PJA1

Understanding Entity Pages

This page aggregates everything SciDEX knows about PJA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

PJA1 Gene — Praja1 RING Finger E3 Ubiquitin Ligase

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graph TD
    PJA1["<b>PJA1</b>"]
    Carcinoma{"Carcinoma"}
    PJA1 -->|"inhibits"| Carcinoma
    GSDME["GSDME"]
    PJA1 -->|"inhibits"| GSDME
    DRP1["DRP1"]
    PJA1 -->|"activates"| DRP1
    PYROPTOSIS["PYROPTOSIS"]
    PJA1 -->|"inhibits"| PYROPTOSIS
    UBIQUITIN["UBIQUITIN"]
    PJA1 -->|"activates"| UBIQUITIN
    Immune_Response(["Immune Response"])
    PJA1 -->|"activates"| Immune_Response
    Ubiquitin_Proteasome(["Ubiquitin-Proteasome"])
    PJA1 -->|"inhibits"| Ubiquitin_Proteasome
    Proteasome(["Proteasome"])
    PJA1 -->|"inhibits"| Proteasome
    Pyroptosis(["Pyroptosis"])
    PJA1 -->|"inhibits"| Pyroptosis
    neurodegeneration["neurodegeneration"]
    PJA1 -->|"implicated in"| neurodegeneration
    style PJA1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0