Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BBB_integrity: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| PDGFRβ | maintains | protein | 0.00 |
| occludin | maintains | protein | 0.80 |
| pericyte_function | preserves | pathway | 0.80 |
| MERTK | decreases_risk | gene | 0.70 |
| TAM agonism | associated_with | phenotype | 0.70 |
| pericyte dysfunction | associated_with | cell_type | 0.70 |
| TJP1 | protective_against | protein | 0.70 |
| OCLN | protective_against | protein | 0.70 |
| CLDN5 | protective_against | protein | 0.70 |
| S100B | disrupts | protein | 0.65 |
| ANG1 enhancement | enhances | drug | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| BBB Integrity Loss Defines Absolute Therapeutic Window Closu | 0.660 | neurodegeneration | What is the optimal therapeutic window f |
| Vascular and Perivascular Cell Type Vulnerability: BBB Integ | 0.566 | neurodegeneration | Cell type vulnerability debate in Alzhei |
| CSF p-tau217 Normalization Requires Intact Synaptic Function | 0.515 | neurodegeneration | - |
| HBOT at 1.5 ATA for 90 days restores BBB integrity by upregu | 0.460 | neurodegeneration | What are the optimal oxygen pressure, du |
| HTR2A-Mediated MMP-9 Suppression Preserves BBB Integrity at | 0.425 | - | What is the minimum effective dose of tr |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.735
neurodegeneration | 2026-04-16 | 14 hypotheses Top: 0.806
neuroinflammation | 2026-04-13 | 0 hypotheses
neurodegeneration | 2026-04-04 | 5 hypotheses Top: 0.661
neurodegeneration | 2026-04-03 | 19 hypotheses Top: 0.891
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.57 · 2026-04-28
closed · Rounds: 4 · Score: 0.12 · 2026-04-27
closed · Rounds: 4 · Score: 0.42 · 2026-04-27
closed · Rounds: 4 · Score: 0.48 · 2026-04-27
closed · Rounds: 4 · Score: 0.47 · 2026-04-27
closed · Rounds: 4 · Score: 0.21 · 2026-04-27
closed · Rounds: 4 · Score: 0.52 · 2026-04-27
closed · Rounds: 4 · Score: 0.72 · 2026-04-27
closed · Rounds: 4 · Score: 1.00 · 2026-04-26
closed · Rounds: 4 · Score: 0.76 · 2026-04-23
Hypotheses and analyses mentioning BBB_integrity in their description or question text
No additional research found