gene

ADRA2B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ADRA2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

77Connections

0Hypotheses

0Analyses

49Outgoing

28Incoming

Summary

ADRA2B is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, exacerbates. Connected to 12 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	ADRA2B
Full Name	Alpha-2B Adrenergic Receptor
Chromosome	2q24.1
Protein Family	Adrenergic receptor family (GPCR)
Primary Expression	both the central and peripheral nervous systems, where it regulates norepinephrine release, blood pressure, and various autonomic functions
Molecular Weight	60 kDa
Amino Acids	450 aa
Pathways	PI3-K, Wnt
UniProt ID	P17787
NCBI Gene ID	151
Ensembl ID	ENSG00000159692
GeneCards	ADRA2B
Human Protein Atlas	ADRA2B
Protein Class	G protein-coupled receptor (Class A)
Brain Expression	Brainstem, Cortex, Hippocampus, Hypothalamus
Associated Diseases	neurodegeneration
Interactions	IL13, WNT11, TNFRSF1B, TNFRSF13C, MYO7A, WNT1
KG Connections	77 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ADRA2B — AlphaFold P17787 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ADRA2B["<b>ADRA2B</b>"]
    NF_kappaB["NF-kappaB"]
    ADRA2B -->|"activates"| NF_kappaB
    p21_waf_1_["p21(waf-1)"]
    ADRA2B -->|"upregulates"| p21_waf_1_
    Rab8["Rab8"]
    ADRA2B -->|"binds"| Rab8
    GGA3["GGA3"]
    ADRA2B -->|"binds"| GGA3
    cell_surface_expression["cell surface expression"]
    ADRA2B -->|"regulates"| cell_surface_expression
    air_pollution_induced_behavior_changes["air pollution-induced behavior changes"]
    ADRA2B -->|"exacerbates"| air_pollution_induced_behavior_changes
    air_pollution_induced_blood_pressure_cha["air pollution-induced blood pressure changes"]
    ADRA2B -->|"exacerbates"| air_pollution_induced_blood_pressure_cha
    ERK1_2["ERK1/2"]
    ADRA2B -->|"activates"| ERK1_2
    PI3_K(["PI3-K"])
    ADRA2B -->|"activates"| PI3_K
    ERK1_2_activation["ERK1/2 activation"]
    ADRA2B -->|"regulates"| ERK1_2_activation
    cAMP_inhibition["cAMP inhibition"]
    ADRA2B -->|"regulates"| cAMP_inhibition
    neurodegeneration["neurodegeneration"]
    ADRA2B -->|"implicated in"| neurodegeneration
    style ADRA2B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (49)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
NF-kappaB	activates	transcription_factor	0.80
p21(waf-1)	upregulates	gene	0.80
Rab8	binds	protein	0.80
GGA3	binds	protein	0.80
cell surface expression	regulates	phenotype	0.80
air pollution-induced behavior changes	exacerbates	phenotype	0.80
air pollution-induced blood pressure changes	exacerbates	phenotype	0.80
PI3-K	activates	pathway	0.70
ERK1/2 activation	regulates	biological_process	0.70
cAMP inhibition	regulates	biological_process	0.70
ERK1/2	activates	protein	0.70
Als	activates	disease	0.65
ALS	activates	disease	0.65
IL13	activates	gene	0.60
CHRNE	expressed_in	gene	0.60
WNT11	activates	gene	0.60
GRIN3B	expressed_in	gene	0.60
TNFRSF1B	activates	gene	0.60
TNFRSF13C	activates	gene	0.60
HCRTR1	expressed_in	gene	0.60
GRM2	expressed_in	gene	0.60
MYO7A	activates	gene	0.60
WNT1	activates	gene	0.60
Rb	expressed_in	protein	0.60
MBD2	expressed_in	gene	0.60
AKT	expressed_in	gene	0.60
MAPK14	associated_with	gene	0.60
GABA	expressed_in	gene	0.60
CYTOKINES	activates	gene	0.60
Wnt	activates	pathway	0.60
Microglia	activates	cell_type	0.60
Astrocyte	activates	cell_type	0.60
AND	expressed_in	gene	0.60
GENES	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
Cytokine	activates	protein	0.60
ERK1/2	expressed_in	gene	0.60
MAPK	expressed_in	gene	0.60
Dna Methylation	expressed_in	pathway	0.60
Epigenetic	expressed_in	pathway	0.60
Erk	expressed_in	protein	0.60
Ras	expressed_in	protein	0.60
Pi3K	expressed_in	protein	0.60
Brainstem	expressed_in	brain_region	0.55
Astrocyte	expressed_in	cell_type	0.55
Microglia	expressed_in	cell_type	0.55
GLUTAMATE	expressed_in	concept	0.50
benchmark_ot_ad_answer_key:ADRA2B	data_in	dataset_row	0.00

Incoming (28)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
CHRM4	expressed_in	gene	0.60
MYO7A	activates	gene	0.60
GRM2	expressed_in	gene	0.60
WNT1	activates	gene	0.60
CRH	expressed_in	gene	0.60
TNFRSF1B	activates	gene	0.60
GRIN3B	expressed_in	gene	0.60
HCRTR1	expressed_in	gene	0.60
WNT11	activates	gene	0.60
IL13	activates	gene	0.60
CHRNE	expressed_in	gene	0.60
TNFRSF13C	activates	gene	0.60
ADRA2A	expressed_in	gene	0.60
DNMT3B	expressed_in	gene	0.60
DNMT1	expressed_in	gene	0.60
DNMT3A	expressed_in	gene	0.60
PI3K	expressed_in	gene	0.60
ASTROCYTE	activates	gene	0.60
WNT	activates	gene	0.60
CYTOKINES	activates	gene	0.60
RNA	expressed_in	gene	0.60
ERK	expressed_in	gene	0.60
DNA	expressed_in	gene	0.60
ADRA2A	activates	gene	0.55
acetylcholine	expressed_in	disease	0.50
GABA	expressed_in	gene	0.50
benchmark_ot_ad_answer_key:ADRA2B	data_in	dataset_row	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ADRA2B

Understanding Entity Pages

Summary

Wiki Pages (21)

adra2b Gene

Interstitial Nucleus of Cajal

BAFFR Gene (TNFRSF13C)

WNT11 Gene

A2 Noradrenergic Neurons

Alpha-2 Adrenergic Receptor Neurons

Noradrenergic Neurons (Locus Coeruleus)

ADRA2C Protein (Alpha-2C Adrenergic Receptor)

WNT1 Gene

Locus Coeruleus Alpha-2 Adrenergic Neurons

Cortical Chandelier Cells

Laterodorsal Tegmental Nucleus GABAergic Neurons

Median Preoptic Nucleus in Sleep Pressure

Guanfacine NorAD - Phase 3 Trial for Alzheimer's Disease

Lateral Lemniscus Neurons

Cortical Basket Cells (Parvalbumin-Positive)

Dorsal Raphe Nucleus

DNMT3B Gene

NF-kappaB