gene	0.80
PI3K/AKT	interacts_with	pathway	0.80
antioxidant signaling	activates	pathway	0.80
cytokine-cytokine receptor interaction	involved_in	pathway	0.80

Incoming (3758)

Source	Relation	Type	Str
AKT	associated_with	gene	1.00
NF-KB	associated_with	protein	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
AMYLOID	associated_with	protein	1.00
PI3K	activates	pathway	0.98
MTOR	activates	gene	0.98
ERK	associated_with	gene	0.98
MICROGLIA	associated_with	cell_type	0.98
PARKINSON'S DISEASE	associated_with	disease	0.98
TNF	associated_with	gene	0.98
MASP1	activates	protein	0.95
LPS	activates	drug	0.90
gallic acid	inhibits	drug	0.90
paeoniflorin	inhibits	drug	0.90
ginseng root extract	inhibits	drug	0.90
MTOR	associated_with	gene	0.90
TAU	associated_with	protein	0.90
AKT	activates	gene	0.90
IL-6	associated_with	gene	0.90
KRAS	activates	gene	0.90
JNK	upstream_of	protein	0.90
p38	upstream_of	protein	0.90
MAP2K1	activates	protein	0.90
IGF1R	activates	protein	0.90
TMPC-ANXA2 Interaction	activates	mechanism	0.90
Trametinib	inhibits	drug	0.90
CHOLIX	activates	drug	0.90
CD97	activates	protein	0.90
BEST3	inhibits	gene	0.90
Dihydrotestosterone	suppresses	compound	0.88
QQHCF	modulates	drug	0.85
Helicobacter pylori	activates	protein	0.85
Epstein-Barr virus	activates	protein	0.85
lithium chloride	modulates	drug	0.85
MGO	activates	metabolite	0.85
dabrafenib	inhibits	drug	0.85
trametinib	inhibits	drug	0.85
Pcs	modulates	compound	0.85
CASP3	associated_with	gene	0.82
ALS	associated_with	disease	0.82
PI3K	associated_with	gene	0.82
TARDBP	associated_with	gene	0.82
AKT	regulates	gene	0.82
ASTROCYTES	associated_with	cell_type	0.82
phosphoproteomics	associated_with	process	0.82
116B	inhibits	compound	0.82
STING1	activates	protein	0.80
STING	activates	protein	0.80
AKT	interacts_with	gene	0.80
NF1	regulates	gene	0.80

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
DLK MAPK Pathway Inhibition to Block Tau-Induced Neurotoxici	0.609	neurodegeneration	Should microtubule-stabilizing drugs be

Mentioning Analyses (4)

Scientific analyses that reference this entity

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.487

Digital biomarkers and AI-driven early detection of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.605

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.521

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.617

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MAPK

Understanding Entity Pages

Wiki Pages (20)

Progressive Supranuclear Palsy (PSP)

Parkinson's Disease

Alzheimer's Disease Mechanism Index

Therapeutics

neuroinflammation

NRF2 Oxidative Stress Pathway

NTF4 Protein

TREM2 Mechanism Hub

Astrocyte Reactivity Mechanism

GSK-3β in Neurodegeneration

Growth Factor Therapies

ncam2

Neurotrophin Signaling Pathways in Neurodegeneration

amyloid-beta-metalloproteinases

TREM2 Microglial Signaling Pathway in Neurodegeneration

CNTN6 — Contactin 6

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases

Vitamin D Signaling Pathway in Neurodegeneration

CNTN4 — Contactin 4

VEGF/Angiogenesis Pathway in Neurodegeneration