gene

OPRK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OPRK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

OPRK1 encodes the kappa-opioid receptor, a G-protein coupled receptor modulating pain, mood, reward, and neuroinflammation. Implicated in Parkinson's disease, drug addiction, and stress-related neurodegeneration.

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🧬 Gene Info

Gene Symbol	OPRK1
Full Name	Kappa Opioid Receptor
Aliases	KOR, OPRK
Chromosome	8q11.23
Protein Type	Receptor
Function	Dynorphins are the only known endogenous ligands with significant KOR selectivity; beta-endorphin and enkephalins bind primarily to mu and delta receptors[@bruchas2011].
Primary Expression	CNS (striatum, cortex, hippocampus, hypothalamus, spinal cord), peripheral sensory neurons, immune cells
Molecular Weight	48 kDa
Amino Acids	426 aa
Pathways	MAPK pathway, PI3K
UniProt ID	P41145
NCBI Gene ID	4985
GeneCards	OPRK1
Human Protein Atlas	OPRK1
Agonists	Salvinorin A (the active component of Salvia divinorum), U-50488, U-69593, spiradoline, enadoline
Associated Diseases	Parkinson's disease, Alzheimer's disease
Databases	GeneCards HPA STRING

🔮 Predicted Structure: OPRK1 — AlphaFold P41145 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

OPRK1 — Kappa Opioid Receptor

gene · 1627 words

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Pathway Diagram

graph TD
    OPRK1["OPRK1"]
    neurodegeneration["neurodegeneration"]
    OPRK1 -->|"implicated_in"| neurodegeneration
    style OPRK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning OPRK1 in their description or question text

No additional research found