gene

GBA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GBA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1489Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

Summary

GBA is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 591 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GBA
Chromosome	1q22.
Function	is a critical gene in the intersection of lysosomal storage disorders and neurodegenerative diseases.
Molecular Weight	60 kDa
Amino Acids	536 aa
Pathways	Amyloid, Autophagy, Autophagy-Lysosomal Pathway, Chaperone, Epigenetic
Ensembl ID	ENSG00000177628
GeneCards	GBA
Human Protein Atlas	GBA
LRRK2	Another Parkinson's disease susceptibility gene with lysosomal dysfunction mechanisms
SNCA	Encodes α-synuclein; GBA mutations promote its aggregation
SMPD1	Acid sphingomyelinase; related lysosomal lipid hydrolase
Gaucher Disease	GBA mutation disease with primary manifestation
Associated Diseases	AD, ALI, ALS, Aging, Alzheimer
Interactions	FUNDC1, AMBRA1, PINK1, BCL2L13, NLRP3, ABCD3
KG Connections	1489 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🧬 3D Structure: GBA — PDB 2V3D Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GBA["GBA"] -->|"causes"| mitochondrial_dysfunction["mitochondrial dysfunction"]
    GBA["GBA"] -.->|"inhibits"| autophagy["autophagy"]
    GBA["GBA"] -.->|"inhibits"| mitophagy["mitophagy"]
    GBA["GBA"] -->|"contributes to"| Parkinson_disease["Parkinson disease"]
    GBA["GBA"] -->|"contributes to"| Parkinson_s_disease["Parkinson's disease"]
    GBA["GBA"] -->|"activates"| Parkinson["Parkinson"]
    Parkinson_1["Parkinson"] -->|"interacts"| GBA["GBA"]
    CAT["CAT"] -->|"interacts"| GBA["GBA"]
    OPTN["OPTN"] -->|"interacts"| GBA["GBA"]
    DNM1L["DNM1L"] -->|"interacts"| GBA["GBA"]
    style GBA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (927)

Target	Relation	Type	Str
Lewy body pathology	associated_with	phenotype	0.98
right pars triangularis volume	causes	brain_region	0.98
Parkinson Disease	risk_factor_for	disease	0.95
GLUCOSYLCERAMIDASE	encodes	enzyme	0.95
GCASE	encodes	enzyme	0.95
Glucocerebrosidase	encodes	enzyme	0.95
Gaucher Disease	causes	disease	0.95
Gaucher's disease	causes	disease	0.95
Parkinson's Disease	risk_factor_for	disease	0.95
Parkinson'S Disease	risk_factor_for	disease	0.95
Glucosylceramide Accumulation	causes	phenotype	0.93
autophagy	inhibits	pathway	0.90
Parkinson disease	contributes_to	disease	0.90
Glucocerebrosides	associated_with	chemical	0.90
Glucocerebrosidase	associated_with	enzyme	0.90
gut-brain axis	participates_in	pathway	0.90
Gaucher disease	causes	disease	0.90
mitochondrial dysfunction	causes	phenotype	0.90
mitophagy	inhibits	pathway	0.90
Parkinson's disease	contributes_to	disease	0.90
LYSOSOMAL DYSFUNCTION	regulates	entity	0.90
oxidative stress response	participates_in	pathway	0.90
Parkinson's disease	risk_factor	disease	0.90
Autophagy-Lysosomal Pathway	regulates	pathway	0.88
Glucosylceramidase Beta 1	activates	protein	0.85
Alpha-Synuclein Neurotoxicity	modulates	phenotype	0.85
α-synuclein neurotoxicity	modulates	phenotype	0.85
lysosomal degradation	involved_in	process	0.85
Als	associated_with	disease	0.85
Parkinson'S Disease	involved_in	disease	0.85
Autophagy	involved_in	process	0.85
putamen volume	regulates	brain_region	0.82
non-manifesting carriers	expressed_in	cell_type	0.80
Lewy body dementia	associated_with	disease	0.80
alpha-synuclein	regulates	protein	0.80
Parkinson	activates	entity	0.80
Microglial Autophagy and Phagocytosis	contributes_to	process	0.75
Parkinson	associated_with	disease	0.75
Parkinson	therapeutic_target	disease	0.75
Dementia	associated_with	disease	0.75
Depression	therapeutic_target	disease	0.75
Als	activates	disease	0.75
REM sleep behavior disorder	associated_with	disease	0.70
glucosylceramidase beta	encodes	protein	0.70
neurodegeneration	associated_with	disease	0.70
neurodegeneration	interacts_with	disease	0.70
neuroinflammation	implicated_in	disease	0.70
lysosomal degradation	regulates	process	0.70
Parkinson	regulates	entity	0.70
Parkinson's disease	associated_with	disease	0.70

Incoming (562)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	gene	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
rs75548401	associated_with	compound	0.92
NEURODEGENERATION	associated_with	gene	0.90
LRRK2	interacts_with	gene	0.85
AMYLOID	associated_with	gene	0.74
MICROGLIA	associated_with	cell_type	0.74
LRRK2	associated_with	gene	0.70
SNCA	associated_with	gene	0.70
Parkinson	interacts_with	entity	0.70
PARKINSON'S DISEASE	therapeutic_target	gene	0.70
PARKINSON'S DISEASE	activates	gene	0.70
ALPHA-SYNUCLEIN	causes	gene	0.70
PARKINSON	associated_with	gene	0.70
PARKINSON	therapeutic_target	gene	0.70
AUTOPHAGY	associated_with	gene	0.66
APOE	associated_with	gene	0.65
APOE	co_discussed	gene	0.65
BIN1	co_discussed	gene	0.65
ACHE	protects_against	gene	0.65
ATP	activates	gene	0.65
FRONTOTEMPORAL DEMENTIA	causes	disease	0.65
NEURONS	produces	cell_type	0.65
LEVODOPA	exacerbates	drug	0.65
DEPRESSION	increases_risk	disease	0.65
DEMENTIA	regulates	disease	0.65
CAT	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
FAM134B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GBA

Understanding Entity Pages

Summary

Wiki Pages (21)

GBA (Redirect)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Novel Therapy Index

Parkinson's Disease

Atypical Parkinsonism

Alpha-Synuclein Pathology

Pathway Diagram

Outgoing (927)

Incoming (562)

Targeting Hypotheses (0)

Mentioning Analyses (3)

Does TFEB activation directly restore mutant GBA enzyme activity or only enhance

GBA-Synuclein Loop Therapeutics for PD

GBA-Synuclein Loop: Therapeutic Strategies for Parkinson's Disease

Related Papers (0)

GBA

Understanding Entity Pages

Summary

Wiki Pages (21)

GBA (Redirect)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Novel Therapy Index

Parkinson's Disease

Atypical Parkinsonism

Alpha-Synuclein Pathology

PD Combination Therapy Matrix

Therapeutics

neuroinflammation

Multiple System Atrophy

PD Cure Roadmap

Mitochondrial Dysfunction in Parkinson's Disease

Synucleinopathy Mechanism

Autophagy Mechanisms

oxidative-stress-comparison

APOC4 — Apolipoprotein C-IV

Mitophagy Pathway in Neurodegeneration

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases

University of Heidelberg

AI and Machine Learning in Neurodegeneration

rankings

Pathway Diagram

Outgoing (927)

Incoming (562)

Targeting Hypotheses (0)

Mentioning Analyses (3)

Does TFEB activation directly restore mutant GBA enzyme activity or only enhance

GBA-Synuclein Loop Therapeutics for PD

GBA-Synuclein Loop: Therapeutic Strategies for Parkinson's Disease

Related Papers (0)