gene

AKT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AKT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1615Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

AKT1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, therapeutic target, activates. Associated with ALS, Aging, Als. Connected to 765 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	AKT1
Full Name	AKT Serine/Threonine Kinase 1
Chromosome	14q32.33
Protein Type	Kinase
Function	is a serine/threonine protein kinase that serves as a central hub in the PI3K/AKT/mTOR signaling pathway, one of the most critical survival and growth signaling cascades in neurons.
Molecular Weight	~56 kDa
Amino Acids	480 aa
Exons	14 coding exons
Pathways	Akt, Apoptosis, Autophagy, Immune Response, Mapk
UniProt ID	P31749
NCBI Gene ID	207
Ensembl ID	ENSG00000142208
OMIM	164730
GeneCards	AKT1
Human Protein Atlas	AKT1
Associated Diseases	ALS, Aging, Alzheimer, Alzheimer's Disease, Ataxia
Known Drugs/Compounds	COUMESTROL, Coumestrol, Atbc, DMP, Andrographis paniculata, quercetin
Interactions	SQSTM1, RPS6KB1, GRB2, RHEB, STING1, EIF2A
KG Connections	1615 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    AKT1(["AKT1"])
    Cancer["Cancer"]
    Als["Als"]
    CANCER(["CANCER"])
    AKT(["AKT"])
    TP53(["TP53"])
    Pi3K_Akt["Pi3K/Akt"]
    GENES(["GENES"])
    TNF(["TNF"])
    IL6(["IL6"])
    PI3K(["PI3K"])
    Aerobic_Glycolysis("Aerobic Glycolysis")
    Lysosomal_Synapse_Formation("Lysosomal Synapse Formation")
    PIK3CA(["PIK3CA"])
    SLC2A1(["SLC2A1"])
    HK2["HK2"]

    AKT1 -->|"therapeutic target"| Cancer
    AKT1 -->|"therapeutic target"| Als
    AKT1 -->|"therapeutic target"| CANCER
    AKT1 -->|"therapeutic target"| AKT
    AKT1 -->|"therapeutic target"| TP53
    AKT1 -->|"therapeutic target"| Pi3K_Akt
    AKT1 -->|"therapeutic target"| GENES
    TNF -->|"therapeutic target"| AKT1
    AKT1 -->|"therapeutic target"| IL6
    AKT1 -->|"therapeutic target"| PI3K
    AKT1 -->|"associated with"| Aerobic_Glycolysis
    AKT1 -->|"modulates"| Lysosomal_Synapse_Formation
    PIK3CA -->|"activates"| AKT1
    AKT1 -->|"phosphorylates"| SLC2A1
    AKT1 -->|"phosphorylates"| HK2

    style AKT1 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (1141)

Target	Relation	Type	Str
AKT	therapeutic_target	gene	1.00
TP53	therapeutic_target	gene	1.00
Cancer	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
CANCER	therapeutic_target	gene	1.00
Pi3K/Akt	therapeutic_target	pathway	1.00
GENES	therapeutic_target	gene	1.00
IL6	therapeutic_target	gene	1.00
PI3K	therapeutic_target	gene	1.00
Aerobic Glycolysis	associated_with	process	0.95
Lysosomal Synapse Formation	modulates	process	0.95
autophagy	activates	process	0.92
PI3K	downstream_of	gene	0.92
SLC2A1	phosphorylates	gene	0.90
breast cancer	risk_factor_for	disease	0.90
TNF	targets	gene	0.90
GSK3B	inhibits	gene	0.90
aerobic glycolysis	promotes	process	0.90
protein synthesis	upregulates	process	0.90
Breast Cancer	involved_in	disease	0.90
Colorectal Cancer	associated_with	disease	0.90
JUN	therapeutic_target	gene	0.90
PI3K	inhibits	gene	0.90
EGFR	therapeutic_target	gene	0.90
CASP3	therapeutic_target	gene	0.90
VEGFA	therapeutic_target	gene	0.90
STAT3	therapeutic_target	gene	0.90
Mapk	therapeutic_target	pathway	0.90
Apoptosis	therapeutic_target	pathway	0.90
IL-6	therapeutic_target	gene	0.90
Pi3K/Akt/Mtor Pathway	involved_in	pathway	0.88
Osteoclast Differentiation	regulates	process	0.85
TNF Signaling Pathway	involved_in	pathway	0.85
Lysosomal Synapses	modulates	process	0.85
FOXO1	regulates	protein	0.85
HIF1A	regulates	protein	0.85
GSK3B	phosphorylates	protein	0.85
solar dermatitis	therapeutic_target	disease	0.85
age-related illness	therapeutic_target	disease	0.85
Bladder Cancer Metabolism	regulates	phenotype	0.85
niche formation	activates	process	0.85
FOXO1	inhibits	gene	0.85
Insomnia	therapeutic_target	disease	0.85
Fibrosis	therapeutic_target	disease	0.85
Cancer	activates	disease	0.85
Als	activates	disease	0.85
Inflammation	therapeutic_target	disease	0.85
Carcinoma	activates	disease	0.85
Tumor	therapeutic_target	disease	0.85
Cancer	inhibits	disease	0.85

Incoming (474)

Source	Relation	Type	Str
TNF	therapeutic_target	gene	1.00
PIK3CA	activates	gene	0.95
TBEV prM	interacts_with	protein	0.95
DMP	binds	compound	0.90
Berberine	binds_to	drug	0.90
Piperine	binds_to	drug	0.90
prM	interacts_with	protein	0.90
PDK1	phosphorylates	gene	0.90
SBP	downregulates	drug	0.90
PET-MPs	binds_to	drug	0.88
Coumestrol	binds	compound	0.85
Atbc	binds	compound	0.85
DEP	binds	compound	0.85
Ipatasertib	inhibits	drug	0.85
GPR39	activates	receptor	0.85
RLN	phosphorylates	protein	0.85
BDNF	interacts_with	gene	0.85
Pinghe Sleep Aromatherapy Product	targets	drug	0.85
Hyperthyroidism	upregulates	disease	0.85
Kudzu Root	regulates	drug	0.80
Cholix	phosphorylates	entity	0.80
Andrographis paniculata	modulates	drug	0.80
Transcranial near-infrared light	activates	compound	0.80
APOPTOSIS	inhibits	gene	0.80
Gap26	upregulates	compound	0.75
AKT	therapeutic_target	gene	0.70
PI3K	therapeutic_target	gene	0.70
PI3K	inhibits	gene	0.70
AKT	inhibits	gene	0.70
TNF	interacts_with	gene	0.70
RPS6	activates	gene	0.70
BAX	inhibits	gene	0.70
APOPTOSIS	activates	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
COUMESTROL	interacts_with	drug	0.64
OPTN	interacts_with	gene	0.60
CASP3	regulates	gene	0.60
IL1B	therapeutic_target	gene	0.60
IL6	therapeutic_target	gene	0.60
MAPK14	therapeutic_target	gene	0.60
GABARAP	interacts_with	gene	0.60
P38	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
JUN	therapeutic_target	gene	0.60
MMP9	therapeutic_target	gene	0.60
EGF	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
RAGE	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
CASP3	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

AKT1

Understanding Entity Pages

Summary

Wiki Pages (21)

AKT1 Gene

NTF4 Protein

omega-3-fatty-acids-neurodegeneration

Insulin Signaling in Parkinson's Disease

Apoptosis in Neurodegeneration

GSK3B Gene - Glycogen Synthase Kinase 3 Beta

TNF Signaling Pathway in Neurodegeneration

AKT2 Gene

mTOR Signaling in Neurodegeneration

PDPK1 Gene

GDNF Family Neurotrophic Factor Signaling Pathway in Neurodegeneration

NTF5 — Neurotrophin 5

TREM2 in ALS

GAB2 — GRB2 Associated Binding Protein 2

pi3k-akt-signaling

PIK3CG Gene

DJ-1-PTEN-P53 Network

ARRB2 — Arrestin Beta 2

Akt Signaling Pathway in Neurodegeneration