Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about P2Y: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| pain transduction | mediates | process | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Purinergic P2Y12 Inverse Agonist Therapy | 0.480 | neurodegeneration | Synaptic pruning by microglia in early A |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| FTD Microglia Role: Protective vs Destructive Mechanism Study | validation | Neuroinflammation | 0.400 | 0.50 | human | proposed | $2,960,000 |
| TREM2 Agonist Therapy for Parkinson's Disease — Experimental Design | validation | Parkinson's Disease | 0.400 | 0.50 | mouse | proposed | $280,000 |
| Microglial TREM2 Agonist In Vivo Efficacy | validation | Alzheimer's Disease | 0.400 | 0.50 | mouse | proposed | $360,000 |
| Purinergic Signaling Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| s:** - GPR32 knockout in microglia should worsen neuroinflammation if | falsification | Neuroinflammation | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Proposed experiment from debate on Synaptic pruning by microglia in ea | falsification | Neuroinflammation | 0.400 | 0.50 | mouse | proposed | $240,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Beyond Activation: Characterizing Microglial Functional Phenotypes. [PMID:34571885] | Lier J, Streit WJ, Bechmann I | Cells | 2021 | 2 |
| The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting auto [PMID:32160082] | Pi S, Mao L, Chen J, Shi H, Liu Y, Guo X | Autophagy | 2021 | 2 |
| Role of P2Y(12) Receptor in Thrombosis. [PMID:27628007] | Zhang Y, Zhang S, Ding Z | Adv Exp Med Biol | 2017 | 1 |
| P2 purinergic receptors in systemic lupus erythematosus: from experimental findi [PMID:41825304] | Renaudineau Y, Brooks W | Current opinion in immunology | 2026 | 0 |
| The Dual Role of P2RY12: Impact of Polymorphism and Expression on Ischemic Event [PMID:41903930] | Li J, Gong Z, Wang S, Gu J, Wu S, Pang J | Journal of thrombosis and haem | 2026 | 0 |
| Association of P2Y12 Polymorphisms With the Risk of Ischemic Stroke Subtypes. [PMID:41761998] | Wu C, Chen Y, Chen J, Wei X, Zhang Z | Revista de neurologia | 2026 | 0 |
| [Advantageous therapeutic pathways and mechanisms of Jianpi Huogu Formula in tre [PMID:41814722] | Li T, Zhang C, Jia Y, Chen WH, Lin N, Zh | Zhongguo Zhong yao za zhi = Zh | 2026 | 0 |
| Clopidogrel Administration Impairs Neurovascular Unit Recovery and Exacerbates A [PMID:41898413] | Paul M, Paul JW, Hinwood M, Hood RJ, Mar | International journal of molec | 2026 | 0 |
| Pan-cancer T cell atlas links a cellular stress response state to immunotherapy [PMID:37248301] | ["Chu Y", "Dai E", "Li Y", "Han G", "Pei | Nature medicine | 2023 | 0 |
| Immune-related adverse events predict responses to PD-1 blockade immunotherapy i [PMID:33890283] | ["Lu L", "Xing K", "Wei W", "Ling Y", "L | International journal of cance | 2021 | 0 |
| Endogenous TLR2 ligand embedded in the catalytic region of human cysteinyl-tRNA [PMID:32461342] | ["Cho S", "Kim S", "Lee Y", "Song E", "K | Journal for immunotherapy of c | 2020 | 0 |
| Assemblies of Perisomatic GABAergic Neurons in the Developing Barrel Cortex. [PMID:31780328] | ["Modol L", "Bollmann Y", "Tressard T", | Neuron | 2020 | 0 |
| A Unique Microglia Type Associated with Restricting Development of Alzheimer's D [PMID:28602351] | ["Keren-Shaul H", "Spinrad A", "Weiner A | Cell | 2017 | 0 |
| Platelet P2Y12 receptor inhibition by thienopyridines: status and future. [PMID:19678800] | ["Porto I", "Giubilato S", "De Maria G", | Expert opinion on investigatio | 2009 | 0 |
| Pten regulates neuronal arborization and social interaction in mice. [PMID:16675393] | ["Kwon C", "Luikart B", "Powell C", "Zho | Neuron | 2006 | 0 |
| Randomized comparison of prasugrel (CS-747, LY640315), a novel thienopyridine P2 [PMID:15967851] | ["Wiviott S", "Antman E", "Winters K", " | Circulation | 2005 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity