entity

PDGFRβ

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDGFRβ: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections
6Hypotheses
3Analyses
3Outgoing
3Incoming
0Experiments
3Debates

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Outgoing (3)

TargetRelationTypeStr
sPDGFRβectodomain_sheddingprotein0.00
BBB_integritymaintainsprocess0.00
STAT3activatesprotein0.50

Incoming (3)

SourceRelationTypeStr
mir320regulatesRNA0.00
PDGFRBencodesgene0.95
PDGF-BBactivatesprotein0.25

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Circulating Soluble PDGFRβ Reflects Pericyte Loss and Preced 0.745 - What blood-brain barrier permeability ch
Soluble PDGFRβ as a Peripheral Indicator of Pericyte-Mediate 0.705 - What blood-brain barrier permeability ch
Integrated Blood Panel of sPDGFRβ, sTM, and Circulating micr 0.625 - What blood-brain barrier permeability ch
Circulating Soluble PDGFRβ Reflects Pericyte Loss and Preced 0.625 - What blood-brain barrier permeability ch
PDGF-BB/PDGFRβ/STAT3 Paracrine Signaling Axis Mediates Aβ-In 0.618 neurodegeneration How do perivascular cells specifically r
Elevated Circulating sPDGFRβ Reflects Early Pericyte Loss Pr 0.600 - What blood-brain barrier permeability ch

Mentioning Analyses (3)

Scientific analyses that reference this entity

What blood-brain barrier permeability changes serve as early biomarkers for neur

neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.745

What blood-brain barrier permeability changes serve as early biomarkers for neur

neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.735

How do perivascular cells specifically recognize and respond to amyloid-β to upr

neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.618

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (3)

Multi-agent debates referencing this entity

What blood-brain barrier permeability changes serve as early biomarkers for neur

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

What blood-brain barrier permeability changes serve as early biomarkers for neur

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

The abstract indicates SPP1 upregulation occurs in perivascular macrophages and

closed · Rounds: 4 · Score: 0.67 · 2026-04-22

Related Research

Hypotheses and analyses mentioning PDGFRβ in their description or question text

Elevated Circulating sPDGFRβ Reflects Early Pericyte Loss Preceding Neurodegener

Score: 0.600 · unknown disease · 2026-04-26

Pericyte degeneration in neurodegeneration leads to proteolytic shedding of the PDGFRβ ectodomain. Soluble PDGFRβ (sPDGF