Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DNA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DNA is a protein involved in neurodegeneration research. Key relationships include: activates, associated with, interacts with. Associated with AD, ALI, ALS. Connected to 2929 entities in the SciDEX knowledge graph.
| Gene Symbol | DNA |
| Function | is an epigenetic modification that regulates gene expression without changing the DNA sequence. |
| Pathways | AMPK signaling, Adaptive Immunity, Akt, Amyloid, Angiogenesis |
| GeneCards | DNA |
| Human Protein Atlas | DNA |
| Biomarker Type | Epigenetic (DNA modification) |
| Target | CpG sites across the genome |
| Sample Types | Blood, Brain tissue, CSF |
| Detection Method | Bisulfite sequencing, EPIC array, Methylation arrays |
| Key Sites | Horvath clock sites, PHD1, ELOVL2 |
| Associated Diseases | AD, ALI, ALS, AMI, ARM, Addiction |
| Known Drugs/Compounds | rapamycin, metformin, ketamine, valproic acid, resveratrol |
| Interactions | MAPT, FAS, PEN2, APH1B, PSEN1, TARDBP |
| KG Connections | 5631 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
subgraph Signaling["Signaling"]
DNA["DNA"] -->|"activates"| CGAS["CGAS"]
DNA["DNA"] -.->|"inhibits"| Cancer_2["Cancer"]
DNA["DNA"] -.->|"inhibits"| Tumor_3["Tumor"]
STING["STING"] -->|"activates"| DNA["DNA"]
CGAS_4["CGAS"] -->|"activates"| DNA["DNA"]
MTDNA["MTDNA"] -->|"activates"| DNA["DNA"]
MITOCHONDRIAL_DNA_5["MITOCHONDRIAL DNA"] -->|"activates"| DNA["DNA"]
end
subgraph Pathology["Pathology"]
DNA["DNA"] -->|"associated with"| GENES["GENES"]
DNA["DNA"] -->|"associated with"| Alzheimer["Alzheimer"]
DNA["DNA"] -->|"associated with"| Als_1["Als"]
ROS["ROS"] -->|"causes"| DNA["DNA"]
MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"] -->|"associated with"| DNA["DNA"]
end
subgraph Therapeutic["Therapeutic"]
DNA["DNA"] -->|"therapeutic target"| Cancer["Cancer"]
DNA["DNA"] -->|"expressed in"| Als["Als"]
end
subgraph Interactions["Interactions"]
DNA["DNA"] -->|"interacts with"| Tumor["Tumor"]
end
style DNA fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style CGAS fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style GENES fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Cancer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Alzheimer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Als_1 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Tumor fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Cancer_2 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Tumor_3 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style ROS fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MITOCHONDRIAL_DNA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style STING fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style CGAS_4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MTDNA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MITOCHONDRIAL_DNA_5 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| CGAS | activates | protein | 1.00 |
| GENES | associated_with | gene | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Als | expressed_in | disease | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| Tumor | interacts_with | disease | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Innate Immunity | activates | pathway | 1.00 |
| Cancer | regulates | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Tumor | regulates | disease | 1.00 |
| Cardiovascular | therapeutic_target | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Epigenetic | therapeutic_target | pathway | 1.00 |
| Als | interacts_with | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Cancer | interacts_with | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Aging | activates | disease | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Amyotrophic Lateral Sclerosis | interacts_with | disease | 1.00 |
| Aging | regulates | disease | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Epigenetic | regulates | pathway | 1.00 |
| Cancer | contributes_to | disease | 1.00 |
| Dna Methylation | associated_with | pathway | 1.00 |
| Alzheimer | therapeutic_target | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Immune Response | activates | pathway | 1.00 |
| Epigenetic | activates | pathway | 1.00 |
| Cancer | activates | disease | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Dna Methylation | regulates | pathway | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Epigenetic | associated_with | pathway | 1.00 |
| GENES | activates | gene | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Als | contributes_to | disease | 1.00 |
| Aging | associated_with | disease | 1.00 |
| Immune Response | associated_with | pathway | 1.00 |
| Carcinoma | associated_with | disease | 1.00 |
| Ferroptosis | activates | pathway | 1.00 |
| GENES | regulates | gene | 1.00 |
| Amyotrophic Lateral Sclerosis | therapeutic_target | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Cancer | biomarker_for | disease | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ROS | causes | phenotype | 1.00 |
| MITOCHONDRIAL DNA | associated_with | gene | 1.00 |
| STING | activates | gene | 1.00 |
| CGAS | activates | gene | 1.00 |
| MTDNA | activates | gene | 1.00 |
| MITOCHONDRIAL DNA | activates | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| GENES | regulates | gene | 1.00 |
| GENES | associated_with | gene | 1.00 |
| MTDNA | associated_with | gene | 1.00 |
| GENES | inhibits | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
| GENES | expressed_in | gene | 1.00 |
| DSDNA | activates | gene | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| BAX | activates | gene | 1.00 |
| PI3K | therapeutic_target | gene | 1.00 |
| P53 | regulates | gene | 1.00 |
| EGFR | therapeutic_target | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| TP53 | activates | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| ROS | regulates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| P53 | inhibits | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | inhibits | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| TBK1 | activates | gene | 1.00 |
| MITOPHAGY | activates | gene | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| AGING | associated_with | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| AGING | activates | gene | 1.00 |
| MITOCHONDRIA | associated_with | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| UBIQUITIN | regulates | gene | 1.00 |
| AGING | therapeutic_target | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | associated_with | gene | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| MITOCHONDRIA | activates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| CANCER | expressed_in | gene | 1.00 |
| CANCER | inhibits | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re | 0.581 | neurodegeneration | What are the mechanisms by which gut mic |
| Mitochondrial DNA-Driven AIM2 Inflammasome Activation in Neu | 0.580 | neurodegeneration | What are the mechanisms by which gut mic |
| PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Damage and Su | 0.562 | neurodegeneration | What upstream mechanisms trigger p53 act |
| Senescent Cell Mitochondrial DNA Release | 0.545 | neurodegeneration | Senolytic therapy for age-related neurod |
| Temporal CAG Repeat Stabilization via CRISPR-Mediated DNA Mi | 0.511 | neurodegeneration | CRISPR-based therapeutic approaches for |
| Oligodendrocyte DNA Repair Enhancement Therapy | 0.462 | neurodegeneration | Cell type vulnerability in Alzheimer's D |
| HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor | 0.420 | neurodegeneration | Protein aggregation cross-seeding across |
| Oligodendrocyte DNA Repair Enhancement | 0.378 | neurodegeneration | Cell type vulnerability in Alzheimers Di |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-12 | 0 hypotheses
neurodegeneration | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-08 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 2 |
| Stimuli-responsive nanoplatforms for precision activation of the STING pathway i [PMID:41668757] | ["Bi D", "Yang X", "Wang Y", "Yong J", " | Frontiers in immunology | 2026 | 0 |
| Decoding senescent drivers in Alzheimer's disease: From bench to bedside. [PMID:41344577] | ["Zhou R", "Lin X", "Liao Z", "Lin J", " | Ageing research reviews | 2026 | 0 |
| Mismatch repair MLH complexes make distinct contributions to post-replicative mi [PMID:41648604] | Casazza KM, Williams GM, Johengen L, Kel | bioRxiv | 2026 | 0 |
| DNAJB6: A guardian against neurodegeneration. [PMID:40536953] | Hentze J, Gelman A, Brudek T, Hansen C | Neural regeneration research | 2026 | 0 |
| Overexpression of the ERG oncogene in prostate cancer identifies candidates for [PMID:41632544] | Köcher S, Elsesy ME, Moustafa A, Mohamma | J Clin Invest | 2026 | 0 |
| Genetic variations in base excision repair genes and the risk of developing hepa [PMID:41844453] | Shao B, Yin H, Zhang S, He S, Lu H et al | Cancer Genet | 2026 | 0 |
| Parkinson's disease linked LRRK2 G2019S drives oxidative nuclear DNA damage and [PMID:41889852] | Liu J, Gonzalez-Hunt CP, Richbourg T, Ba | bioRxiv : the preprint server | 2026 | 0 |
| PARG inhibition sequesters nuclear PAR-binding proteins, including XRCC1 and its [PMID:41890038] | Dumoulin I, Lee BJ, Zhang C, Lin X, Wang | bioRxiv | 2026 | 0 |
| Function of HIF-1α in Regulation of Antioxidative Stress of Tribolium castaneum [PMID:41899005] | Wan Z, Li X, Wang Y, Miao S, Chen Z et a | Insects | 2026 | 0 |
| Versatile and sensitive detection of mono- and poly(ADP-ribosyl)ation reveals XR [PMID:41922367] | Dauben H, Mihaljević M, Kolvenbach A, Pa | Nat Commun | 2026 | 0 |
| Role of NEIL1 in genome maintenance. [PMID:40010204] | ["McCullough A", "Minko I", "Luzadder M" | DNA repair | 2025 | 0 |
| Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078] | ["Ranjitha V", "Kumar A", "Kaalappa P"] | Pharmaceutical research | 2025 | 0 |
| Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven imm [PMID:40203808] | ["Lai P", "Liu L", "Bancaro N", "Troiani | Immunity | 2025 | 0 |
| Apheresis for senescence: Targeting the senescence-associated secretory phenotyp [PMID:40651559] | ["Akgun Y"] | Ageing research reviews | 2025 | 0 |
| Methodological influences on circulating cell-free-mitochondrial and nuclear DNA [PMID:40080226] | ["Daubermann C", "Herhaus B", "Neuberger | Molecular biology reports | 2025 | 0 |
| Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflamma [PMID:40902587] | ["Song Z", "Xie X", "Chen Y", "Zhang B", | Immunity | 2025 | 0 |
| Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] | ["Sanadgol N", "Abedi M", "Hashemzaei M" | Journal of nanobiotechnology | 2025 | 0 |
| Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non- [PMID:41271702] | Resnick SJ, Qamar S, Krishna P, Korobeyn | Nature communications | 2025 | 0 |
| Antileukemic potential of methylated indolequinone MAC681 through immunogenic ne [PMID:38704604] | ["Orlikova-Boyer B", "Lorant A", "Gajula | Biomarker research | 2024 | 0 |