Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NEUROPROTECTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | NEUROPROTECTION |
| Summary | Page for Neuroprotective Microglia |
| Related Diseases | NEURODEGENERATION |
| Linked Hypotheses | 4 hypotheses |
Knowledge base pages for this entity
graph TD
NEUROPROTECTION["NEUROPROTECTION"]
style NEUROPROTECTION fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
NEUROPROTECTION -.->|"protects against"| Glaucoma["Glaucoma"]
NEUROPROTECTION -.->|"protects against"| Neurodegeneration["Neurodegeneration"]
NEUROPROTECTION -.->|"protects against"| Axonal_Damage(Axonal Damage)
NEUROPROTECTION -.->|"protects against"| major_depressive_disorder["major depressive disorder"]
NEUROPROTECTION -.->|"inhibits"| NEURODEGENERATION(NEURODEGENERATION)
NEUROPROTECTION -.->|"protects against"| PPAR["PPAR"]
NEUROPROTECTION -.->|"protects against"| VDR["VDR"]
NEUROPROTECTION -.->|"protects against"| PARKIN["PARKIN"]
NEUROPROTECTION -->|"activates"| NRF2["NRF2"]
Connexin43_Hemichannel_Blockad["Connexin43 Hemichannel Blockade"] -->|"mediates"| NEUROPROTECTION
MT1([MT1]) -->|"involved_in"| NEUROPROTECTION
MT2([MT2]) -->|"involved_in"| NEUROPROTECTION
Tudca["Tudca"] -->|"mediates"| NEUROPROTECTION
AKT([AKT]) -->|"involved_in"| NEUROPROTECTION
METALLOTHIONEIN([METALLOTHIONEIN]) -->|"mediates"| NEUROPROTECTION
METALLOTHIONEIN_I_II([METALLOTHIONEIN-I+II]) -->|"involved_in"| NEUROPROTECTION
PPARG["PPARG"] -->|"mediates"| NEUROPROTECTION
BDNF_TrkB_signaling["BDNF/TrkB signaling"] -->|"promotes"| NEUROPROTECTION
microglial_APOE4_deletion["microglial APOE4 deletion"] -->|"promotes"| NEUROPROTECTION| Target | Relation | Type | Str |
|---|---|---|---|
| NEURODEGENERATION | inhibits | phenotype | 0.64 |
| PPAR | protects_against | entity | 0.60 |
| PPAR | activates | entity | 0.60 |
| VDR | protects_against | entity | 0.60 |
| PARKIN | protects_against | entity | 0.60 |
| NRF2 | activates | entity | 0.60 |
| PI3K | activates | entity | 0.60 |
| SLC7A11 | activates | entity | 0.60 |
| STROKE | protects_against | entity | 0.60 |
| NLGN3 | activates | entity | 0.60 |
| STROKE | biomarker_for | entity | 0.60 |
| NRF2 | inhibits | entity | 0.60 |
| SLC7A11 | inhibits | entity | 0.60 |
| STROKE | inhibits | entity | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PPAR | protects_against | entity | 0.60 |
| PPAR | activates | entity | 0.60 |
| JUN | protects_against | entity | 0.60 |
| GLAUCOMA | regulates | entity | 0.60 |
| LOX | protects_against | entity | 0.60 |
| AMPK | protects_against | entity | 0.60 |
| APOE | regulates | entity | 0.60 |
| NEURODEGENERATION | regulates | entity | 0.60 |
| AKT | activates | entity | 0.60 |
| GPX4 | activates | entity | 0.60 |
| NEURODEGENERATION | activates | entity | 0.60 |
| NEUROINFLAMMATION | activates | entity | 0.60 |
| NEURODEGENERATION | protects_against | entity | 0.60 |
| GLAUCOMA | protects_against | entity | 0.60 |
| MTOR | protects_against | entity | 0.60 |
| NEUROINFLAMMATION | protects_against | entity | 0.60 |
| NEURODEGENERATION | phosphorylates | entity | 0.60 |
| GPX4 | inhibits | entity | 0.60 |
| REACTIVE_GLIOSIS | regulates | phenotype | 0.56 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| DAPK1 Inhibition as Dual-Mechanism Neuroprotection Against T | 0.579 | neurodegeneration | Should microtubule-stabilizing drugs be |
| Ferroptosis Inhibition for α-Synuclein Neuroprotection | 0.548 | neurodegeneration | Gene expression changes in aging mouse b |
| Mitochondrial Biogenesis Rate as a Dynamic Biomarker of Neur | 0.435 | translational neuroscience | Which metabolic biomarkers can distingui |
| Microbiome-Derived Tryptophan Metabolite Neuroprotection | 0.408 | neurodegeneration | What are the mechanisms by which gut mic |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.467
neurodegeneration | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-06 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Targeting the SCP2/HSPB1 Axis: A Novel Mechanism Underlying Ferroptosis Regulati [PMID:40993092] | Jiang H, Hu W, Yuan L | Tohoku J Exp Med | 2026 | 0 |
| GPX4 promotes optic nerve regeneration and retinal ganglion cell neuroprotection [PMID:41485051] | Yang M, Bian F, Feng X, Li L, Huang H et | Mol Ther | 2026 | 0 |
| Extracellular GPX4 impairs antitumor immunity via dendritic ZP3 receptors. [PMID:41494530] | Liu J, Cai X, Lin J, Zhang Z, Zhou Q et | Cell | 2026 | 0 |
| Aging at the Crossroads of Cuproptosis and Ferroptosis: From Molecular Pathways [PMID:41516398] | Gromadzka G, Tarnacka B, Cieślik M | Int J Mol Sci | 2026 | 0 |
| Ferroptosis in neurological diseases: moving towards therapeutic intervention. [PMID:41554903] | Tuo QZ, Bush AI, Lei P | Mol Psychiatry | 2026 | 0 |
| Fin(e)-tuning ferroptosis. [PMID:41576911] | Szylo KJ, Dixon SJ | Mol Cell | 2026 | 0 |
| GPX4-dependent ferroptosis governs ILC2 homeostasis and colitis progression. [PMID:41663525] | Liu G, Wang Y, Huang H, Wang J, Yang J e | Cell Mol Immunol | 2026 | 0 |
| A GPX1-OSBPL8 axis mediates noncanonical in vivo ferroptosis and cancer growth s [PMID:41720096] | Xia Z, Yang X, Samovich SN, Tyurina YY, | Cell | 2026 | 0 |
| The crossroads of inflammation and oxidative stress: A review of the interplay b [PMID:41722697] | Park WH | Pharmacol Res | 2026 | 0 |
| Ferroptosis in Cerebral Ischemia/Reperfusion Injury: Mechanistic Drivers and The [PMID:41738060] | Song C, Liu Z, Tang J, Huang Y | Neuropsychiatr Dis Treat | 2026 | 0 |
| Decoding GPX4 regulation in ferroptosis: mechanisms and therapeutic implications [PMID:41826143] | Chen X | Trends Mol Med | 2026 | 0 |
| 4-Octyl itaconate attenuates radiation-induced intestinal injury associated with [PMID:41936917] | Zhang S, Yue T, Jin P, Zhang X, Huo Q et | Free Radic Biol Med | 2026 | 0 |
| Di-2-ethylhexylphthalate-induced miR155-5P promotes placental ferroptosis. [PMID:41937013] | Gu X, Sun F, Li Y, Yang S, Li Y | Int J Biol Macromol | 2026 | 0 |
| Co-Delivery of Ferrostatin-1 and M2 Macrophage-Derived Exosomal Signals via Engi [PMID:41944411] | Hao W, Sun N, Xue R, Chang J, Pang X et | ACS Appl Mater Interfaces | 2026 | 0 |
| Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell [PMID:41945797] | Zhang Y, Wang X, Wu Y, Liu L, Nuerlan G | Adv Sci (Weinh) | 2026 | 0 |
| Ferroptosis-related mechanisms in prion diseases provide insights into neurodege [PMID:41945998] | Zayed M, Tayara H, Jeong BH | Redox Biol | 2026 | 0 |
| [The Chinese medicine Gandouling attenuates brain injury in hepatolenticular deg [PMID:41946579] | Wu K, Wang N, Zhao D, Wei W, Zhang W et | Zhejiang Da Xue Xue Bao Yi Xue | 2026 | 0 |
| Isorhamnetin-preconditioned MSC-derived exosomes restore ovarian function by inh [PMID:41947243] | Zhang Q, Yu J, Zheng Y, Jiang J, Zheng L | Stem Cell Res Ther | 2026 | 0 |
| NOX4 mediates ferroptosis through oxidative stress in diabetic keratopathy. [PMID:41951167] | Wang X, Wang Y, Zhao X, Yu X, Qu Y et al | Exp Eye Res | 2026 | 0 |
| Targeting NDUFS4 Disrupts Oxidative Phosphorylation and Induces Ferroptosis in O [PMID:41954274] | Schaaf ZA, Ning S, Leslie AR, Sharifi M, | Mol Cancer Ther | 2026 | 0 |