PEX3

Understanding Entity Pages

This page aggregates everything SciDEX knows about PEX3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Page for PEX3 Gene - Peroxisome Biogenesis Factor 3

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flowchart TD
    PEX3["PEX3<br/>Peroxisome Biogenesis<br/>Factor 3"]
    
    SQSTM1["SQSTM1/p62<br/>Autophagy Receptor"]
    LC3["LC3<br/>Autophagy Marker"]
    RB1CC1["RB1CC1/FIP200<br/>Autophagy Initiation"]
    
    PARKIN["PARKIN<br/>E3 Ubiquitin Ligase"]
    SNCA["SNCA<br/>alpha-Synuclein"]
    SNCAIP["SNCAIP<br/>Synphilin-1"]
    
    MFN1["MFN1<br/>Mitofusin 1<br/>Mitochondrial Fusion"]
    BCL2["BCL2<br/>Anti-apoptotic<br/>Protein"]
    
    ERN1["ERN1/IRE1alpha<br/>ER Stress<br/>Sensor"]
    FAM134B["FAM134B<br/>ER-phagy<br/>Receptor"]
    
    ATM["ATM<br/>DNA Damage<br/>Response"]
    STING1["STING1<br/>Innate Immunity<br/>Signaling"]
    
    PD["Parkinson's<br/>Disease"]
    AD["Alzheimer's<br/>Disease"]
    ALS["Amyotrophic<br/>Lateral Sclerosis"]
    FTD["Frontotemporal<br/>Dementia"]
    
    PEX3 --|"regulates"|--> SQSTM1
    SQSTM1 --|"binds"|--> LC3
    PEX3 --|"interacts"|--> RB1CC1
    
    PEX3 --|"interacts"|--> PARKIN
    PARKIN --|"ubiquitinates"|--> SNCA
    PEX3 --|"interacts"|--> SNCAIP
    SNCA --|"aggregates"|--> PD
    
    PEX3 --|"regulates"|--> MFN1
    PEX3 --|"interacts"|--> BCL2
    MFN1 --|"maintains"|--> BCL2
    
    PEX3 --|"responds_to"|--> ERN1
    PEX3 --|"interacts"|--> FAM134B
    ERN1 --|"activates"|--> FAM134B
    
    PEX3 --|"interacts"|--> ATM
    PEX3 --|"modulates"|--> STING1
    ATM --|"triggers"|--> STING1
    
    SQSTM1 --|"dysfunction"|--> AD
    PARKIN --|"mutations"|--> PD
    ERN1 --|"stress_response"|--> ALS
    ATM --|"damage_response"|--> FTD
    
    style PEX3 fill:#006494
    style SQSTM1 fill:#4a1a6b
    style LC3 fill:#4a1a6b
    style PARKIN fill:#4a1a6b
    style BCL2 fill:#1b5e20
    style MFN1 fill:#1b5e20
    style ERN1 fill:#ef5350
    style ATM 填:#ef5350
    style PD fill:#5d4400
    style AD fill:#5d4400
    style ALS fill:#5d4400
    style FTD fill:#5d4400