gene

FOXO1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FOXO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1293Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

Forkhead Box O1 transcription factor - a key regulator of cellular stress response, metabolism, and neuronal survival in neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	FOXO1
Full Name	Forkhead Box O1
Aliases	Forkhead Box O1 transcription factor
Chromosome	13q14.11
Protein Type	Transcription Factor
Target Class	Transcription Factor
Function	It functions as both an activator and repressor depending on cellular context and interacting partners.
Mechanism of Action	Small molecule modulation of protein-DNA interactions or cofactor binding
Druggability	Medium (0.55)
Clinical Stage	Phase I
Molecular Weight	70 kDa
Amino Acids	655 aa
Exons	4 coding exons
Pathways	PI3K
UniProt ID	Q12778
NCBI Gene ID	2308
Ensembl ID	ENSG00000150907
OMIM	136351
GeneCards	FOXO1
Human Protein Atlas	FOXO1
Associated Diseases	ALS, Aging, Alzheimer, Amyotrophic Lateral Sclerosis, Cancer
Known Drugs/Compounds	RESVERATROL, RAPAMYCIN, Epigallocatechin gallate, Cinobufagin, resveratrol, SDHHQ
Interactions	CCL4, NR1H3, MAP3K5, SREBF2, NFE2L2, C1Q
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Transcriptional Autophagy-Lysosome Coupling
KG Connections	1291 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure: FOXO1 — PDB 3CO6 Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FOXO1["FOXO1"] -->|"Regulates"| LC3["LC3"]
    FOXO1["FOXO1"] -->|"Associated With"| neurodegeneration["neurodegeneration"]
    FOXO1["FOXO1"] -->|"Activates"| Ms["Ms"]
    FOXO1["FOXO1"] -->|"Activates"| Inflammation["Inflammation"]
    FOXO1["FOXO1"] -->|"Activates"| Fibrosis["Fibrosis"]
    FOXO1["FOXO1"] -->|"Activates"| Cancer["Cancer"]
    FOXO1["FOXO1"] -->|"Associated With"| Als["Als"]
    FOXO1["FOXO1"] -->|"Associated With"| Aging["Aging"]
    h_ae1b2beb["h-ae1b2beb"] -->|"Targets Gene"| FOXO1["FOXO1"]
    BAX["BAX"] -->|"Associated With"| FOXO1["FOXO1"]
    EHMT2["EHMT2"] -->|"Associated With"| FOXO1["FOXO1"]
    JUN["JUN"] -->|"Inhibits"| FOXO1["FOXO1"]
    SOD2["SOD2"] -->|"Activates"| FOXO1["FOXO1"]
    style FOXO1 fill:#8d4900,color:#e0e0e0
    style LC3 fill:#8d4900,color:#e0e0e0
    style neurodegeneration fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Inflammation fill:#b71c1c,color:#e0e0e0
    style Fibrosis fill:#b71c1c,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Aging fill:#b71c1c,color:#e0e0e0
    style h_ae1b2beb fill:#607D8B,color:#e0e0e0
    style BAX fill:#8d4900,color:#e0e0e0
    style EHMT2 fill:#8d4900,color:#e0e0e0
    style JUN fill:#8d4900,color:#e0e0e0
    style SOD2 fill:#8d4900,color:#e0e0e0

Outgoing (889)

Target	Relation	Type	Str
Als	activates	disease	1.00
Liver Fibrosis	protects_against	disease	0.95
Hepatocytes	expressed_in	cell_type	0.95
hepatocyte apoptosis	promotes	process	0.95
Myogenesis	regulates	process	0.95
Amyotrophic Lateral Sclerosis	mediates	disease	0.95
ALS	mediates	disease	0.95
TGFB1	upregulates	gene	0.92
Myogenesis	inhibits	process	0.92
Tgfb1 Expression	regulates	process	0.91
CCL4-induced Liver Injury	protects_against	disease	0.90
Liver Fibrosis	regulates	disease	0.90
Hepatic Inflammation	regulates	process	0.90
Hepatic Inflammation	promotes	process	0.90
Hepatic Stellate Cell Activation	promotes	process	0.90
TGFB1	mediates	protein	0.90
GH1	upregulates	gene	0.90
SOD2	upregulates	gene	0.90
CAT	upregulates	gene	0.90
Glucose Metabolism	regulates	process	0.90
Hepatocyte	expressed_in	cell_type	0.90
Reactive Oxygen Species	regulates	process	0.90
AKT	activates	gene	0.90
Ccl4-Induced Liver Injury	contributes_to	phenotype	0.88
Energy Homeostasis	regulates	process	0.88
Motor Nerve Terminal Dysfunction	inhibits	phenotype	0.88
Hsc Activation	modulates	process	0.87
Cell Proliferation	regulates	process	0.85
Pi3K-Akt Signaling	mediates	pathway	0.85
Glucose Oxidation	regulates	process	0.85
Motor Abnormalities	inhibits	phenotype	0.85
glycogen synthesis	regulates	process	0.85
GH1	binds	gene	0.85
Inflammation	activates	disease	0.85
Cancer	activates	disease	0.85
Diabetes	regulates	disease	0.85
Cancer	regulates	disease	0.85
Tumor	activates	disease	0.85
TGF-β1	regulates	protein	0.85
Inflammation	inhibits	process	0.85
apoptosis	promotes	process	0.85
Non-Alcoholic Fatty Liver Disease	regulates	disease	0.82
OPTN	regulates	gene	0.81
Cell Migration	regulates	process	0.80
Cell Invasion	regulates	process	0.80
liver fibrosis	prevents	disease	0.80
cell proliferation	suppresses	process	0.80
antioxidant production	promotes	process	0.80
Antioxidant Production	promotes	process	0.80
ATG	regulates	gene	0.80

Incoming (404)

Source	Relation	Type	Str
TAZ	activates	gene	0.95
PI3K/AKT1	inhibits	pathway	0.90
SDHHQ	modulates	drug	0.90
cAMP/PKA signaling pathway	upregulates	pathway	0.90
h-ae1b2beb	targets_gene	hypothesis	0.90
Carbon Tetrachloride	upregulates	compound	0.88
PI3K-Akt Signaling	regulates	pathway	0.85
G9A	regulates	protein	0.85
AKT1	regulates	protein	0.85
Epigallocatechin gallate	targets	compound	0.85
Cinobufagin	activates	compound	0.85
AKT1	inhibits	protein	0.85
EHMT2	inhibits	gene	0.85
YAP1	binds	protein	0.82
h-ae1b2beb	targets	hypothesis	0.80
G9a	regulates	enzyme	0.80
DAPK1	regulates	gene	0.80
AKT1	phosphorylates	gene	0.80
Cinobufagin	upregulates	compound	0.80
USP1	interacts_with	gene	0.80
SOD2	activates	gene	0.70
PI3K	regulates	gene	0.70
PTEN	phosphorylates	gene	0.70
PTEN	activates	gene	0.70
APOPTOSIS	regulates	gene	0.70
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.70
APOPTOSIS	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
METFORMIN	activates	drug	0.70
STROKE	activates	disease	0.70
MELATONIN	activates	drug	0.70
HEPATOCYTES	treats	cell_type	0.65
MELATONIN	interacts_with	drug	0.65
MAPK	interacts_with	gene	0.65
BAX	associated_with	gene	0.60
EHMT2	associated_with	gene	0.60
JUN	inhibits	gene	0.60
PPARGC1A	therapeutic_target	gene	0.60
SIRT3	therapeutic_target	gene	0.60
PRKAA1	therapeutic_target	gene	0.60
CREBBP	therapeutic_target	gene	0.60
PPARA	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
NOS3	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
GLP1R	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Transcriptional Autophagy-Lysosome Coupling	0.665	neurodegeneration	Autophagy-lysosome pathway convergence a

Mentioning Analyses (1)

Scientific analyses that reference this entity

Autophagy-lysosome pathway convergence across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.665

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Hepatocyte FoxO1 Deficiency Protects From Liver Fibrosis via Reducing Inflammati [PMID:37678798]	Pan Q, Gao M, Kim D, Ai W, Yang W, Jiang	Cell Mol Gastroenterol Hepatol	2024	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
Cinobufagin induces FOXO1-regulated apoptosis, proliferation, migration, and inv [PMID:35176466]	Zhang L, Liang B, Xu H, Gong Y, Hu W, Ji	J Ethnopharmacol	2022	1
Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK [PMID:31693892]	Wang Y, An H, Liu T, Qin C, Sesaki H, Gu	Cell Rep	2019	1
AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking Sy [PMID:30057310]	Song X, Zhu S, Chen P, Hou W, Wen Q, Liu	Curr Biol	2018	1
Obestatin controls the ubiquitin-proteasome and autophagy-lysosome systems in gl [PMID:28675664]	Cid-Díaz T, Santos-Zas I, González-Sánch	J Cachexia Sarcopenia Muscle	2017	1
PTEN loss drives B7H3 upregulation via the mTORC2/FOXO/c-Myc axis to promote tum [PMID:41920736]	Wang Z, Jin N, Li X, Ma X, Feng Y, Yin K	Cell reports	2026	0
Mammalian lipophagy: process and function. [PMID:41681129]	Zhao R, Dai E, Kang R, Liu J, Klionsky D	Autophagy	2026	0
TAZ alleviates ischemic stroke injury by activating Foxo1: Usp1-mediated deubiqu [PMID:41921828]	["Xin Y", "Sun Y", "Pan E", "Li M", "Che	Free radical biology & medicin	2026	0
Combining network pharmacology and multi-omics reveals the role of Shengdihuang- [PMID:41655545]	Cao X, Shang Y, Qu M, Kang Q, Xu Y et al	Phytomedicine	2026	0
A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling an [PMID:41718717]	Golec DP, Gazzinelli-Guimaraes PH, Chaus	J Exp Med	2026	0
Comparative transcriptomics of adherent and suspension chicken fibroblast cell l [PMID:41763754]	Contreras EJ, Nagarajan A, Bromberg BH,	Food Res Int	2026	0
FOXO1 transcription factor modulates airway epithelial responses to viral infect [PMID:41931532]	Daniel NM, Mann-Nüttel R, Shrestha Palik	PLoS One	2026	0
Clinical and immunological significance of FOXO1 as a biomarker of improved resp [PMID:41935603]	Du L, Wang J, Wang Y, Wang H, Xu X et al	Eur J Pharmacol	2026	0
Metformin attenuates TBHP-induced oxidative injury in human lens epithelial cell [PMID:41945556]	Yan Z, Chi W, Yan Z, Wang H	PLoS One	2026	0
Ponatinib inhibits LCK and PI3K signaling and promotes CD8(+) T stem cell memory [PMID:41946709]	Okuhiro Y, Ito S, Watanabe K, Yan Y, Kum	Nat Commun	2026	0
Loss of FoxO in skeletal muscle leads to disrupted muscle metabolism and exacerb [PMID:41950099]	Oyabu M, Sakaue M, Kubo A, Yoshioka K, K	Proc Natl Acad Sci U S A	2026	0
The deubiquitinase activity of CYLD is required for B cell differentiation. [PMID:41951576]	Pseftogas A, Bordini J, Gavriilidis G, F	Cell Death Dis	2026	0
Effects of Vitamin A Restriction on Carcass Characteristics, Antioxidant Capacit [PMID:41856090]	Zhang X, Zhang C, Song J, Bai J, Hao B,	Animal bioscience	2026	0
Transcriptomic identification of CREB1 and FOXO1 activation in neuregulin-1-medi [PMID:41907189]	Bennett KR, Surles-Zeigler MC, Augello C	Frontiers in molecular neurosc	2026	0

FOXO1

Understanding Entity Pages

Summary

Wiki Pages (21)

FOXO1 Gene

Autophagy Mechanisms

rapamycin-tauopathy

FOXO1 Protein

Transcriptional Regulation in Neurodegeneration

autophagy-lysosomal-alzheimers

FOXO4 — Forkhead Box O4

Autophagy-Lysosomal Pathway in Parkinson's Disease

autophagy-lysosome-dysfunction

Section 103: Sirtuin Pathway and NAD+-Dependent Deacetylases in CBS/PSP

GLP-1 Signaling Pathway in Neurodegeneration

AKT2 Gene

ABCD1 — ATP Binding Cassette Subfamily D Member 1

PDK4 (3-Phosphoinositide-Dependent Protein Kinase-4)

tfeb-activators-neurodegeneration

Autophagy Types in Neurodegeneration

autophagy-lysosomal-ad

autophagy

Autophagy-Impaired Neurons

pi3k-akt-signaling