Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PI3K-Akt Signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| FOXO1 | regulates | gene | 0.85 |
| Parkinson'S Disease | associated_with | disease | 0.85 |
| Cell Cycle Regulation | regulates | process | 0.80 |
| Alzheimer's Disease | involved_in | disease | 0.80 |
| Parkinson's Disease | associated_with | disease | 0.75 |
| neuroprotection | protective_against | phenotype | 0.70 |
| Parkinson's Disease | upregulates | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Up-Regulated Mrnas | involved_in | biomarker | 0.90 |
| 22729224 | has central role in | paper | 0.90 |
| 22729224 | plays central role in | paper | 0.90 |
| TREM2 | activates | protein | 0.90 |
| NTN1 EC-EXO | activates | compound | 0.90 |
| 32853409 | mediates | paper | 0.90 |
| FOXO1 | mediates | gene | 0.85 |
| Up-Regulated Demrnas | enriched_in | gene_set | 0.80 |
| AKT1 | part_of | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
molecular biology | 2026-04-12 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning PI3K-Akt Signaling in their description or question text
No additional research found