protein

OGDHPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OGDHPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

Summary

Ogdh Protein is involved in cellular processes relevant to neurodegeneration. For detailed information, refer to the References section.

View on Wiki →

🔬 Protein Info

Gene Symbol	OGDHPROTEIN
Protein Type	Enzyme
Function	is a multienzyme complex consisting of three subunits: OGDH (E1α), DLST (E2), and DLD (E3).
Molecular Weight	116 kDa
GeneCards	OGDHPROTEIN
Human Protein Atlas	OGDHPROTEIN
Citric Acid Cycle	The metabolic pathway in which OGDH serves as a rate-limiting enzyme
Mitochondrial Dysfunction	A common feature of neurodegenerative diseases involving OGDH impairment
NAD+ Metabolism	Critical cofactor pathway increasingly targeted therapeutically
Oxidative Stress	Primary mechanism of OGDH inactivation in neurodegeneration
Associated Diseases	neurodegeneration
Interactions	PINK1, PTEN, SOD1, MTORC1, MITOCHONDRIAL DYSFUNCTION, DNA
KG Connections	42 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Alpha-Ketoglutarate Dehydrogenase Protein

protein · 644 words

→

Pathway Diagram

graph TD
    OGDHPROTEIN["OGDHPROTEIN"]
    neurodegeneration["neurodegeneration"]
    OGDHPROTEIN -->|"implicated_in"| neurodegeneration
    style OGDHPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found