Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PEX19: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PEX19 encodes peroxin-19, the essential cytosolic chaperone and import receptor for peroxisomal membrane proteins, critical for peroxisome biogenesis
| Gene Symbol | PEX19 |
| Full Name | Peroxisome Biogenesis Factor 19 |
| Chromosome | 1q23.2 |
| Protein Family | PEX proteins, peroxisomal import chaperones |
| Function | is a cytosolic protein with multiple functional domains |
| Subcellular Localization | Cytosol (primary), peroxisomal membrane (transient) |
| Amino Acids | 326 aa |
| UniProt ID | P40818 |
| NCBI Gene ID | 5294 |
| Ensembl ID | ENSG00000162755 |
| OMIM | 603419 |
| GeneCards | PEX19 |
| Human Protein Atlas | PEX19 |
| Encoded Protein | Peroxin-19 |
| Protein Length | 326 amino acids |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | PEX3 |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
PEX19["PEX19"]
PEX3["PEX3"]
MITOCHONDRIA["MITOCHONDRIA"]
neurodegeneration["neurodegeneration"]
PEX19 -->|"interacts with"| PEX3
PEX19 -->|"expressed in"| PEX3
MITOCHONDRIA -->|"expressed in"| PEX19
PEX19 -->|"implicated in"| neurodegeneration
style PEX19 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
style PEX3 fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
style MITOCHONDRIA fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
style neurodegeneration fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff| Source | Relation | Type | Str |
|---|---|---|---|
| MITOCHONDRIA | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity