gene

NTN2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about NTN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Netrin-2 is a laminin-related protein involved in axon guidance during neural development.

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🧬 Gene Info

Gene Symbol	NTN2
Full Name	Netrin-2
Chromosome	19p13.3
Protein Family	Netrin
Function	is a secreted laminin-related protein that plays crucial roles in axon guidance during neural development.
Primary Expression	spinal cord, brainstem, and cerebellum
Pathways	Axon Guidance
UniProt ID	[Q8WWS8](https://www.uniprot.org/uniprot/Q8WWS8)
GeneCards	NTN2
Human Protein Atlas	NTN2
N-terminal domain	Contains the receptor-binding sites for DCC and UNC5 family receptors
Laminin VI domain	Shared with laminin proteins, mediates heparin binding
Laminin V domain	C-terminal domain important for secretion and extracellular matrix interaction
C-terminal domain	Contains a heparin-binding site that regulates gradient formation
Neogenin	A DCC homolog that also binds netrins, involved in tissue boundary formation
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NTN2["NTN2"]
    neurodegeneration["neurodegeneration"]
    NTN2 -->|"implicated_in"| neurodegeneration
    style NTN2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning NTN2 in their description or question text

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