gene

PDGFRB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDGFRB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

587Connections

2Hypotheses

3Analyses

50Outgoing

50Incoming

Summary

PDGFRB is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, biomarker for. Associated with ALS, Aging, Als. Connected to 299 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PDGFRB
Full Name	Platelet Derived Growth Factor Receptor Beta
Chromosome	5q32
Protein Type	Kinase
Target Class	Kinase
Function	PDGFRB encodes the beta chain of the platelet-derived growth factor receptor, a receptor tyrosine kinase that binds PDGF-BB and PDGF-AB.
Mechanism of Action	Small molecule inhibitor of receptor tyrosine kinase activity
Druggability	Medium (0.50)
Clinical Stage	Approved
Pathways	PI3K, MAPK
UniProt ID	E5RII0
Ensembl ID	ENSG00000113721
OMIM	173410
GeneCards	PDGFRB
Human Protein Atlas	PDGFRB
Associated Diseases	ALS, Aging, Alzheimers_disease, Basal Ganglia Calcifications, Cardiac
Known Drugs/Compounds	tyrosine_kinase_inhibitor, dasatinib
Interactions	ANGPT1, STAT5, VEGFB, STING, CSF1R, SRC
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Vascular mural cell degeneration precedes and exac Pericyte Contractility Reset via Selective PDGFR-β
KG Connections	587 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PDGFRB — AlphaFold E5RII0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PDGFRB["PDGFRB"] -->|"associated"| neurodegeneration["neurodegeneration"]
    PDGFRB["PDGFRB"] -->|"interacts"| ANGPT1["ANGPT1"]
    PDGFRB["PDGFRB"] -->|"co discussed"| TGFB1["TGFB1"]
    ANGPT1_1["ANGPT1"] -->|"interacts"| PDGFRB["PDGFRB"]
    AQP1["AQP1"] -->|"co discussed"| PDGFRB["PDGFRB"]
    KCNK2["KCNK2"] -->|"co discussed"| PDGFRB["PDGFRB"]
    GJA1["GJA1"] -->|"co discussed"| PDGFRB["PDGFRB"]
    style PDGFRB fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (343)

Target	Relation	Type	Str
Primary Familial Brain Calcification	associated_with	disease	0.95
Primary Familial Brain Calcification	causes	disease	0.95
Basal Ganglia Calcifications	causes	disease	0.93
Fahr's Disease	risk_factor_for	disease	0.90
Cerebrovascular Integrity	biomarker_for	process	0.85
neurovascular unit	modulates	cell_type	0.80
pericyte_function	maintains	pathway	0.80
Ph_like_ALL	associated_with	disease	0.72
myofibroblasts	expressed_in	cell_type	0.72
liver_fibrosis	activates	disease	0.72
hepatic_stellate_cells	activates	cell_type	0.72
oxidative stress response	participates_in	pathway	0.70
Arthritis	activates	disease	0.65
Als	activates	disease	0.65
Cancer	activates	disease	0.65
Ms	activates	disease	0.65
Tumor	activates	disease	0.65
Aging	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Als	associated_with	disease	0.65
Leukemia	activates	disease	0.65
Ms	regulates	disease	0.65
Cardiac	associated_with	disease	0.65
Fibrosis	activates	disease	0.65
Ms	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Senescence	therapeutic_target	disease	0.65
Leukemia	therapeutic_target	disease	0.65
Ms	inhibits	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Inflammation	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Ms	interacts_with	disease	0.65
Als	regulates	disease	0.65
Senescence	activates	disease	0.65
Inflammation	activates	disease	0.65
Tumor	regulates	disease	0.65
Cardiovascular	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	contributes_to	disease	0.65
Carcinoma	activates	disease	0.65
Aging	activates	disease	0.65
Inflammation	expressed_in	disease	0.65
ALS	activates	disease	0.65

Incoming (244)

Source	Relation	Type	Str
h-35f04e1b	targets_gene	hypothesis	0.90
h-73e4340b	targets_gene	hypothesis	0.90
h_seaad_005	targets_gene	hypothesis	0.90
STING	upregulates	protein	0.85
h-35f04e1b	targets	hypothesis	0.80
h-73e4340b	targets	hypothesis	0.80
PDGFD	interacts_with	protein	0.72
tyrosine_kinase_inhibitor	inhibits	drug	0.72
PDGF_BB	activates	protein	0.72
dasatinib	inhibits	drug	0.72
PDGF	activates	protein	0.72
CRLF2	activates	gene	0.70
MFSD2A	inhibits	gene	0.65
BMP2	activates	gene	0.60
VEGF	activates	gene	0.60
FGF2	activates	gene	0.60
ANGPT1	activates	gene	0.60
CD8	activates	gene	0.60
JUN	associated_with	gene	0.60
JAM2	associated_with	gene	0.60
TYK2	contributes_to	gene	0.60
PTK2B	contributes_to	gene	0.60
IL7R	contributes_to	gene	0.60
JAK2	activates	gene	0.60
IL9	biomarker_for	gene	0.60
VEGFA	associated_with	gene	0.60
IL4	biomarker_for	gene	0.60
FGF2	biomarker_for	gene	0.60
GFAP	biomarker_for	gene	0.60
NPTX1	associated_with	gene	0.60
CHIT1	associated_with	gene	0.60
MDH1	biomarker_for	gene	0.60
GLI1	regulates	gene	0.60
VEGFB	activates	gene	0.60
STING	activates	gene	0.60
PDGFB	associated_with	gene	0.60
NTRK3	contributes_to	gene	0.60
LMNA	therapeutic_target	gene	0.60
IGF1	activates	gene	0.60
PI3K	activates	gene	0.60
SQSTM1	biomarker_for	gene	0.60
NEFL	biomarker_for	gene	0.60
CHI3L1	associated_with	gene	0.60
BDNF	biomarker_for	gene	0.60
PDGFRA	interacts_with	gene	0.60
ANGPT1	associated_with	gene	0.60
PDGFB	regulates	gene	0.60
MYC	activates	gene	0.60
AKT	activates	gene	0.60
EGR1	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Vascular mural cell degeneration precedes and exacerbates pa	0.520	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
Pericyte Contractility Reset via Selective PDGFR-β Agonism	0.443	neurodegeneration	Perivascular spaces and glymphatic clear

Mentioning Analyses (3)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic [PMID:40848726]	Zhao S, Li R, Xia Y, Wang X, Liu Z, Chu	Cell Stem Cell	2025	1
Neurovascular unit, neuroinflammation and neurodegeneration markers in brain dis [PMID:39526043]	Kempuraj D, Dourvetakis KD, Cohen J, Val	Front Cell Neurosci	2024	1
The Genetics of Primary Familial Brain Calcification: A Literature Review. [PMID:37446066]	Chen SY, Ho CJ, Lu YT, Lin CH, Lan MY, T	Int J Mol Sci	2023	1
Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmon [PMID:35257044]	Calvier L, Herz J, Hansmann G	JACC Basic Transl Sci	2022	1
Decoding myofibroblast origins in human kidney fibrosis. [PMID:33176333]	Kuppe C, Ibrahim MM, Kranz J, Zhang X, Z	Nature	2021	1
APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. [PMID:32376954]	Montagne A, Nation DA, Sagare AP, Barisa	Nature	2020	1
Pathophysiology of Primary Familial Brain Calcification. [PMID:41212990]	Keller A	Annual review of physiology	2026	0
A FZD4/LRP5 agonist restores pericyte coverage and vascular integrity by increas [PMID:41890033]	Levey J, Howe M, Douglas K, Odame E, Raj	bioRxiv : the preprint server	2026	0
Immunological mechanisms and therapeutic approaches in pulmonary fibrosis. [PMID:41951242]	Nell LM, Hendriks RW, Wijsenbeek MS, Cor	Eur Respir Rev	2026	0
Nano-Enabled Fluorescence Switching: A Novel Strategy for PDGFRβ Detection and T [PMID:41884335]	Fu X, Fan J, Chen H, Zheng Y, Liu Y, Zha	Research (Washington, D.C.)	2026	0
Loss of Pericyte Exacerbates Alzheimer's Disease-Associated Retinal Pathology. [PMID:41814129]	Hai-Chao C, Fu-Lin G, Jia-Xin C, Yi-Shu	Clinical & experimental ophtha	2026	0
Central nervous system pericytes express soluble ST2 in inflammation and injury. [PMID:41857656]	Jansson D, Highet B, Li S, Stevenson TJ,	Molecular brain	2026	0
Astrocyte-Glioblastoma Stem Cell Interactions via Extracellular Vesicles Contrib [PMID:41712235]	Shirai Y, Tsuda M, Wang L, Oda Y, Sugizn	Pathology international	2026	0
Therapeutic effects of the n-butanol extract of Potentilla freyniana Bornm. in h [PMID:40902811]	Wang Y, Zhang Z, Cao L, Huang S, Huang X	J Ethnopharmacol	2026	0
Based on network pharmacology and experiments to investigate the inhibitory effe [PMID:41308710]	Yang X, Xiao JH, Li X, Liu RM, Yuan Q	J Ethnopharmacol	2026	0
Novel insights into meningioma brain invasion with spatial transcriptomic profil [PMID:41486296]	Maier AD, Laurentiussen CO, Michaelsen S	Acta Neuropathol Commun	2026	0
Brain vascular stability relies on PAK2-cilia-PDGF-BB-HSPGs on basolateral side [PMID:41490797]	Prabhudesai S, Thirugnanam K, Song X, Ya	Life Sci Alliance	2026	0
Plasma platelet-derived growth factor receptor-β decrease correlates with blood- [PMID:41530860]	Li J, Li A, Ye C, Zhang L, Jiang M et al	Mol Neurodegener	2026	0
FOXF2 regulates pericyte-endothelial signaling required for vascular homeostasis [PMID:41680210]	Sun F, Zhao Y, Do J, Cheng P, Li E et al	Nat Commun	2026	0
Molecular Characterization of Biphasic Follicular Dendritic Cell Sarcoma. [PMID:41943444]	Hassan F, Boyle T, Palma J, Li J, Hussai	Appl Immunohistochem Mol Morph	2026	0

PDGFRB

Understanding Entity Pages

Summary

Wiki Pages (21)

PDGFRB — Platelet Derived Growth Factor Receptor Beta

FGF23 — Fibroblast Growth Factor 23

Biomarkers of Alzheimer Disease

Biomarker-Therapeutic Development Nexus

Biomarkers in Neurodegeneration

Biomarkers for Parkinson's Disease

Pathway Diagram

Outgoing (343)

Incoming (244)

Targeting Hypotheses (2)

Mentioning Analyses (3)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Perivascular spaces and glymphatic clearance failure in AD

Digital biomarkers and AI-driven early detection of neurodegeneration

Related Papers (20)

PDGFRB

Understanding Entity Pages

Summary

Wiki Pages (21)

PDGFRB — Platelet Derived Growth Factor Receptor Beta

FGF23 — Fibroblast Growth Factor 23

Biomarkers of Alzheimer Disease

Biomarker-Therapeutic Development Nexus

Biomarkers in Neurodegeneration

Biomarkers for Parkinson's Disease

ASC (PYCARD)

Neurovascular Unit Dysfunction Hypothesis in Parkinson's Disease

Brain Pericytes in Neurodegeneration

Biomarkers for Corticobasal Degeneration

Biomarkers for Progressive Supranuclear Palsy

Biomarker Discovery Framework for Neurodegenerative Diseases

DOCK1 Gene

slc22a5

NPTX1 Protein

Biomarkers in Parkinsonian Syndromes (NCT06501469)

YWHAH Gene — 14-3-3 Eta (η) Protein

pericyte-dysfunction

Biomarker-Based Classification of Corticobasal Syndrome

CCR7 Gene (C-C Chemokine Receptor Type 7)

vascular-dementia-treatment

Pathway Diagram

Outgoing (343)

Incoming (244)

Targeting Hypotheses (2)

Mentioning Analyses (3)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Perivascular spaces and glymphatic clearance failure in AD

Digital biomarkers and AI-driven early detection of neurodegeneration

Related Papers (20)