pathway

Proteasome

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Proteasome: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

986Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Proteasome is a biological pathway involved in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with ALS, Aging, Als. Connected to 711 entities in the SciDEX knowledge graph.

View on Wiki →

🔀 Pathway Info

Name	Proteasome
Key Genes/Proteins	AUTOPHAGY, UBIQUITIN, PARKINSON'S DISEASE, NEURODEGENERATION, CANCER
Related Diseases	Neurodegeneration, Als
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Proteasome["Proteasome"] -->|"interacts"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    Proteasome["Proteasome"] -->|"interacts"| Ubiquitin_Proteasome["Ubiquitin-Proteasome"]
    Proteasome["Proteasome"] -->|"interacts"| Autophagy["Autophagy"]
    Proteasome["Proteasome"] -->|"interacts"| Unfolded_Protein_Response["Unfolded Protein Response"]
    Proteasome["Proteasome"] -->|"interacts"| Mtor["Mtor"]
    Proteasome["Proteasome"] -->|"interacts"| Apoptosis["Apoptosis"]
    OCLN["OCLN"] -->|"activates"| Proteasome["Proteasome"]
    BECN1["BECN1"] -->|"activates"| Proteasome["Proteasome"]
    CLDN5["CLDN5"] -->|"activates"| Proteasome["Proteasome"]
    CAV1["CAV1"] -->|"activates"| Proteasome["Proteasome"]
    style Proteasome fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (86)

Target	Relation	Type	Str
TAU	degrades	protein	0.85
Dementia	activates	disease	0.60
Als	activates	disease	0.60
Stroke	activates	disease	0.60
Als	inhibits	disease	0.60
Ischemia	inhibits	disease	0.60
Aging	degrades	disease	0.60
Ischemia	associated_with	disease	0.60
Als	interacts_with	disease	0.60
Aging	activates	disease	0.60
Cancer	activates	disease	0.60
Ferroptosis	degrades	disease	0.60
Ferroptosis	causes	disease	0.60
Neurodegeneration	causes	disease	0.60
Aging	inhibits	disease	0.60
Alzheimer	inhibits	disease	0.60
Cancer	therapeutic_target	disease	0.60
Neurodegeneration	therapeutic_target	disease	0.60
Als	expressed_in	disease	0.60
Alzheimer	regulates	disease	0.60
Als	therapeutic_target	disease	0.60
Parkinson	therapeutic_target	disease	0.60
Alzheimer	contributes_to	disease	0.60
Diabetes	regulates	disease	0.60
Atherosclerosis	regulates	disease	0.60
Parkinson	activates	disease	0.60
Aging	expressed_in	disease	0.60
Cancer	expressed_in	disease	0.60
Huntington	transports	disease	0.60
Parkinson	transports	disease	0.60
Alzheimer	transports	disease	0.60
Parkinson	associated_with	disease	0.60
Neurodegeneration	associated_with	disease	0.60
Prion Disease	regulates	disease	0.60
Parkinson	regulates	disease	0.60
Aging	interacts_with	disease	0.60
Amyotrophic Lateral Sclerosis	degrades	disease	0.60
Parkinson	degrades	disease	0.60
Neurodegeneration	degrades	disease	0.60
Alzheimer	degrades	disease	0.60
Fibrosis	therapeutic_target	disease	0.60
Als	contributes_to	disease	0.60
Blood-Brain Barrier	interacts_with	pathway	0.55
Ubiquitin-Proteasome	interacts_with	pathway	0.55
Autophagy	interacts_with	pathway	0.55
Unfolded Protein Response	interacts_with	pathway	0.55
Mtor	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Mitophagy	interacts_with	pathway	0.55
Ferroptosis	interacts_with	pathway	0.55

Incoming (900)

Source	Relation	Type	Str
Als	activates	disease	1.00
Neurodegeneration	activates	disease	1.00
Als	inhibits	disease	1.00
Neurodegeneration	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Parkinson	therapeutic_target	disease	1.00
Als	regulates	disease	1.00
AUTOPHAGY	regulates	gene	1.00
UBIQUITIN	regulates	gene	1.00
AUTOPHAGY	activates	gene	1.00
PARKINSON'S DISEASE	therapeutic_target	gene	1.00
NEURODEGENERATION	therapeutic_target	gene	1.00
UBIQUITIN	associated_with	gene	1.00
UBIQUITIN	inhibits	gene	1.00
UBIQUITIN	activates	gene	1.00
CANCER	therapeutic_target	gene	1.00
UBIQUITIN	therapeutic_target	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
NEURODEGENERATION	associated_with	gene	1.00
NEURODEGENERATION	activates	gene	1.00
Tumor	therapeutic_target	disease	1.00
Cancer	therapeutic_target	disease	1.00
UBIQUITIN	implicated_in	gene	1.00
PARKINSON	therapeutic_target	gene	1.00
GENES	activates	gene	1.00
P62	activates	gene	1.00
Aging	therapeutic_target	disease	1.00
AUTOPHAGY	therapeutic_target	gene	1.00
P53	therapeutic_target	gene	1.00
LYSOSOME	activates	gene	1.00
Neurodegeneration	associated_with	disease	1.00
Als	associated_with	disease	0.95
Aging	activates	disease	0.90
SQSTM1	activates	gene	0.90
APOPTOSIS	therapeutic_target	gene	0.90
NEURODEGENERATION	regulates	gene	0.90
CANCER	inhibits	gene	0.90
NEURODEGENERATION	causes	gene	0.90
Neurodegeneration	causes	disease	0.90
Cancer	regulates	disease	0.85
NEURON	expressed_in	cell_type	0.85
MTOR	activates	gene	0.80
ATG	activates	gene	0.80
Cancer	activates	disease	0.80
Carcinoma	activates	disease	0.80
Tumor	activates	disease	0.80
OVERVIEW	therapeutic_target	gene	0.80
AKT	therapeutic_target	gene	0.80
NF-ΚB	inhibits	gene	0.80
MTOR	therapeutic_target	gene	0.80

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Early Proteasome Restoration Therapy	0.496	neurodegeneration	Gene expression changes in aging mouse b

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (2)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Unveiling the Genomic Landscape of Yan Goose (Anser cygnoides): Insights into Po [PMID:41594384]	Qi S, Ai Z, Cai Y, Zhang Y, Zhao W et al	Animals (Basel)	2026	0
NAD+ restores proteostasis through splicing-dependent autophagy. [PMID:41313318]	Ai R, Fang EF	Autophagy	2026	0

Proteasome

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Alpha-Synuclein Pathology

Alzheimer's Disease Mechanism Index

nimodipine-als

Neuroresilience Mechanisms and Evidence

NPM1 Gene

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

CBS/PSP Treatment Rankings

NRF2 Oxidative Stress Pathway

nct07165106

GSK-3β in Neurodegeneration

HNRNPA2B1 Protein

Autophagy Mechanisms

oxidative-stress-comparison