pathway

Ubiquitin-Proteasome

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Ubiquitin-Proteasome: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1428Connections

0Hypotheses

0Analyses

39Outgoing

50Incoming

Summary

Ubiquitin-Proteasome is a biological pathway involved in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with ALS, Aging, Als. Connected to 394 entities in the SciDEX knowledge graph.

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🔀 Pathway Info

Name	Ubiquitin-Proteasome
Key Genes/Proteins	UBIQUITIN, NEURODEGENERATION, CANCER, AUTOPHAGY, PARKINSON'S DISEASE
Related Diseases	Als, Neurodegeneration, Cancer, Parkinson

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Ubiquitin_Proteasome["Ubiquitin-Proteasome"] -->|"interacts"| Unfolded_Protein_Response["Unfolded Protein Response"]
    Ubiquitin_Proteasome["Ubiquitin-Proteasome"] -->|"interacts"| Mtor["Mtor"]
    OCLN["OCLN"] -->|"activates"| Ubiquitin_Proteasome["Ubiquitin-Proteasome"]
    BECN1["BECN1"] -->|"activates"| Ubiquitin_Proteasome["Ubiquitin-Proteasome"]
    CLDN5["CLDN5"] -->|"activates"| Ubiquitin_Proteasome["Ubiquitin-Proteasome"]
    CAV1["CAV1"] -->|"activates"| Ubiquitin_Proteasome["Ubiquitin-Proteasome"]
    style Ubiquitin_Proteasome fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (50)

Target	Relation	Type	Str
Unfolded Protein Response	interacts_with	pathway	0.55
Mtor	interacts_with	pathway	0.55
Cerebrovascular	activates	pathway	0.50
Endothelial Cell	activates	cell_type	0.50
disease	activates	disease	0.50
TJP1	activates	concept	0.50
ENDOTHELIAL	activates	concept	0.50
FRONTOTEMPORAL	activates	concept	0.50
RAPAMYCIN	activates	concept	0.50
IPSC	activates	concept	0.50
Proteins	activates	protein	0.50
disease	associated_with	disease	0.50
Proteostasis	associated_with	process	0.50
Proteins	interacts_with	protein	0.50
ENDOPLASMIC RETICULUM	interacts_with	concept	0.50
Reactive Oxygen Species	activates	process	0.50
ALZHEIMER'S	associated_with	concept	0.50
Chaperone	regulates	pathway	0.50
FBXW7	regulates	concept	0.50
CHAPERONE-MEDIATED AUTOPHAGY	regulates	concept	0.50
FBXW7	activates	concept	0.50
disease	regulates	disease	0.50
ALZHEIMER'S	regulates	concept	0.50
PARKINSON'S	regulates	concept	0.50
Protein Folding	regulates	pathway	0.50
Proteins	protects_against	protein	0.50
Stem Cell	activates	cell_type	0.50
Neuron	activates	cell_type	0.50
Endothelial	activates	cell_type	0.50
Stem Cell	regulates	cell_type	0.50
Neuron	degrades	cell_type	0.50
T Cell	causes	cell_type	0.50
Dopaminergic	activates	cell_type	0.50
T Cell	associated_with	cell_type	0.50
Neuron	stabilizes	cell_type	0.50
T Cell	activates	cell_type	0.50
Microglia	activates	cell_type	0.50
Neuron	associated_with	cell_type	0.50
Astrocyte	associated_with	cell_type	0.50

Incoming (1378)

Source	Relation	Type	Str
Als	activates	disease	1.00
Neurodegeneration	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Als	regulates	disease	1.00
UBIQUITIN	regulates	gene	1.00
NEURODEGENERATION	therapeutic_target	gene	1.00
UBIQUITIN	associated_with	gene	1.00
UBIQUITIN	activates	gene	1.00
UBIQUITIN	therapeutic_target	gene	1.00
CANCER	therapeutic_target	gene	1.00
Cancer	therapeutic_target	disease	1.00
Parkinson	therapeutic_target	disease	1.00
AUTOPHAGY	regulates	gene	1.00
PARKINSON'S DISEASE	therapeutic_target	gene	1.00
AUTOPHAGY	activates	gene	1.00
Tumor	therapeutic_target	disease	1.00
Neurodegeneration	activates	disease	0.90
UBIQUITIN	inhibits	gene	0.90
AUTOPHAGY	associated_with	gene	0.90
NEURODEGENERATION	activates	gene	0.90
UBIQUITIN	implicated_in	gene	0.90
NEURODEGENERATION	associated_with	gene	0.90
Neurodegeneration	associated_with	disease	0.90
PARKINSON	therapeutic_target	gene	0.90
GENES	activates	gene	0.80
Carcinoma	activates	disease	0.80
Tumor	activates	disease	0.80
P62	activates	gene	0.80
Aging	therapeutic_target	disease	0.80
LYSOSOME	regulates	gene	0.80
LYSOSOME	activates	gene	0.80
NEURODEGENERATION	regulates	gene	0.80
Neurodegeneration	regulates	disease	0.80
ALZHEIMER	associated_with	gene	0.80
Alzheimer	associated_with	disease	0.80
BECN1	activates	gene	0.70
LC3	activates	gene	0.70
MTOR	activates	gene	0.70
AKT	activates	gene	0.70
ATG	activates	gene	0.70
Dementia	activates	disease	0.70
Cancer	activates	disease	0.70
Aging	activates	disease	0.70
SQSTM1	activates	gene	0.70
PARKIN	therapeutic_target	gene	0.70
AKT	regulates	gene	0.70
OVERVIEW	therapeutic_target	gene	0.70
PI3K	regulates	gene	0.70
AGING	therapeutic_target	gene	0.70
ALPHA-SYNUCLEIN	therapeutic_target	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Ubiquitin-Proteasome

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Alzheimer's Disease Mechanism Index

Neuroresilience Mechanisms and Evidence

CBS/PSP Treatment Rankings

HNRNPA2B1 Protein

Autophagy Mechanisms

ftd-tdp-pathology

Mitophagy Pathway in Neurodegeneration

Lithium for PSP/CBS — Phase 2 Trial

LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

Pre-symptomatic Conversion Windows in ALS Genetic Risk Carriers

Paraventricular Hypothalamic Nucleus (PVN) Neurons

LRRK2 Pathway in Parkinson's Disease

Machado-Joseph Disease (Spinocerebellar Ataxia Type 3)

TDP-43 Proteinopathy

KARS1